SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 VAL A 594
TRP A 560
TRP A 548
 None
 1.30A 1c4dA-2vcaA:
undetectable
1c4dB-2vcaA:
undetectable		 1c4dA-2vcaA:
2.28
1c4dB-2vcaA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A 360
SER A 304
LEU A 789
MET A 788
LEU A 807
 None
 1.38A 1fm6D-2vcaA:
undetectable		 1fm6D-2vcaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 9 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.95A 1hpvA-2vcaA:
undetectable		 1hpvA-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ALA A  46
ASP A  47
VAL A  69
ILE A  50
ILE A  67
 None
 0.90A 1hsgB-2vcaA:
undetectable		 1hsgB-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 LEU A 612
ILE A 633
THR A 629
THR A 654
ILE A 651
 None
 1.42A 1i18A-2vcaA:
undetectable
1i18B-2vcaA:
undetectable		 1i18A-2vcaA:
7.66
1i18B-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 THR A 654
ILE A 651
LEU A 612
ILE A 633
THR A 629
 None
 1.41A 1i18A-2vcaA:
undetectable
1i18B-2vcaA:
undetectable		 1i18A-2vcaA:
7.66
1i18B-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 ARG A 205
ALA A 323
ALA A 250
PHE A 253
GLY A 252
 None
 1.20A 1mjqG-2vcaA:
undetectable
1mjqH-2vcaA:
undetectable		 1mjqG-2vcaA:
8.52
1mjqH-2vcaA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 LEU A 728
LEU A 762
ILE A 910
GLU A 698
 None
 0.94A 1n13I-2vcaA:
undetectable
1n13L-2vcaA:
undetectable		 1n13I-2vcaA:
5.53
1n13L-2vcaA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.84A 1n49B-2vcaA:
undetectable		 1n49B-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.83A 1n49C-2vcaA:
undetectable		 1n49C-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK2_A_ACAA91_1
(TISSUE-TYPE
PLASMINOGEN
ACTIVATOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 8 TYR A 476
ASP A 507
ASP A 509
LEU A 329
 None
 1.27A 1pk2A-2vcaA:
undetectable		 1pk2A-2vcaA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 ILE A 106
LEU A  71
LYS A 131
ILE A 150
ILE A  94
 None
 1.27A 1rb3A-2vcaA:
undetectable		 1rb3A-2vcaA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ALA A  46
ASP A  47
VAL A  69
ILE A  50
ILE A  67
 None
 0.82A 1sdtB-2vcaA:
undetectable		 1sdtB-2vcaA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 ALA A  46
ASP A  47
VAL A  69
ILE A  50
ILE A  67
 None
 0.82A 1sdvB-2vcaA:
undetectable		 1sdvB-2vcaA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ILE A 701
ASP A 720
PHE A 717
 None
 0.46A 1uwjB-2vcaA:
undetectable		 1uwjB-2vcaA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ILE A 333
ALA A 365
MET A 307
ILE A 603
MET A 394
 None
 1.32A 1y0xX-2vcaA:
undetectable		 1y0xX-2vcaA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 728
ASN A 731
LEU A 729
ALA A 730
GLN A 766
 None
 1.14A 2aa6A-2vcaA:
undetectable		 2aa6A-2vcaA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.81A 2avsA-2vcaA:
undetectable		 2avsA-2vcaA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.82A 2avvB-2vcaA:
undetectable		 2avvB-2vcaA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.83A 2avvD-2vcaA:
undetectable		 2avvD-2vcaA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ALA A 722
THR A 772
PHE A 704
 None
 0.75A 2c6nB-2vcaA:
0.1		 2c6nB-2vcaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 PHE A 475
ASN A 561
LEU A 613
GLY A 595
ILE A 559
 None
 1.28A 2e7fB-2vcaA:
8.4		 2e7fB-2vcaA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 PHE A 475
ASN A 561
LEU A 613
GLY A 595
ILE A 559
 None
 1.25A 2ogyA-2vcaA:
8.2		 2ogyA-2vcaA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 PHE A 475
ASN A 561
LEU A 613
GLY A 595
ILE A 559
 None
 1.26A 2ogyB-2vcaA:
4.9		 2ogyB-2vcaA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 6 LEU A 613
TRP A 558
MET A 593
LEU A 587
 None
 1.31A 2oz7A-2vcaA:
undetectable		 2oz7A-2vcaA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.84A 2q64A-2vcaA:
undetectable		 2q64A-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.86A 2qakA-2vcaA:
undetectable		 2qakA-2vcaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ALA A  46
ASP A  47
VAL A  69
ILE A  50
ILE A  67
 None
 0.87A 2r5pB-2vcaA:
undetectable		 2r5pB-2vcaA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ILE A 124
ALA A  96
ILE A  67
ILE A 147
LEU A  71
 None
 1.06A 2rlcA-2vcaA:
undetectable		 2rlcA-2vcaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 PHE A 309
ALA A 804
ASN A 780
ILE A 603
ASN A 604
 None
 1.14A 2rlcA-2vcaA:
undetectable		 2rlcA-2vcaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ALA A 730
THR A 654
ILE A 724
ASP A 723
PHE A 697
 None
 1.31A 2v95A-2vcaA:
undetectable		 2v95A-2vcaA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 8 TYR A 719
ARG A 636
GLY A 270
PRO A 267
 None
 1.06A 2ys6A-2vcaA:
undetectable		 2ys6A-2vcaA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 894
LEU A 765
ALA A 705
MET A 899
ALA A 898
 None
 1.29A 3b0wA-2vcaA:
undetectable		 3b0wA-2vcaA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 9 VAL A 152
ILE A 132
GLY A 130
ILE A  74
ILE A  29
 None
 1.12A 3ekqB-2vcaA:
undetectable		 3ekqB-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.86A 3el1B-2vcaA:
undetectable		 3el1B-2vcaA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 GLU A 356
GLU A 352
TRP A  66
 None
 1.03A 3hrdA-2vcaA:
undetectable
3hrdE-2vcaA:
undetectable
3hrdF-2vcaA:
undetectable		 3hrdA-2vcaA:
18.88
3hrdE-2vcaA:
18.88
3hrdF-2vcaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 ILE A 219
LYS A 242
GLY A 243
SER A 251
LEU A 196
 None
 1.30A 3ik6B-2vcaA:
undetectable
3ik6E-2vcaA:
undetectable		 3ik6B-2vcaA:
14.40
3ik6E-2vcaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 ILE A 219
LYS A 242
GLY A 243
SER A 251
LEU A 196
 None
 1.36A 3iluB-2vcaA:
undetectable
3iluE-2vcaA:
undetectable		 3iluB-2vcaA:
14.40
3iluE-2vcaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.85A 3k4vB-2vcaA:
undetectable		 3k4vB-2vcaA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 8 GLY A 252
PHE A 253
ILE A 216
PHE A 211
 None
 0.98A 3ko0O-2vcaA:
undetectable
3ko0Q-2vcaA:
undetectable		 3ko0O-2vcaA:
8.00
3ko0Q-2vcaA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 ASP A 854
PHE A 752
LEU A 760
SER A 756
PHE A 759
 None
 1.42A 3ko0Q-2vcaA:
undetectable
3ko0R-2vcaA:
0.0
3ko0S-2vcaA:
0.0
3ko0T-2vcaA:
undetectable		 3ko0Q-2vcaA:
8.00
3ko0R-2vcaA:
8.00
3ko0S-2vcaA:
8.00
3ko0T-2vcaA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.76A 3nduC-2vcaA:
undetectable		 3nduC-2vcaA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 TYR A 882
ASP A 870
ASP A 836
 None
 0.83A 3r24A-2vcaA:
undetectable		 3r24A-2vcaA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 5 SER A 429
ARG A 416
PRO A 415
VAL A 414
 None
None
GOL  A1914 ( 4.6A)
GOL  A1914 (-4.2A)
 1.16A 3sufC-2vcaA:
undetectable		 3sufC-2vcaA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.81A 3tl9B-2vcaA:
undetectable		 3tl9B-2vcaA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 TRP A 548
VAL A 544
TRP A 560
 None
 1.06A 3zq8C-2vcaA:
undetectable
3zq8D-2vcaA:
undetectable		 3zq8C-2vcaA:
2.28
3zq8D-2vcaA:
2.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ASN A 325
TRP A 321
ASP A 615
 None
 1.00A 4a7tA-2vcaA:
undetectable
4a7tF-2vcaA:
undetectable		 4a7tA-2vcaA:
10.18
4a7tF-2vcaA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ASN A 371
LEU A 807
PHE A 367
 None
 0.69A 4dajB-2vcaA:
undetectable		 4dajB-2vcaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 GLY A  72
GLY A  73
TYR A  75
ASN A 156
 None
 0.69A 4fgkB-2vcaA:
undetectable		 4fgkB-2vcaA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 728
ASN A 731
LEU A 729
ALA A 730
GLN A 766
 None
 1.20A 4fn9B-2vcaA:
undetectable		 4fn9B-2vcaA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_1
(HIV-1 PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		6 / 12 GLY A  73
ASP A  70
VAL A 152
ILE A 132
VAL A  27
ILE A  29
 None
 1.35A 4jecA-2vcaA:
undetectable		 4jecA-2vcaA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A602_1
(SERUM ALBUMIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 VAL A 739
MET A 740
ALA A 743
PHE A 752
 None
 0.92A 4lb2A-2vcaA:
undetectable		 4lb2A-2vcaA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.82A 4njvC-2vcaA:
undetectable		 4njvC-2vcaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 11 VAL A 152
ILE A 132
GLY A 130
ILE A  74
ILE A  29
 None
 0.91A 4njvC-2vcaA:
undetectable		 4njvC-2vcaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.90A 4njvD-2vcaA:
undetectable		 4njvD-2vcaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 VAL A 152
ILE A 132
GLY A 130
ILE A  74
ILE A  29
 None
 1.01A 4njvD-2vcaA:
undetectable		 4njvD-2vcaA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		6 / 12 LEU A 718
PHE A 717
GLY A 892
ALA A 705
ALA A 647
ILE A 644
 None
 1.41A 4nkxB-2vcaA:
undetectable		 4nkxB-2vcaA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ARG A 768
ALA A 895
GLY A 892
LEU A 891
TYR A 708
 None
 1.38A 4oadA-2vcaA:
undetectable		 4oadA-2vcaA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA701_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 5 ASP A  63
MET A 372
TRP A 811
TYR A 363
 None
None
NAG  A1912 ( 4.8A)
None
 1.29A 4p7nA-2vcaA:
11.5		 4p7nA-2vcaA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 GLU A  31
TYR A  75
GLY A  72
GLY A  32
 None
 0.89A 4rdxA-2vcaA:
undetectable		 4rdxA-2vcaA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 PHE A 318
LEU A 319
THR A 302
VAL A 330
 None
 0.87A 4wnvD-2vcaA:
undetectable		 4wnvD-2vcaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ASN A 244
SER A 248
ARG A 295
 None
 0.69A 5b2qA-2vcaA:
2.3		 5b2qA-2vcaA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 6 TRP A 618
GLY A 326
SER A 251
VAL A 247
 None
 0.94A 5ewuA-2vcaA:
undetectable		 5ewuA-2vcaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 6 TRP A 618
GLY A 326
SER A 251
VAL A 247
 None
 0.97A 5ewuB-2vcaA:
undetectable		 5ewuB-2vcaA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 9 LEU A 894
LEU A 765
ALA A 705
MET A 899
ALA A 898
 None
 1.19A 5g44A-2vcaA:
undetectable		 5g44A-2vcaA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 LEU A 563
VAL A 544
PHE A 541
TYR A 825
GLY A 686
 None
None
None
NAG  A1912 (-3.8A)
None
 1.28A 5i8fA-2vcaA:
undetectable		 5i8fA-2vcaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ASP A 715
ASN A 266
PHE A 721
 None
 0.82A 5jglB-2vcaA:
undetectable		 5jglB-2vcaA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 ALA A 602
PHE A 704
ILE A 644
THR A 654
MET A 572
 None
 1.21A 5jlcA-2vcaA:
undetectable		 5jlcA-2vcaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 PHE A 300
ILE A 333
TYR A 368
GLY A 477
THR A 487
 None
None
None
None
GOL  A1913 ( 4.4A)
 1.25A 5jlcA-2vcaA:
undetectable		 5jlcA-2vcaA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 6 GLY A 376
SER A 359
TYR A 363
ASN A 803
 None
 0.75A 5k4pA-2vcaA:
undetectable		 5k4pA-2vcaA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 9 VAL A 152
ILE A 132
GLY A 130
ILE A  74
ILE A  29
 None
 1.03A 5kqxB-2vcaA:
undetectable		 5kqxB-2vcaA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TTF_C_SAMC1505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A 377
SER A 813
ASN A 803
TRP A 811
PHE A 436
 None
None
None
NAG  A1912 ( 4.8A)
None
 0.79A 5ttfC-2vcaA:
undetectable		 5ttfC-2vcaA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 TRP A 321
MET A 324
ASN A 254
 None
 1.42A 5uc1B-2vcaA:
undetectable		 5uc1B-2vcaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 TRP A 321
MET A 324
ASN A 254
 None
 1.46A 5uc1A-2vcaA:
undetectable		 5uc1A-2vcaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		4 / 7 GLN A 370
GLY A 412
ILE A 428
TYR A 445
 None
 1.09A 5vlmC-2vcaA:
1.8		 5vlmC-2vcaA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 LEU A 202
ALA A 250
TYR A 265
PRO A 267
VAL A 327
 None
 1.13A 6b89A-2vcaA:
0.6		 6b89A-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 10 LEU A 202
ALA A 250
TYR A 265
PRO A 267
VAL A 327
 None
 1.00A 6b89B-2vcaA:
0.5		 6b89B-2vcaA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		5 / 12 GLY A  32
VAL A 152
ILE A 132
GLY A 130
ILE A  29
 None
 0.85A 6dh6A-2vcaA:
undetectable		 6dh6A-2vcaA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Clostridium
perfringens) 		3 / 3 ASP A 289
LEU A 223
ARG A 285
 None
 0.89A 7dfrA-2vcaA:
undetectable		 7dfrA-2vcaA:
13.95