SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vad'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.34A 1fkpA-2vadA:
undetectable		 1fkpA-2vadA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		4 / 5 PRO A 152
LEU A 157
THR A 147
ARG A 220
 None
CL  A1227 (-4.9A)
None
None
 0.92A 1i2wA-2vadA:
undetectable		 1i2wA-2vadA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.41A 1lw0A-2vadA:
undetectable		 1lw0A-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.40A 1lwcA-2vadA:
undetectable		 1lwcA-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 9 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.42A 1lwfA-2vadA:
undetectable		 1lwfA-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 9 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.37A 1vrtA-2vadA:
undetectable		 1vrtA-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		3 / 3 LEU A  54
PHE A  27
ARG A  95
 None
None
CRQ  A  66 ( 2.9A)
 0.88A 1xdkB-2vadA:
undetectable		 1xdkB-2vadA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.38A 2hndA-2vadA:
undetectable		 2hndA-2vadA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.36A 2hnyA-2vadA:
undetectable		 2hnyA-2vadA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.43A 3lp1A-2vadA:
undetectable		 3lp1A-2vadA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 10 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.42A 3qipA-2vadA:
undetectable		 3qipA-2vadA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
 None
CRQ  A  66 ( 3.8A)
None
None
None
 1.14A 4k38B-2vadA:
undetectable		 4k38B-2vadA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 PHE A  56
GLN A 213
LEU A  46
VAL A  48
ILE A  29
 None
CRQ  A  66 ( 3.8A)
None
None
None
 1.22A 4k39A-2vadA:
undetectable		 4k39A-2vadA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 PHE A 124
VAL A 122
HIS A 163
THR A 140
GLY A 142
 None
None
CRQ  A  66 ( 3.9A)
None
None
 1.17A 4olfA-2vadA:
undetectable		 4olfA-2vadA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 SER A  62
PHE A 177
MET A  97
HIS A 163
LEU A 199
 None
None
None
CRQ  A  66 ( 3.9A)
CRQ  A  66 ( 4.0A)
 1.36A 4xldA-2vadA:
undetectable		 4xldA-2vadA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		3 / 3 ARG A  17
LYS A  50
GLU A  28
 None
 0.70A 5d0yA-2vadA:
undetectable		 5d0yA-2vadA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		3 / 3 ILE A 119
MET A  83
ASP A 110
 None
CL  A1227 (-4.6A)
None
 0.81A 5h2uA-2vadA:
undetectable		 5h2uA-2vadA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 11 LEU A  61
VAL A  22
VAL A 105
GLY A 126
LEU A  54
 None
 1.39A 5hbmA-2vadA:
undetectable		 5hbmA-2vadA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		4 / 7 THR A 179
PHE A  91
GLN A 109
MET A  83
 None
None
CRQ  A  66 ( 4.0A)
CL  A1227 (-4.6A)
 1.43A 5u6mA-2vadA:
undetectable		 5u6mA-2vadA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		6 / 12 PHE A 124
VAL A 122
HIS A 163
PHE A  99
THR A 140
GLY A 142
 None
None
CRQ  A  66 ( 3.9A)
None
None
None
 1.24A 5xipA-2vadA:
undetectable		 5xipA-2vadA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 PHE A 124
VAL A 122
HIS A 163
PHE A  99
THR A 140
 None
None
CRQ  A  66 ( 3.9A)
None
None
 1.33A 5xipB-2vadA:
undetectable		 5xipB-2vadA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 VAL A 122
HIS A 163
PHE A  99
THR A 140
GLY A 142
 None
CRQ  A  66 ( 3.9A)
None
None
None
 1.21A 5xipC-2vadA:
undetectable		 5xipC-2vadA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 2vad RED FLUORESCENT
PROTEIN
(Discosoma
sp.) 		5 / 12 PHE A 124
VAL A 122
HIS A 163
THR A 140
GLY A 142
 None
None
CRQ  A  66 ( 3.9A)
None
None
 1.15A 5xiqD-2vadA:
undetectable		 5xiqD-2vadA:
19.60