SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vbi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLY A 294
ALA A 548
SER A 549
GLY A 263
LEU A 540
 None
 1.11A 1nbhB-2vbiA:
3.4		 1nbhB-2vbiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 TRP A 298
PRO A 299
LEU A 215
GLY A 217
 None
 1.40A 1ya4C-2vbiA:
undetectable		 1ya4C-2vbiA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.12A 2cmlA-2vbiA:
undetectable		 2cmlA-2vbiA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 LEU A  13
LEU A   9
ILE A  16
ARG A  12
 None
 0.91A 2rlfC-2vbiA:
undetectable
2rlfD-2vbiA:
undetectable		 2rlfC-2vbiA:
7.24
2rlfD-2vbiA:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 SER A 218
PRO A 285
ALA A 244
VAL A 274
TYR A 261
 None
 1.11A 2zifB-2vbiA:
undetectable		 2zifB-2vbiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 GLU A  58
ASN A 421
VAL A 381
ARG A  62
 None
 1.38A 3amuA-2vbiA:
0.0		 3amuA-2vbiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		3 / 3 MET A 406
VAL A 402
GLU A 383
 None
 0.90A 3c6gA-2vbiA:
undetectable		 3c6gA-2vbiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_B_TMQB612_1
(DHFR-TS)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 ALA A 100
ILE A 170
ILE A 148
PRO A 145
ILE A  97
 None
 1.21A 3clbB-2vbiA:
2.2		 3clbB-2vbiA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 7 GLY A 217
TYR A 261
VAL A 274
LEU A 306
 None
 0.92A 3elzA-2vbiA:
undetectable		 3elzA-2vbiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.08A 3sanA-2vbiA:
undetectable		 3sanA-2vbiA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.06A 3sanB-2vbiA:
undetectable		 3sanB-2vbiA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.13A 3ticA-2vbiA:
undetectable		 3ticA-2vbiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.13A 3ticB-2vbiA:
undetectable		 3ticB-2vbiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.14A 3ticC-2vbiA:
undetectable		 3ticC-2vbiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.14A 3ticD-2vbiA:
undetectable		 3ticD-2vbiA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 ARG A 258
LEU A 273
PRO A 212
VAL A 213
 None
 1.12A 3ufnA-2vbiA:
undetectable
3ufnB-2vbiA:
undetectable		 3ufnA-2vbiA:
10.54
3ufnB-2vbiA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 10 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 220
 None
 1.35A 3uudB-2vbiA:
undetectable		 3uudB-2vbiA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.00A 4cpnA-2vbiA:
undetectable		 4cpnA-2vbiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_A_ZMRA1471_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.07A 4cpzA-2vbiA:
undetectable		 4cpzA-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_B_ZMRB1471_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.03A 4cpzB-2vbiA:
undetectable		 4cpzB-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.02A 4cpzC-2vbiA:
undetectable		 4cpzC-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.09A 4cpzD-2vbiA:
undetectable		 4cpzD-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.04A 4cpzF-2vbiA:
undetectable		 4cpzF-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.11A 4cpzG-2vbiA:
undetectable		 4cpzG-2vbiA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 ASN A  29
GLN A 124
ALA A  77
SER A  74
TYR A 123
 None
 1.30A 4ejwA-2vbiA:
0.0		 4ejwA-2vbiA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLY A 499
ILE A 458
MET A 489
ILE A 457
ARG A 522
 None
 1.10A 4iv0B-2vbiA:
2.8		 4iv0B-2vbiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 MET A 433
LEU A 380
ARG A 393
SER A 438
 None
None
None
TPP  A2000 (-2.5A)
 1.43A 4kmmB-2vbiA:
2.1		 4kmmB-2vbiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 SER A 172
GLY A  26
ASP A  27
GLY A  99
 None
 1.04A 4koeA-2vbiA:
undetectable
4koeB-2vbiA:
undetectable
4koeC-2vbiA:
undetectable		 4koeA-2vbiA:
21.88
4koeB-2vbiA:
21.88
4koeC-2vbiA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 8 ALA A 146
ASP A 165
ILE A 138
ASP A 140
ILE A 170
 None
 1.44A 4kttB-2vbiA:
undetectable		 4kttB-2vbiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 8 ALA A 146
ASP A 165
ILE A 138
ASP A 140
ILE A 170
 None
 1.42A 4kttD-2vbiA:
undetectable		 4kttD-2vbiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLY A 499
ILE A 458
MET A 489
ILE A 457
ARG A 522
 None
 1.10A 4mwzA-2vbiA:
2.7		 4mwzA-2vbiA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		6 / 12 LEU A 331
LEU A 324
ALA A 307
LEU A 281
THR A 241
ALA A 225
 None
 1.26A 4o2bD-2vbiA:
undetectable		 4o2bD-2vbiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 GLU A  90
ALA A 418
GLU A  58
ASN A 421
ARG A 221
 None
 1.12A 4wa5A-2vbiA:
undetectable		 4wa5A-2vbiA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_1
(ESTROGEN RECEPTOR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 220
 None
 1.23A 4xi3D-2vbiA:
undetectable		 4xi3D-2vbiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 324
 None
 1.20A 4zn7A-2vbiA:
undetectable		 4zn7A-2vbiA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		6 / 12 GLY A 412
GLN A 444
SER A 417
VAL A 434
VAL A 432
VAL A 381
 None
 1.29A 5dpdA-2vbiA:
2.1		 5dpdA-2vbiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		6 / 12 GLY A 412
GLN A 444
SER A 417
VAL A 434
VAL A 432
VAL A 381
 None
 1.34A 5dpdB-2vbiA:
2.0		 5dpdB-2vbiA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 11 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 220
 None
 1.35A 5hyrB-2vbiA:
undetectable		 5hyrB-2vbiA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 LEU A 206
ALA A 335
LEU A 232
ILE A 305
ILE A 283
 None
 0.90A 5itzB-2vbiA:
undetectable		 5itzB-2vbiA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 PRO A 507
LYS A 508
ILE A 514
ALA A 515
LYS A 518
 None
 0.68A 5j2tC-2vbiA:
2.3		 5j2tC-2vbiA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		3 / 3 VAL A 293
SER A 291
TRP A 543
 None
 0.97A 5jwaA-2vbiA:
undetectable		 5jwaA-2vbiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 SER A  98
VAL A  71
GLY A  76
ALA A  77
 None
 0.93A 5k50A-2vbiA:
undetectable		 5k50A-2vbiA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUN_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 9 ALA A  69
ILE A  16
LEU A  13
ILE A 152
ALA A  57
 None
 0.88A 5nunA-2vbiA:
undetectable		 5nunA-2vbiA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 ASN A 390
THR A 537
ASN A 363
ILE A 461
 None
 1.19A 5uigA-2vbiA:
undetectable		 5uigA-2vbiA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 TRP A 295
THR A 292
ASN A 288
LEU A 280
 None
 1.50A 5vkqA-2vbiA:
0.0
5vkqB-2vbiA:
0.0		 5vkqA-2vbiA:
15.61
5vkqB-2vbiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 TRP A 295
THR A 292
ASN A 288
LEU A 280
 None
 1.49A 5vkqB-2vbiA:
0.0
5vkqC-2vbiA:
0.0		 5vkqB-2vbiA:
15.61
5vkqC-2vbiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 TRP A 295
THR A 292
ASN A 288
LEU A 280
 None
 1.48A 5vkqC-2vbiA:
0.0
5vkqD-2vbiA:
0.0		 5vkqC-2vbiA:
15.61
5vkqD-2vbiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 4 ASN A 288
LEU A 280
TRP A 295
THR A 292
 None
 1.47A 5vkqA-2vbiA:
0.7
5vkqD-2vbiA:
0.0		 5vkqA-2vbiA:
15.61
5vkqD-2vbiA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 10 ALA A 307
LEU A 281
LEU A 280
MET A 243
LEU A 220
 None
 1.34A 5wgqB-2vbiA:
undetectable		 5wgqB-2vbiA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		5 / 12 ILE A 152
ALA A 155
ILE A  97
ALA A 134
LEU A  18
 None
 1.15A 6a5zD-2vbiA:
undetectable		 6a5zD-2vbiA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 5 GLU A  58
ASN A 421
VAL A 381
ARG A  62
 None
 1.46A 6aggZ-2vbiA:
0.0		 6aggZ-2vbiA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 GLU A 365
LYS A 508
GLU A 358
ALA A 359
 None
 0.83A 6an0A-2vbiA:
undetectable		 6an0A-2vbiA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 SER A 209
SER A 277
ALA A 340
SER A 341
 None
 0.92A 6bocA-2vbiA:
undetectable
6bocB-2vbiA:
undetectable
6bocC-2vbiA:
undetectable
6bocD-2vbiA:
undetectable		 6bocA-2vbiA:
3.85
6bocB-2vbiA:
3.85
6bocC-2vbiA:
3.85
6bocD-2vbiA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 2vbi PYRUVATE
DECARBOXYLASE
(Acetobacter
pasteurianus) 		4 / 6 SER A 209
SER A 277
ALA A 340
SER A 341
 None
 0.93A 6bocA-2vbiA:
undetectable
6bocB-2vbiA:
undetectable
6bocC-2vbiA:
undetectable
6bocD-2vbiA:
undetectable		 6bocA-2vbiA:
3.85
6bocB-2vbiA:
3.85
6bocC-2vbiA:
3.85
6bocD-2vbiA:
3.85