SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vaw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_C_DVAC8_0
(ACTINOMYCIN D)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 111
THR A 109
PRO A  75
 None
GDP  A1317 (-4.0A)
None
 0.87A 1fjaC-2vawA:
undetectable		 1fjaC-2vawA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FJA_D_DVAD8_0
(ACTINOMYCIN D)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		3 / 3 THR A 111
THR A 109
PRO A  75
 None
GDP  A1317 (-4.0A)
None
 0.87A 1fjaD-2vawA:
undetectable		 1fjaD-2vawA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  78
ILE A 116
ALA A  43
VAL A  19
LEU A  59
 None
 1.11A 1jg2A-2vawA:
3.2		 1jg2A-2vawA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.79A 1usqF-2vawA:
undetectable		 1usqF-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.80A 2a1mB-2vawA:
undetectable		 2a1mB-2vawA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 224
MET A 218
SER A 160
MET A  98
THR A 310
 None
 1.44A 2aa5A-2vawA:
undetectable		 2aa5A-2vawA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.26A 2e7fB-2vawA:
2.7		 2e7fB-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 8 THR A 228
GLY A 196
ASP A 199
THR A 266
 None
 0.92A 2f9wA-2vawA:
2.9
2f9wB-2vawA:
2.8		 2f9wA-2vawA:
23.16
2f9wB-2vawA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 190
VAL A 217
MET A 218
ILE A 197
 None
 1.13A 2hyyC-2vawA:
undetectable		 2hyyC-2vawA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.81A 2jkjE-2vawA:
undetectable		 2jkjE-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 PRO A  63
GLY A  68
THR A 109
GLY A  70
 None
None
GDP  A1317 (-4.0A)
None
 0.84A 2jklE-2vawA:
undetectable		 2jklE-2vawA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.28A 2ogyA-2vawA:
2.7		 2ogyA-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.29A 2ogyB-2vawA:
2.9		 2ogyB-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 8 VAL A 312
GLY A 315
THR A 314
GLY A 257
ALA A 258
 None
 1.39A 3aruA-2vawA:
3.4		 3aruA-2vawA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 PRO A  75
GLY A 108
GLY A 107
LEU A  83
ILE A  89
 None
GDP  A1317 (-3.4A)
GDP  A1317 (-3.5A)
None
None
 0.87A 3douA-2vawA:
4.4		 3douA-2vawA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A  20
GLY A  22
THR A 102
ALA A 113
ALA A  49
 GDP  A1317 (-3.4A)
GDP  A1317 (-3.3A)
None
None
None
 1.08A 3g8bA-2vawA:
3.7		 3g8bA-2vawA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_1
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 10 VAL A  27
LEU A  50
GLY A  24
VAL A  19
GLY A  21
 None
None
None
None
GDP  A1317 (-3.1A)
 1.14A 3ls4H-2vawA:
undetectable		 3ls4H-2vawA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GDP  A1317 ( 4.0A)
GDP  A1317 (-2.4A)
GDP  A1317 (-3.1A)
GDP  A1317 ( 4.0A)
 1.06A 3onnA-2vawA:
6.3		 3onnA-2vawA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 ILE A 172
LEU A 169
LYS A 168
ASN A 247
 None
 1.11A 4g19A-2vawA:
undetectable		 4g19A-2vawA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 4 ILE A 172
LEU A 169
LYS A 168
ASN A 247
 None
 1.05A 4g19D-2vawA:
undetectable		 4g19D-2vawA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 161
ALA A 224
THR A 314
VAL A 312
 None
 0.92A 4ik7A-2vawA:
undetectable		 4ik7A-2vawA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 138
GLY A 104
MET A 105
PHE A 136
LEU A 169
 None
GDP  A1317 (-3.1A)
None
None
None
 1.26A 4kowA-2vawA:
undetectable		 4kowA-2vawA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  83
GLY A  20
GLY A 110
ALA A  82
GLY A  72
 None
GDP  A1317 (-3.4A)
GDP  A1317 (-3.2A)
None
None
 0.96A 4n09D-2vawA:
8.6		 4n09D-2vawA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ALA A  49
ILE A  53
ASN A  52
ASN A  28
GLY A  24
 None
 1.21A 4obwD-2vawA:
4.4		 4obwD-2vawA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 112
ALA A 113
GLY A 108
PRO A  75
 None
None
GDP  A1317 (-3.4A)
None
 0.96A 4u9uA-2vawA:
5.0		 4u9uA-2vawA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 5 GLY A 112
ALA A 113
GLY A 108
PRO A  75
 None
None
GDP  A1317 (-3.4A)
None
 0.98A 4u9uB-2vawA:
3.5		 4u9uB-2vawA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 7 ILE A  89
LEU A  83
ALA A 113
ILE A 117
 None
 0.74A 4y03A-2vawA:
undetectable		 4y03A-2vawA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 164
GLU A 149
ALA A 113
ALA A 114
GLY A 108
 None
None
None
None
GDP  A1317 (-3.4A)
 1.21A 5igpA-2vawA:
undetectable		 5igpA-2vawA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1317 (-3.4A)
None
None
None
None
None
 1.46A 5kb6A-2vawA:
8.1		 5kb6A-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		6 / 12 GLY A  20
ILE A  17
ALA A 113
GLY A 112
ALA A 114
ILE A 117
 GDP  A1317 (-3.4A)
None
None
None
None
None
 1.46A 5kb6B-2vawA:
7.4		 5kb6B-2vawA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 161
ILE A 126
THR A 128
MET A 124
 None
 1.33A 5ljeA-2vawA:
undetectable		 5ljeA-2vawA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 106
GLY A 104
VAL A  19
ALA A 147
ASP A 148
 GDP  A1317 ( 4.0A)
GDP  A1317 (-3.1A)
None
None
None
 1.21A 5x7fA-2vawA:
4.1		 5x7fA-2vawA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vaw CELL DIVISION
PROTEIN FTSZ
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 104
THR A 103
GLY A  23
LEU A 170
PHE A 136
 GDP  A1317 (-3.1A)
None
None
None
None
 1.16A 5ybbA-2vawA:
undetectable		 5ybbA-2vawA:
21.50