SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		6 / 12 ARG A 134
PRO A 159
VAL A  93
LEU A  83
ALA A  79
PHE A  68
 ARG  A 134 ( 0.6A)
PRO  A 159 ( 1.1A)
VAL  A  93 ( 0.6A)
LEU  A  83 ( 0.6A)
ALA  A  79 ( 0.0A)
PHE  A  68 ( 1.3A)
 1.44A 1gseB-2vbfA:
undetectable		 1gseB-2vbfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 LEU A 366
VAL A 506
MET A 509
LEU A 354
 LEU  A 366 ( 0.6A)
VAL  A 506 ( 0.6A)
MET  A 509 ( 0.0A)
LEU  A 354 ( 0.6A)
 0.98A 1hk3A-2vbfA:
undetectable		 1hk3A-2vbfA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 PHE A 381
GLY A 397
SER A 244
PHE A 395
 PHE  A 381 ( 1.3A)
GLY  A 397 ( 0.0A)
SER  A 244 ( 0.0A)
PHE  A 395 ( 1.3A)
 1.34A 1icuC-2vbfA:
undetectable
1icuD-2vbfA:
undetectable		 1icuC-2vbfA:
18.27
1icuD-2vbfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		3 / 3 PHE A 318
LEU A 303
MET A 300
 PHE  A 318 ( 1.3A)
LEU  A 303 ( 0.6A)
MET  A 300 ( 0.0A)
 0.77A 1mx1D-2vbfA:
undetectable		 1mx1D-2vbfA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A  12
LEU A 150
ARG A 148
THR A 135
ALA A 133
 LEU  A  12 ( 0.6A)
LEU  A 150 ( 0.5A)
ARG  A 148 ( 0.6A)
THR  A 135 ( 0.8A)
ALA  A 133 ( 0.0A)
 1.15A 1n5xA-2vbfA:
undetectable		 1n5xA-2vbfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A  12
LEU A 150
ARG A 148
THR A 135
ALA A 133
 LEU  A  12 ( 0.6A)
LEU  A 150 ( 0.5A)
ARG  A 148 ( 0.6A)
THR  A 135 ( 0.8A)
ALA  A 133 ( 0.0A)
 1.15A 1n5xB-2vbfA:
undetectable		 1n5xB-2vbfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ASP A 274
PRO A 235
LYS A 342
SER A 265
ALA A 273
 ASP  A 274 ( 0.6A)
PRO  A 235 ( 1.1A)
LYS  A 342 ( 0.0A)
SER  A 265 ( 0.0A)
ALA  A 273 ( 0.0A)
 1.27A 1nw5A-2vbfA:
undetectable		 1nw5A-2vbfA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.13A 1q23A-2vbfA:
undetectable		 1q23A-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ALA A 212
VAL A 246
ALA A 245
HIS A 214
 ALA  A 212 ( 0.0A)
VAL  A 246 ( 0.6A)
ALA  A 245 ( 0.0A)
HIS  A 214 ( 1.0A)
 1.20A 1q23F-2vbfA:
undetectable		 1q23F-2vbfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 150
LEU A 180
GLY A  16
ALA A  65
ALA A  60
 LEU  A 150 ( 0.5A)
LEU  A 180 ( 0.6A)
GLY  A  16 ( 0.0A)
ALA  A  65 ( 0.0A)
ALA  A  60 ( 0.0A)
 1.19A 2bm9D-2vbfA:
3.1		 2bm9D-2vbfA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 GLY A 289
GLY A 242
PHE A 381
PHE A 382
 GLY  A 289 ( 0.0A)
GLY  A 242 ( 0.0A)
PHE  A 381 ( 1.3A)
PHE  A 382 ( 1.3A)
 0.96A 2qwxA-2vbfA:
undetectable
2qwxB-2vbfA:
undetectable		 2qwxA-2vbfA:
16.35
2qwxB-2vbfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 8 GLU A 156
ARG A 148
ALA A 132
ALA A 133
 GLU  A 156 ( 0.6A)
ARG  A 148 ( 0.6A)
ALA  A 132 ( 0.0A)
ALA  A 133 ( 0.0A)
 1.03A 3ax9B-2vbfA:
undetectable		 3ax9B-2vbfA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 VAL A 160
ARG A  11
ILE A  17
THR A 135
 VAL  A 160 ( 0.6A)
ARG  A  11 ( 0.6A)
ILE  A  17 ( 0.7A)
THR  A 135 ( 0.8A)
 1.29A 3cl9A-2vbfA:
undetectable		 3cl9A-2vbfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 295
ALA A 273
ASP A 274
ILE A 236
ILE A 276
 LEU  A 295 ( 0.6A)
ALA  A 273 ( 0.0A)
ASP  A 274 ( 0.6A)
ILE  A 236 ( 0.6A)
ILE  A 276 ( 0.6A)
 1.07A 3d1zB-2vbfA:
undetectable		 3d1zB-2vbfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ILE A 427
SER A 431
LEU A 432
THR A 435
 ILE  A 427 ( 0.7A)
SER  A 431 (-0.0A)
LEU  A 432 ( 0.5A)
THR  A 435 ( 0.8A)
 0.86A 3deuB-2vbfA:
undetectable		 3deuB-2vbfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 9 ILE A 450
TYR A 520
ILE A 522
LYS A 497
GLU A 511
 ILE  A 450 ( 0.7A)
TYR  A 520 ( 1.3A)
ILE  A 522 ( 0.6A)
LYS  A 497 ( 0.0A)
GLU  A 511 ( 0.6A)
 1.04A 3f78A-2vbfA:
3.8		 3f78A-2vbfA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ILE A 333
LEU A 279
VAL A 324
VAL A 216
ILE A 236
 ILE  A 333 ( 0.6A)
LEU  A 279 ( 0.6A)
VAL  A 324 ( 0.6A)
VAL  A 216 ( 0.6A)
ILE  A 236 ( 0.6A)
 1.08A 3gwxB-2vbfA:
undetectable		 3gwxB-2vbfA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 154
GLY A 220
ARG A 394
LEU A  15
ILE A  17
 LEU  A 154 ( 0.6A)
GLY  A 220 ( 0.0A)
ARG  A 394 ( 0.6A)
LEU  A  15 ( 0.6A)
ILE  A  17 ( 0.7A)
 1.14A 3ijdB-2vbfA:
undetectable		 3ijdB-2vbfA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 ALA A 133
LEU A 150
ARG A  11
ILE A  96
LEU A  12
 ALA  A 133 ( 0.0A)
LEU  A 150 ( 0.5A)
ARG  A  11 ( 0.6A)
ILE  A  96 ( 0.6A)
LEU  A  12 ( 0.6A)
 1.11A 3k2hA-2vbfA:
undetectable		 3k2hA-2vbfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 295
ALA A 273
ASP A 274
ILE A 236
ILE A 276
 LEU  A 295 ( 0.6A)
ALA  A 273 ( 0.0A)
ASP  A 274 ( 0.6A)
ILE  A 236 ( 0.6A)
ILE  A 276 ( 0.6A)
 1.05A 3k4vC-2vbfA:
undetectable		 3k4vC-2vbfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 THR A 237
VAL A 210
ILE A 276
SER A 272
PRO A 208
 THR  A 237 ( 0.8A)
VAL  A 210 ( 0.6A)
ILE  A 276 ( 0.6A)
SER  A 272 ( 0.0A)
PRO  A 208 ( 1.1A)
 1.24A 3kpbA-2vbfA:
undetectable		 3kpbA-2vbfA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 ILE A 396
THR A  62
VAL A 374
ILE A 373
ASN A 370
 ILE  A 396 ( 0.7A)
THR  A  62 ( 0.8A)
VAL  A 374 ( 0.5A)
ILE  A 373 ( 0.7A)
ASN  A 370 ( 0.6A)
 1.25A 3kpcA-2vbfA:
undetectable		 3kpcA-2vbfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 TYR A   7
VAL A  93
VAL A 149
ILE A  96
 TYR  A   7 ( 1.3A)
VAL  A  93 ( 0.6A)
VAL  A 149 ( 0.6A)
ILE  A  96 ( 0.6A)
 1.31A 3ms9B-2vbfA:
undetectable		 3ms9B-2vbfA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 GLU A 156
ARG A 148
ALA A 132
ALA A 133
 GLU  A 156 ( 0.6A)
ARG  A 148 ( 0.6A)
ALA  A 132 ( 0.0A)
ALA  A 133 ( 0.0A)
 1.09A 3ns1C-2vbfA:
undetectable		 3ns1C-2vbfA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 10 LEU A 295
ALA A 273
ASP A 274
ILE A 236
ILE A 276
 LEU  A 295 ( 0.6A)
ALA  A 273 ( 0.0A)
ASP  A 274 ( 0.6A)
ILE  A 236 ( 0.6A)
ILE  A 276 ( 0.6A)
 1.05A 3nu6B-2vbfA:
undetectable		 3nu6B-2vbfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 ALA A 142
ILE A 146
LEU A 137
ALA A 171
 ALA  A 142 ( 0.0A)
ILE  A 146 ( 0.7A)
LEU  A 137 ( 0.6A)
ALA  A 171 ( 0.0A)
 0.78A 3r9sA-2vbfA:
undetectable		 3r9sA-2vbfA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 9 LEU A 359
LEU A 526
ILE A 498
GLU A 523
PHE A 505
 LEU  A 359 ( 0.5A)
LEU  A 526 ( 0.5A)
ILE  A 498 ( 0.7A)
GLU  A 523 ( 0.5A)
PHE  A 505 ( 1.3A)
 1.28A 3tmzA-2vbfA:
undetectable		 3tmzA-2vbfA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 526
GLY A 428
GLY A 405
LEU A 524
ASP A 429
 LEU  A 526 ( 0.5A)
GLY  A 428 (-0.0A)
GLY  A 405 ( 0.0A)
LEU  A 524 ( 0.6A)
ASP  A 429 ( 0.6A)
 1.04A 4blvA-2vbfA:
4.1		 4blvA-2vbfA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.19A 4eckB-2vbfA:
undetectable		 4eckB-2vbfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.24A 4eilA-2vbfA:
2.1		 4eilA-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.20A 4eilC-2vbfA:
undetectable		 4eilC-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4eilE-2vbfA:
undetectable		 4eilE-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		3 / 3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.82A 4fp9A-2vbfA:
undetectable		 4fp9A-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		3 / 3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.71A 4fp9C-2vbfA:
undetectable		 4fp9C-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		3 / 3 ASP A 319
ARG A 321
ASP A 306
 ASP  A 319 ( 0.6A)
ARG  A 321 ( 0.6A)
ASP  A 306 ( 0.6A)
 0.73A 4fp9F-2vbfA:
undetectable		 4fp9F-2vbfA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 HIS A 423
TYR A 406
GLY A  58
SER A 414
 HIS  A 423 ( 1.0A)
TYR  A 406 ( 1.3A)
GLY  A  58 ( 0.0A)
SER  A 414 ( 0.0A)
 1.30A 4fu8A-2vbfA:
undetectable		 4fu8A-2vbfA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.29A 4kyaA-2vbfA:
2.2		 4kyaA-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.33A 4kyaB-2vbfA:
2.2		 4kyaB-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 10 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaC-2vbfA:
undetectable		 4kyaC-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaD-2vbfA:
undetectable		 4kyaD-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.27A 4kyaE-2vbfA:
undetectable		 4kyaE-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 11 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.26A 4kyaG-2vbfA:
2.0		 4kyaG-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 VAL A 160
SER A 151
LEU A  15
VAL A  94
THR A 135
 VAL  A 160 ( 0.6A)
SER  A 151 ( 0.0A)
LEU  A  15 ( 0.6A)
VAL  A  94 ( 0.6A)
THR  A 135 ( 0.8A)
 1.30A 4kyaH-2vbfA:
undetectable		 4kyaH-2vbfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 261
GLY A 259
THR A 237
ILE A 211
VAL A 209
 LEU  A 261 ( 0.6A)
GLY  A 259 ( 0.0A)
THR  A 237 ( 0.8A)
ILE  A 211 ( 0.7A)
VAL  A 209 ( 0.6A)
 1.14A 4okwA-2vbfA:
undetectable		 4okwA-2vbfA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 9 ILE A 453
PHE A 408
LEU A 432
LEU A 439
PHE A 487
 ILE  A 453 ( 0.4A)
PHE  A 408 ( 1.3A)
LEU  A 432 ( 0.5A)
LEU  A 439 ( 0.5A)
PHE  A 487 ( 1.3A)
 1.06A 4qopA-2vbfA:
undetectable		 4qopA-2vbfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 9 ILE A 453
PHE A 408
LEU A 432
LEU A 439
PHE A 487
 ILE  A 453 ( 0.4A)
PHE  A 408 ( 1.3A)
LEU  A 432 ( 0.5A)
LEU  A 439 ( 0.5A)
PHE  A 487 ( 1.3A)
 1.08A 4qopB-2vbfA:
undetectable		 4qopB-2vbfA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ASN A 141
VAL A   4
THR A 135
ILE A 162
 ASN  A 141 ( 0.6A)
VAL  A   4 ( 0.6A)
THR  A 135 ( 0.8A)
ILE  A 162 ( 0.7A)
 1.27A 4retA-2vbfA:
3.2		 4retA-2vbfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 4 ASN A 141
VAL A   4
THR A 135
ILE A 162
 ASN  A 141 ( 0.6A)
VAL  A   4 ( 0.6A)
THR  A 135 ( 0.8A)
ILE  A 162 ( 0.7A)
 1.27A 4retC-2vbfA:
2.4		 4retC-2vbfA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 LEU A 250
SER A 252
ILE A 236
VAL A 210
 LEU  A 250 ( 0.6A)
SER  A 252 ( 0.0A)
ILE  A 236 ( 0.6A)
VAL  A 210 ( 0.6A)
 1.15A 4tvtA-2vbfA:
undetectable		 4tvtA-2vbfA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		3 / 3 LYS A 419
ILE A 416
ILE A  44
 LYS  A 419 ( 0.0A)
ILE  A 416 ( 0.7A)
ILE  A  44 ( 0.7A)
 0.73A 4y0qA-2vbfA:
undetectable		 4y0qA-2vbfA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 6 LEU A 359
TRP A 360
SER A 380
PHE A 381
 LEU  A 359 ( 0.5A)
TRP  A 360 ( 0.5A)
SER  A 380 ( 0.0A)
PHE  A 381 ( 1.3A)
 1.29A 5b8iA-2vbfA:
undetectable		 5b8iA-2vbfA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 GLU A  89
ALA A  60
GLY A  58
TYR A  54
 GLU  A  89 ( 0.5A)
ALA  A  60 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A  54 ( 1.3A)
 1.02A 5uxdA-2vbfA:
undetectable		 5uxdA-2vbfA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 7 GLN A 415
GLY A 413
ILE A 396
ASP A  57
 GLN  A 415 ( 0.6A)
GLY  A 413 ( 0.0A)
ILE  A 396 ( 0.7A)
ASP  A  57 ( 0.5A)
 1.16A 5vlmC-2vbfA:
undetectable		 5vlmC-2vbfA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A  69
GLY A  22
PHE A  21
ASN A  46
ASP A  40
 LEU  A  69 ( 0.5A)
GLY  A  22 ( 0.0A)
PHE  A  21 ( 1.3A)
ASN  A  46 ( 0.6A)
ASP  A  40 ( 0.6A)
 1.13A 5x66A-2vbfA:
undetectable
5x66B-2vbfA:
undetectable		 5x66A-2vbfA:
19.89
5x66B-2vbfA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		4 / 5 ALA A 411
SER A 414
GLY A  58
TYR A 406
 ALA  A 411 ( 0.0A)
SER  A 414 ( 0.0A)
GLY  A  58 ( 0.0A)
TYR  A 406 ( 1.3A)
 1.27A 5yodB-2vbfA:
undetectable		 5yodB-2vbfA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 LEU A 295
ALA A 273
ASP A 274
ILE A 236
ILE A 276
 LEU  A 295 ( 0.6A)
ALA  A 273 ( 0.0A)
ASP  A 274 ( 0.6A)
ILE  A 236 ( 0.6A)
ILE  A 276 ( 0.6A)
 1.03A 6difA-2vbfA:
undetectable		 6difA-2vbfA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE
(Lactococcus
lactis) 		5 / 12 THR A 386
ILE A 256
TYR A 257
LEU A 534
MET A 538
 THR  A 386 ( 0.8A)
ILE  A 256 ( 0.7A)
TYR  A 257 ( 1.3A)
LEU  A 534 ( 0.6A)
MET  A 538 ( 0.0A)
 1.30A 6ie8A-2vbfA:
undetectable		 6ie8A-2vbfA:
14.61