SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vbk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 8 GLY A 405
LEU A 398
LEU A 396
PHE A 415
 None
 0.87A 2vctA-2vbkA:
undetectable		 2vctA-2vbkA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 8 GLY A 405
LEU A 398
LEU A 396
PHE A 415
 None
 0.86A 2vctB-2vbkA:
undetectable		 2vctB-2vbkA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 LEU A 398
ALA A 423
ILE A 435
SER A 467
ASP A 397
 None
 1.19A 3axtA-2vbkA:
undetectable		 3axtA-2vbkA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 10 ILE A 368
PHE A 322
ILE A 351
SER A 332
LEU A 320
 None
 1.25A 3o1cA-2vbkA:
undetectable		 3o1cA-2vbkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 9 ILE A 183
ILE A 179
VAL A 218
ILE A 197
ILE A 220
 None
 1.27A 3p4wB-2vbkA:
undetectable		 3p4wB-2vbkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_B_SVRB516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 7 GLY A 486
ALA A 490
TRP A 489
ALA A 469
 None
 0.80A 3ur0B-2vbkA:
undetectable		 3ur0B-2vbkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 6 GLY A 302
ILE A 271
GLN A 301
VAL A 363
 None
 1.08A 4d39B-2vbkA:
undetectable		 4d39B-2vbkA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 5 HIS A 321
TYR A 356
GLN A 301
GLY A 324
 None
 1.31A 4fu8A-2vbkA:
undetectable		 4fu8A-2vbkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 6 GLY A 302
ILE A 271
GLN A 301
VAL A 363
 None
 1.06A 4kcnA-2vbkA:
undetectable		 4kcnA-2vbkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 11 VAL A 281
GLY A 302
CYH A 326
LEU A 242
SER A 238
 None
 1.42A 4or0A-2vbkA:
undetectable		 4or0A-2vbkA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ALA A 182
LEU A 212
SER A 227
ILE A 256
LEU A 253
 None
 1.07A 4qi9A-2vbkA:
undetectable		 4qi9A-2vbkA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ALA A 182
LEU A 212
SER A 227
ILE A 256
LEU A 253
 None
 1.07A 4qi9B-2vbkA:
undetectable		 4qi9B-2vbkA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		3 / 3 ASN A 410
PHE A 437
TYR A 436
 None
 0.87A 4u15A-2vbkA:
undetectable		 4u15A-2vbkA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		3 / 3 SER A 365
GLU A 409
GLU A 345
 None
 0.87A 4ymgB-2vbkA:
undetectable		 4ymgB-2vbkA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ILE A 454
GLY A 434
VAL A 407
PHE A 417
VAL A 479
 None
 1.20A 5n0rA-2vbkA:
undetectable		 5n0rA-2vbkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ILE A 454
GLY A 434
VAL A 407
PHE A 417
VAL A 479
 None
 1.19A 5n0wA-2vbkA:
undetectable		 5n0wA-2vbkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 ILE A 454
GLY A 434
VAL A 407
PHE A 417
VAL A 479
 None
 1.19A 5n0xB-2vbkA:
undetectable		 5n0xB-2vbkA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 PHE A 502
ALA A 469
GLY A 434
GLY A 481
VAL A 449
 None
 0.89A 5w4zA-2vbkA:
undetectable		 5w4zA-2vbkA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 PHE A 502
ALA A 469
GLY A 434
GLY A 481
VAL A 449
 None
 0.89A 5w4zB-2vbkA:
undetectable		 5w4zB-2vbkA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA606_1
(SERUM ALBUMIN)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		5 / 12 VAL A 281
GLY A 302
CYH A 326
LEU A 242
SER A 238
 None
 1.40A 6ci6A-2vbkA:
undetectable		 6ci6A-2vbkA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 6 GLY A 518
ASN A 540
SER A 516
ARG A 538
 GOL  A1301 ( 3.7A)
None
None
None
 1.18A 6dwdA-2vbkA:
undetectable
6dwdC-2vbkA:
undetectable		 6dwdA-2vbkA:
20.07
6dwdC-2vbkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2vbk TAILSPIKE-PROTEIN
(Shigella
virus
Sf6) 		4 / 7 ILE A 183
LEU A 195
ARG A 241
LEU A 229
 None
 0.96A 6nmfA-2vbkA:
undetectable
6nmfJ-2vbkA:
undetectable		 6nmfA-2vbkA:
22.01
6nmfJ-2vbkA:
10.69