SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vc2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 7 ARG A 400
ASP A 373
ASP A 365
TYR A 371
 None
CA  A2006 (-2.4A)
CA  A2006 (-3.4A)
None
 1.29A 1cebA-2vc2A:
undetectable		 1cebA-2vc2A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 6 TRP A 262
GLY A 233
ASN A 227
PRO A 258
 None
 1.44A 1dedA-2vc2A:
undetectable		 1dedA-2vc2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 11 GLY A 184
LEU A 195
GLY A 187
TYR A 274
GLU A 268
 None
 1.40A 1iolA-2vc2A:
undetectable		 1iolA-2vc2A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 7 PHE A 204
SER A 144
PHE A 131
LEU A  68
 None
 1.08A 1qcaA-2vc2A:
undetectable		 1qcaA-2vc2A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 TYR A 274
SER A 218
GLY A 184
TYR A 253
TYR A 143
 None
 1.37A 1xvaA-2vc2A:
undetectable		 1xvaA-2vc2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 LEU A   3
LEU A 366
GLY A 423
ALA A 361
ALA A 359
 None
 1.08A 2bm9F-2vc2A:
undetectable		 2bm9F-2vc2A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 VAL A 239
SER A  96
VAL A  98
SER A 172
 None
 1.25A 2j9cA-2vc2A:
undetectable
2j9cB-2vc2A:
undetectable
2j9cC-2vc2A:
undetectable		 2j9cA-2vc2A:
11.21
2j9cB-2vc2A:
11.21
2j9cC-2vc2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 LEU A 306
ILE A 360
SER A 292
GLY A 290
 None
 0.89A 2otfA-2vc2A:
undetectable		 2otfA-2vc2A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 VAL A 241
TYR A 253
VAL A 182
SER A 172
 None
 1.29A 2x45A-2vc2A:
undetectable		 2x45A-2vc2A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1161_1
(ALLERGEN ARG R 1)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 4 VAL A 241
TYR A 253
VAL A 182
SER A 172
 None
 1.24A 2x45B-2vc2A:
0.0		 2x45B-2vc2A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1161_1
(ALLERGEN ARG R 1)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 VAL A 241
TYR A 253
VAL A 182
SER A 172
 None
 1.25A 2x45C-2vc2A:
undetectable		 2x45C-2vc2A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 GLN A 451
GLN A   7
ASP A 434
ASP A 429
 None
None
CA  A2007 (-2.4A)
None
 1.40A 3bwcB-2vc2A:
2.5		 3bwcB-2vc2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 VAL A  53
GLY A  38
GLY A  20
ALA A 106
ILE A 104
 None
 0.93A 3fuuA-2vc2A:
undetectable		 3fuuA-2vc2A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 8 LEU A 421
ALA A 377
SER A 358
SER A 292
 None
 1.11A 3rodA-2vc2A:
undetectable		 3rodA-2vc2A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 6 GLY A 381
TYR A 353
ALA A 378
GLU A 324
 None
 0.76A 4ae1A-2vc2A:
undetectable		 4ae1A-2vc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 5 THR A 176
GLY A 179
VAL A 200
PRO A 199
 None
 1.17A 4grkA-2vc2A:
undetectable		 4grkA-2vc2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 8 ALA A 122
SER A 152
TYR A 166
TYR A 155
 None
 1.22A 4ijiF-2vc2A:
undetectable		 4ijiF-2vc2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		3 / 3 VAL A 445
PHE A  25
ARG A 422
 None
 0.90A 4xr4B-2vc2A:
undetectable		 4xr4B-2vc2A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 11 LEU A 399
LEU A 347
LEU A 407
LEU A 366
LEU A   3
 None
 0.99A 4zowA-2vc2A:
undetectable		 4zowA-2vc2A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 8 SER A 238
GLY A 256
ALA A 286
GLY A 265
 None
 0.80A 5albL-2vc2A:
undetectable		 5albL-2vc2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 7 SER A 287
ALA A 286
PRO A 258
LEU A 264
 None
 1.02A 5dzkD-2vc2A:
undetectable
5dzkR-2vc2A:
undetectable		 5dzkD-2vc2A:
19.17
5dzkR-2vc2A:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_3
(PROTEASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		3 / 3 ASP A 367
VAL A 391
LEU A   3
 CA  A2006 (-2.9A)
None
None
 0.68A 5e5jB-2vc2A:
undetectable		 5e5jB-2vc2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 4 ALA A 361
PRO A 379
LEU A 312
HIS A 291
 None
 1.20A 5eskA-2vc2A:
undetectable		 5eskA-2vc2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 ALA A  39
GLY A  52
GLY A  92
GLY A  13
SER A  17
 None
 1.12A 5gwxA-2vc2A:
undetectable		 5gwxA-2vc2A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 LEU A 306
SER A 344
PHE A 289
GLY A 256
ILE A 360
 None
 1.08A 5m24A-2vc2A:
undetectable		 5m24A-2vc2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 GLY A 438
PRO A  40
GLY A  52
PHE A  70
ILE A 104
 None
 1.14A 5tuiB-2vc2A:
undetectable		 5tuiB-2vc2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 8 GLY A  44
LEU A  43
SER A  17
ALA A  39
 None
 0.96A 5xu8A-2vc2A:
undetectable		 5xu8A-2vc2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		5 / 12 ALA A 377
SER A 358
LEU A 435
GLY A  20
LEU A  23
 None
 1.00A 6b0cD-2vc2A:
undetectable		 6b0cD-2vc2A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens) 		4 / 6 PHE A  70
VAL A 103
LEU A  55
LEU A  68
 None
 1.04A 6e43D-2vc2A:
undetectable		 6e43D-2vc2A:
21.62