SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_L_NCTL1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		4 / 7 TYR A  27
CYH A 159
TYR A 167
TRP A  24
 None
 1.40A 1uw6L-2vclA:
0.0
1uw6M-2vclA:
0.0		 1uw6L-2vclA:
20.83
1uw6M-2vclA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		3 / 3 SER A  84
TYR A 211
ASP A  58
 None
GOL  A1235 ( 4.7A)
None
 0.77A 4rp8C-2vclA:
undetectable		 4rp8C-2vclA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		5 / 11 ILE A 182
ASN A 184
ASP A  98
PRO A 100
TYR A 127
 None
 1.47A 4rtrA-2vclA:
undetectable		 4rtrA-2vclA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		5 / 12 TYR A 178
LEU A  72
THR A  95
ILE A 182
MET A 181
 None
 0.96A 5ifuA-2vclA:
undetectable		 5ifuA-2vclA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		4 / 8 TYR A  27
CYH A 159
TYR A 167
TRP A  24
 None
 1.38A 5kxiA-2vclA:
undetectable
5kxiB-2vclA:
undetectable		 5kxiA-2vclA:
22.22
5kxiB-2vclA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		4 / 8 TRP A  47
THR A  62
ARG A  75
TRP A  44
 None
 1.19A 5tzoA-2vclA:
undetectable		 5tzoA-2vclA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		4 / 8 TRP A  47
THR A  62
ARG A  75
TRP A  44
 None
 1.28A 5tzoB-2vclA:
undetectable		 5tzoB-2vclA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 2vcl CYANOBACTERIAL
PHYCOERYTHROBILIN
(Prochlorococcus
phage
P-SSM2) 		4 / 8 TRP A  47
THR A  62
ARG A  75
TRP A  44
 None
 1.21A 5tzoC-2vclA:
undetectable		 5tzoC-2vclA:
20.49