SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 8 SER A  35
LEU A 256
LEU A 243
LEU A 239
 None
 1.00A 2bfpA-2vc6A:
2.8		 2bfpA-2vc6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 8 SER A  35
LEU A 256
LEU A 243
LEU A 239
 None
 0.99A 2bfpB-2vc6A:
2.9		 2bfpB-2vc6A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 8 SER A  80
SER A  78
ASN A  79
LYS A  52
 None
 1.16A 2cmlD-2vc6A:
undetectable		 2cmlD-2vc6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 6 ASP A 265
PHE A  13
THR A  49
GLU A  46
 None
 1.37A 2dttB-2vc6A:
undetectable
2dttC-2vc6A:
undetectable		 2dttB-2vc6A:
15.36
2dttC-2vc6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FK8_A_SAMA302_1
(METHOXY MYCOLIC ACID
SYNTHASE 4)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		3 / 3 SER A 138
THR A 146
GLN A 111
 None
 0.78A 2fk8A-2vc6A:
undetectable		 2fk8A-2vc6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 5 LEU A 192
LEU A 236
CYH A 202
THR A 185
 None
 1.43A 2oaxD-2vc6A:
undetectable		 2oaxD-2vc6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  42
CYH A  41
ILE A  18
LEU A  23
VAL A  27
 MCL  A 161 ( 3.4A)
None
None
None
None
 0.98A 3adxB-2vc6A:
undetectable		 3adxB-2vc6A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		6 / 12 LEU A 256
CYH A  41
ILE A  18
LEU A  23
LEU A  26
VAL A  27
 None
 1.27A 3adxB-2vc6A:
undetectable		 3adxB-2vc6A:
26.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 4 LEU A   9
PRO A  40
LEU A  38
ARG A  69
 None
 1.45A 3hcoA-2vc6A:
undetectable		 3hcoA-2vc6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A  42
VAL A  39
GLY A 186
THR A 185
 MCL  A 161 ( 3.4A)
None
MCL  A 161 ( 3.7A)
None
 0.88A 3ib2A-2vc6A:
undetectable		 3ib2A-2vc6A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  72
ILE A  73
ILE A   6
VAL A  39
PRO A  40
 None
 0.87A 3kpdC-2vc6A:
undetectable		 3kpdC-2vc6A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		3 / 3 GLU A 173
GLU A 141
ASN A 133
 None
 0.85A 3lp9B-2vc6A:
undetectable
3lp9D-2vc6A:
undetectable		 3lp9B-2vc6A:
22.29
3lp9D-2vc6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A 163
ASP A 162
ILE A 114
THR A  43
 MCL  A 161 ( 4.6A)
None
None
MCL  A 161 ( 4.6A)
 0.84A 4eyrA-2vc6A:
undetectable		 4eyrA-2vc6A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		5 / 12 ILE A 290
ALA A 212
GLN A  30
THR A   7
LEU A 256
 None
 1.36A 4qzuA-2vc6A:
undetectable		 4qzuA-2vc6A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		5 / 11 GLY A  42
CYH A  41
ILE A  18
LEU A  23
LEU A  26
 MCL  A 161 ( 3.4A)
None
None
None
None
 1.01A 4xumB-2vc6A:
undetectable		 4xumB-2vc6A:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		4 / 7 VAL A 209
VAL A  10
GLY A 251
TYR A 254
 None
 0.91A 5x80C-2vc6A:
undetectable
5x80D-2vc6A:
undetectable		 5x80C-2vc6A:
19.80
5x80D-2vc6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		5 / 12 PHE A   2
LEU A 183
GLY A 199
VAL A  39
ILE A   6
 None
 1.46A 6bxnB-2vc6A:
undetectable		 6bxnB-2vc6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 2vc6 DIHYDRODIPICOLINATE
SYNTHASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A 100
ASP A 122
ILE A 150
 MCL  A 161 ( 4.7A)
None
None
 0.61A 6dh0B-2vc6A:
undetectable		 6dh0B-2vc6A:
13.21