SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vcy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 LEU A 261
LEU A 175
ALA A 205
ILE A 201
ALA A 199
 None
 1.08A 2bxcA-2vcyA:
undetectable		 2bxcA-2vcyA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 8 GLY A 165
GLU A 107
GLY A 108
ALA A 161
ALA A 162
 None
 1.47A 2ej3C-2vcyA:
undetectable		 2ej3C-2vcyA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 136
ALA A  45
LEU A  46
ALA A 133
 None
 1.04A 2yvlA-2vcyA:
6.1		 2yvlA-2vcyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 136
ALA A  45
LEU A  46
ALA A 133
 None
 1.05A 2yvlB-2vcyA:
6.5		 2yvlB-2vcyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 105
GLY A 136
ALA A  45
LEU A  46
ALA A 133
 None
 1.05A 2yvlD-2vcyA:
6.4		 2yvlD-2vcyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 108
ALA A 131
ALA A 148
LEU A 135
TRP A 138
 None
 0.92A 3p2kA-2vcyA:
4.9		 3p2kA-2vcyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 108
ALA A 131
ALA A 148
LEU A 135
TRP A 138
 None
 0.89A 3p2kC-2vcyA:
4.7		 3p2kC-2vcyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 GLY A 108
ALA A 131
ALA A 148
LEU A 135
TRP A 138
 None
 0.80A 3p2kD-2vcyA:
4.4		 3p2kD-2vcyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		4 / 7 ASN A 190
ALA A 191
SER A 192
VAL A 200
 None
SO4  A1378 (-3.6A)
None
None
 1.09A 4ijiH-2vcyA:
undetectable		 4ijiH-2vcyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		4 / 7 ALA A 171
ILE A 335
LEU A 340
ILE A 129
 None
 0.88A 6b5vA-2vcyA:
undetectable
6b5vB-2vcyA:
undetectable		 6b5vA-2vcyA:
13.68
6b5vB-2vcyA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 VAL A 196
GLY A 108
ALA A  79
ASN A  83
SER A  85
 None
None
None
SO4  A1377 ( 4.9A)
None
 1.15A 6bqgA-2vcyA:
undetectable		 6bqgA-2vcyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2vcy TRANS-2-ENOYL-COA
REDUCTASE
(Homo
sapiens) 		5 / 12 ALA A 206
LEU A 340
VAL A 152
LEU A 175
ALA A 171
 None
 1.07A 6djzC-2vcyA:
undetectable		 6djzC-2vcyA:
22.05