SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vak'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.80A 1av2C-2vakA:
undetectable
1av2D-2vakA:
undetectable		 1av2C-2vakA:
5.53
1av2D-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		5 / 12 VAL A 289
ASN A 288
ALA A 282
LEU A 340
ALA A 344
 None
 1.04A 1fk6A-2vakA:
undetectable		 1fk6A-2vakA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.78A 1nrmA-2vakA:
undetectable		 1nrmA-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.78A 1nrmB-2vakA:
undetectable		 1nrmB-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.45A 1nt5A-2vakA:
undetectable		 1nt5A-2vakA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.45A 1nt5B-2vakA:
undetectable		 1nt5B-2vakA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.74A 1nt6A-2vakA:
undetectable		 1nt6A-2vakA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.74A 1nt6B-2vakA:
undetectable		 1nt6B-2vakA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.79A 1w5uC-2vakA:
undetectable
1w5uD-2vakA:
undetectable		 1w5uC-2vakA:
5.53
1w5uD-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 TRP A 105
ALA A  83
VAL A  85
 None
 0.79A 2izqA-2vakA:
undetectable
2izqB-2vakA:
undetectable		 2izqA-2vakA:
5.53
2izqB-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 7 PRO A 285
ILE A 376
GLY A 381
TRP A 409
 None
 0.99A 2y7kA-2vakA:
undetectable		 2y7kA-2vakA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 5 LEU A  28
ILE A 318
TRP A 132
TYR A  75
 None
 1.36A 2zlcA-2vakA:
undetectable		 2zlcA-2vakA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 4 GLY A 167
ASP A 408
GLY A 412
THR A 343
 None
 1.08A 3k4vC-2vakA:
undetectable		 3k4vC-2vakA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.81A 3l8lA-2vakA:
undetectable
3l8lB-2vakA:
undetectable		 3l8lA-2vakA:
5.53
3l8lB-2vakA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A  83
VAL A  85
TRP A 105
 None
 0.76A 3l8lC-2vakA:
undetectable
3l8lD-2vakA:
undetectable		 3l8lC-2vakA:
5.53
3l8lD-2vakA:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 8 ASN A 177
VAL A 270
ILE A 242
ALA A 184
 None
 0.99A 4eyzA-2vakA:
undetectable		 4eyzA-2vakA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 8 ASN A 177
VAL A 270
ILE A 242
ALA A 184
 None
 0.99A 4eyzB-2vakA:
undetectable		 4eyzB-2vakA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ASP A 257
ARG A 252
ASP A 286
 None
 0.80A 4fp9D-2vakA:
undetectable		 4fp9D-2vakA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ASP A 257
ARG A 252
ASP A 286
 None
 0.81A 4fzvA-2vakA:
undetectable		 4fzvA-2vakA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		4 / 6 ARG A 252
ALA A 369
ASP A 257
LEU A 341
 None
 1.02A 4ot2A-2vakA:
undetectable		 4ot2A-2vakA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2vak SIGMA A
(Avian
orthoreovirus) 		5 / 8 LEU A 421
VAL A 236
TYR A 232
TRP A 293
LEU A 338
 None
 1.37A 4pwdA-2vakA:
undetectable		 4pwdA-2vakA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 PRO A  86
LEU A  80
SER A  20
 None
 0.68A 5fsaB-2vakA:
undetectable		 5fsaB-2vakA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 LEU A 338
LEU A 229
ARG A 157
 None
 0.56A 5hnzB-2vakA:
undetectable		 5hnzB-2vakA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A 295
ASN A 298
LEU A 299
 None
 0.50A 5i1nC-2vakA:
undetectable		 5i1nC-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A 295
ASN A 298
LEU A 299
 None
 0.39A 5i1nB-2vakA:
undetectable		 5i1nB-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A 295
ASN A 298
LEU A 299
 None
 0.45A 5i1oA-2vakA:
undetectable		 5i1oA-2vakA:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ALA A 295
ASN A 298
LEU A 299
 None
 0.47A 5i1pD-2vakA:
undetectable		 5i1pD-2vakA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ASP A 257
ARG A 252
ASP A 286
 None
 0.61A 5zvgA-2vakA:
undetectable		 5zvgA-2vakA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 2vak SIGMA A
(Avian
orthoreovirus) 		3 / 3 ASP A 257
ARG A 252
ASP A 286
 None
 0.61A 5zvgB-2vakA:
undetectable		 5zvgB-2vakA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2vak SIGMA A
(Avian
orthoreovirus) 		5 / 9 SER A 226
THR A 174
ILE A 272
VAL A 270
ILE A 242
 None
 1.28A 6ef6A-2vakA:
undetectable		 6ef6A-2vakA:
20.52