SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2var'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 5 THR A 138
GLU A   9
THR A  87
LEU A  52
 None
 1.38A 1d4fC-2varA:
2.4		 1d4fC-2varA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 8 GLN A  13
ASP A 252
VAL A 288
GLY A 255
 None
None
None
ANP  A1315 (-3.0A)
 0.94A 1ekjA-2varA:
undetectable
1ekjB-2varA:
undetectable		 1ekjA-2varA:
22.56
1ekjB-2varA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 4 SER A 160
VAL A 149
PHE A  39
VAL A  43
 None
 1.40A 1o86A-2varA:
1.7		 1o86A-2varA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.45A 1odiB-2varA:
undetectable		 1odiB-2varA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.44A 1odiC-2varA:
undetectable		 1odiC-2varA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.43A 1odiD-2varA:
undetectable		 1odiD-2varA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.41A 1odiE-2varA:
undetectable		 1odiE-2varA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.40A 1odiF-2varA:
undetectable		 1odiF-2varA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 8 ARG A 108
GLY A   8
GLU A   9
SER A 134
ILE A  53
 KDF  A1314 ( 3.0A)
None
None
None
None
 1.28A 1pk7B-2varA:
undetectable		 1pk7B-2varA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 8 ALA A 145
ASN A 144
GLY A 113
GLY A 110
 None
 0.76A 1rukH-2varA:
undetectable
1rukL-2varA:
undetectable		 1rukH-2varA:
23.90
1rukL-2varA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 216
ILE A 189
THR A 199
 None
 0.86A 1rx3A-2varA:
undetectable		 1rx3A-2varA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BLA_A_CP6A302_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ILE A  12
ASN A  38
ILE A  41
TYR A  90
THR A  87
 None
KDF  A1314 ( 4.2A)
None
KDF  A1314 ( 4.0A)
None
 1.16A 2blaA-2varA:
undetectable		 2blaA-2varA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A  30
ASP A  59
ASN A  64
 None
 0.68A 2bm9A-2varA:
2.9		 2bm9A-2varA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 ALA A 284
THR A 263
PHE A 307
 None
 0.72A 2c6nB-2varA:
undetectable		 2c6nB-2varA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 8 GLY A  34
ASP A 258
THR A 135
ILE A 137
 KDG  A1313 ( 3.3A)
KDF  A1314 (-2.8A)
None
KDG  A1313 ( 3.3A)
 0.96A 2f9wA-2varA:
undetectable
2f9wB-2varA:
undetectable		 2f9wA-2varA:
22.19
2f9wB-2varA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 ALA A  54
GLY A  34
SER A  69
 None
KDG  A1313 ( 3.3A)
None
 0.46A 2ivuA-2varA:
undetectable		 2ivuA-2varA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 282
GLY A 228
PRO A 253
VAL A 288
LEU A 224
 ANP  A1315 ( 3.9A)
AMP  A1316 ( 3.4A)
None
None
None
 1.41A 3elzB-2varA:
undetectable		 3elzB-2varA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EQM_A_ASDA601_1
(CYTOCHROME P450 19A1)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 180
ILE A 165
ASP A 198
THR A 194
LEU A 203
 None
 1.33A 3eqmA-2varA:
undetectable		 3eqmA-2varA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 8 PRO A  10
ILE A  65
SER A  69
ILE A  74
 None
 1.06A 3sfeB-2varA:
undetectable
3sfeC-2varA:
undetectable		 3sfeB-2varA:
21.04
3sfeC-2varA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		6 / 12 GLY A  34
SER A  35
ASN A  38
GLU A  36
GLY A 255
ASP A 258
 KDG  A1313 ( 3.3A)
KDG  A1313 ( 3.8A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 (-3.0A)
KDF  A1314 (-2.8A)
 0.73A 3uboA-2varA:
35.9		 3uboA-2varA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.76A 3uboB-2varA:
36.8		 3uboB-2varA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A 252
VAL A 288
GLY A 255
ALA A 256
THR A 298
 None
None
ANP  A1315 (-3.0A)
AMP  A1316 ( 3.5A)
None
 1.20A 3ucjB-2varA:
undetectable		 3ucjB-2varA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  11
ILE A  79
GLY A  57
ILE A  65
ALA A 112
 KDG  A1313 ( 4.7A)
None
None
None
None
 0.97A 3uj7A-2varA:
undetectable		 3uj7A-2varA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  11
ILE A  79
GLY A  57
ILE A  65
ALA A 112
 KDG  A1313 ( 4.7A)
None
None
None
None
 1.00A 3uj7B-2varA:
3.7		 3uj7B-2varA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 175
THR A 179
ILE A 150
 None
 0.77A 4e0fB-2varA:
undetectable		 4e0fB-2varA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.69A 4e3aA-2varA:
36.8		 4e3aA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		6 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
GLY A 255
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
ANP  A1315 (-3.0A)
KDF  A1314 (-2.8A)
 0.65A 4e3aB-2varA:
36.8		 4e3aB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_B_ADNB500_1
(SUGAR KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
THR A 254
GLY A 255
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
ANP  A1315 ( 4.6A)
ANP  A1315 (-3.0A)
KDF  A1314 (-2.8A)
 0.84A 4e3aB-2varA:
36.8		 4e3aB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 8 GLY A  88
LEU A  11
ILE A  12
ILE A  65
 None
KDG  A1313 ( 4.7A)
None
None
 0.73A 4em2A-2varA:
undetectable		 4em2A-2varA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 8 TYR A 276
PHE A 264
VAL A 265
SER A 277
ALA A 304
 None
 1.47A 4eyzA-2varA:
undetectable		 4eyzA-2varA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 8 TYR A 276
PHE A 264
VAL A 265
SER A 277
ALA A 304
 None
 1.46A 4eyzB-2varA:
undetectable		 4eyzB-2varA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 LYS A 216
ILE A 189
THR A 199
 None
 0.86A 4gh8A-2varA:
0.8		 4gh8A-2varA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.72A 4jksA-2varA:
37.0		 4jksA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKS_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4jksB-2varA:
36.9		 4jksB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_A_ADNA500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4jkuA-2varA:
36.9		 4jkuA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4jkuB-2varA:
36.9		 4jkuB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k8cA-2varA:
36.9		 4k8cA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_B_ADNB401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k8cB-2varA:
37.0		 4k8cB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.72A 4k8kA-2varA:
36.9		 4k8kA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8K_B_ADNB403_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k8kB-2varA:
36.9		 4k8kB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4k8pA-2varA:
36.9		 4k8pA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4k8pB-2varA:
36.9		 4k8pB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k8tA-2varA:
36.9		 4k8tA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k8tB-2varA:
36.9		 4k8tB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k93A-2varA:
36.9		 4k93A-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4k93B-2varA:
37.0		 4k93B-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k9cA-2varA:
36.9		 4k9cA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.68A 4k9cB-2varA:
36.9		 4k9cB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4k9iA-2varA:
36.9		 4k9iA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4k9iB-2varA:
36.9		 4k9iB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.74A 4kadA-2varA:
37.0		 4kadA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.72A 4kadB-2varA:
36.9		 4kadB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4kahA-2varA:
37.0		 4kahA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kahB-2varA:
37.0		 4kahB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4kalA-2varA:
36.9		 4kalA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAL_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kalB-2varA:
36.9		 4kalB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kanA-2varA:
36.9		 4kanA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kanB-2varA:
36.9		 4kanB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kbeA-2varA:
36.8		 4kbeA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4kbeB-2varA:
36.9		 4kbeB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4lbgA-2varA:
36.9		 4lbgA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4lbgB-2varA:
37.0		 4lbgB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.72A 4lbxA-2varA:
36.9		 4lbxA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4lbxB-2varA:
37.0		 4lbxB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4lc4A-2varA:
36.9		 4lc4A-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4lc4B-2varA:
36.9		 4lc4B-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.71A 4lcaA-2varA:
37.0		 4lcaA-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LCA_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLY A  34
ASN A  38
GLU A  36
THR A 254
ASP A 258
 KDG  A1313 ( 3.3A)
KDF  A1314 ( 4.2A)
None
ANP  A1315 ( 4.6A)
KDF  A1314 (-2.8A)
 0.70A 4lcaB-2varA:
36.9		 4lcaB-2varA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A  11
GLY A  34
LEU A  52
VAL A  56
ILE A  41
 KDG  A1313 ( 4.7A)
KDG  A1313 ( 3.3A)
None
None
None
 1.28A 4okbA-2varA:
undetectable		 4okbA-2varA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A   6
LEU A 131
GLY A 262
ALA A 284
ALA A  42
 None
 1.19A 4pclA-2varA:
4.7		 4pclA-2varA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 7 LEU A 218
THR A 163
THR A 199
LEU A 202
 None
 0.87A 4z91F-2varA:
undetectable
4z91G-2varA:
undetectable
4z91H-2varA:
undetectable
4z91I-2varA:
undetectable
4z91J-2varA:
undetectable		 4z91F-2varA:
19.47
4z91G-2varA:
19.47
4z91H-2varA:
19.47
4z91I-2varA:
19.47
4z91J-2varA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 7 ASP A 198
ILE A 165
GLY A 136
THR A 194
 None
 1.01A 4zxiA-2varA:
4.4		 4zxiA-2varA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 GLY A 293
ASP A 252
ALA A  33
TYR A  90
LEU A  37
 None
None
KDF  A1314 (-3.4A)
KDF  A1314 ( 4.0A)
None
 1.35A 5hw4B-2varA:
undetectable		 5hw4B-2varA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JL7_A_ASDA601_1
(AROMATASE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ILE A 180
ILE A 165
ASP A 198
THR A 194
LEU A 203
 None
 1.34A 5jl7A-2varA:
undetectable		 5jl7A-2varA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 5 THR A  87
THR A 138
HIS A 133
LEU A  52
 None
 1.28A 5utuH-2varA:
4.8		 5utuH-2varA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 301
HIS A 280
THR A 263
GLU A 302
LEU A 308
 None
 1.41A 6aphA-2varA:
5.2		 6aphA-2varA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ASN A  38
PHE A  39
VAL A 265
THR A 135
ILE A 137
 KDF  A1314 ( 4.2A)
None
None
None
KDG  A1313 ( 3.3A)
 1.30A 6hcoA-2varA:
undetectable
6hcoB-2varA:
undetectable		 6hcoA-2varA:
19.64
6hcoB-2varA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		4 / 7 GLY A 281
PHE A 264
HIS A 280
SER A 266
 None
 1.07A 6hu9S-2varA:
undetectable
6hu9q-2varA:
undetectable		 6hu9S-2varA:
15.18
6hu9q-2varA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2var FRUCTOKINASE
(Sulfolobus
solfataricus) 		3 / 3 ARG A 166
LEU A 104
PHE A  91
 KDG  A1313 (-3.3A)
None
None
 0.70A 6nknP-2varA:
undetectable		 6nknP-2varA:
21.10