SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vdc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 PHE A 144
LEU A 148
ALA A  72
LEU A  71
ILE A  97
None
0.92A 1crbA-2vdcA:
2.5
1crbA-2vdcA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.68A 1d4yB-2vdcA:
undetectable
1d4yB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A 977
VAL A 998
ALA A1018
ILE A1021
ILE A1023
None
1.03A 1epbA-2vdcA:
undetectable
1epbA-2vdcA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A 977
VAL A 998
ALA A1018
ILE A1021
ILE A1023
None
0.92A 1epbB-2vdcA:
undetectable
1epbB-2vdcA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 GLY A1334
LEU A1300
VAL A1327
PHE A1337
None
1.01A 1gsfC-2vdcA:
undetectable
1gsfC-2vdcA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 SER A 718
VAL A 715
SER A 714
ASN A 348
None
1.26A 1hwkA-2vdcA:
4.6
1hwkA-2vdcA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A 713
GLY A 660
GLY A 722
LEU A 658
VAL A 666
None
1.18A 1i9gA-2vdcA:
undetectable
1i9gA-2vdcA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_A_ACRA700_1
(GLUCOAMYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.30A 1lf9A-2vdcA:
0.0
1lf9A-2vdcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LF9_B_ACRB701_1
(GLUCOAMYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.24A 1lf9B-2vdcA:
0.0
1lf9B-2vdcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 GLY A 361
ILE A 380
GLU A 381
ARG A 402
None
0.88A 1mrjA-2vdcA:
undetectable
1mrjA-2vdcA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 625
VAL A 604
LEU A 642
LEU A 606
LEU A 586
None
1.03A 1mx1F-2vdcA:
undetectable
1mx1F-2vdcA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A 928
ALA A 994
ARG A1245
PHE A1257
ILE A 990
None
1.22A 1mx8A-2vdcA:
undetectable
1mx8A-2vdcA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLY G 441
ALA G 453
ALA G 439
ASP G 442
ILE G 443
FAD  G 484 (-3.4A)
FAD  G 484 (-3.6A)
None
FAD  G 484 (-3.1A)
None
1.16A 1nt2A-2vdcG:
undetectable
1nt2A-2vdcG:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.38A 1q23E-2vdcA:
undetectable
1q23E-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.38A 1q23F-2vdcA:
undetectable
1q23F-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.42A 1q23I-2vdcA:
undetectable
1q23I-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.34A 1q23K-2vdcA:
undetectable
1q23K-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 PRO A 467
MET A 468
ALA A 699
GLU A 474
None
1.24A 1qhyA-2vdcA:
undetectable
1qhyA-2vdcA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.08A 1rjdA-2vdcA:
undetectable
1rjdA-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.07A 1rjdB-2vdcA:
undetectable
1rjdB-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLN A 187
ALA A  33
GLY A  43
GLY A  41
CYH A   1
None
None
None
None
OMT  A2473 (-3.8A)
1.05A 1rjdC-2vdcA:
undetectable
1rjdC-2vdcA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 GLY A 729
ASP A1180
GLY A 753
ILE A 754
ALA A 733
None
1.03A 1sh9B-2vdcA:
undetectable
1sh9B-2vdcA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 PHE A 281
VAL A 342
GLY A 343
VAL A 299
None
0.94A 1t88A-2vdcA:
undetectable
1t88A-2vdcA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 11 GLY G 192
PRO G 191
TYR G  32
ILE G  97
ARG G  96
None
None
None
FAD  G 484 (-3.5A)
None
1.38A 1tmxA-2vdcG:
undetectable
1tmxA-2vdcG:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLY G 192
PRO G 191
TYR G  32
ILE G  97
ARG G  96
None
None
None
FAD  G 484 (-3.5A)
None
1.35A 1tmxB-2vdcG:
undetectable
1tmxB-2vdcG:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ULV_A_ACRA3000_1
(GLUCODEXTRANASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A1295
ASP A 986
GLU A 978
ASN A 231
ARG A  31
None
None
OMT  A2473 ( 4.9A)
OMT  A2473 (-4.0A)
None
1.12A 1ulvA-2vdcA:
0.0
1ulvA-2vdcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 ILE A 713
VAL A1013
ILE A1006
ILE A1021
None
0.78A 1uwhA-2vdcA:
undetectable
1uwhA-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 ILE A 713
VAL A1013
ILE A1006
ILE A1021
None
0.78A 1uwhB-2vdcA:
undetectable
1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 ILE A 716
VAL A 715
VAL A 294
ILE A 532
None
0.87A 1uwhB-2vdcA:
undetectable
1uwhB-2vdcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.43A 1vhwA-2vdcA:
undetectable
1vhwD-2vdcA:
undetectable
1vhwA-2vdcA:
10.85
1vhwD-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_B_ADNB252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.44A 1vhwB-2vdcA:
undetectable
1vhwF-2vdcA:
undetectable
1vhwB-2vdcA:
10.85
1vhwF-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_C_ADNC252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ARG A 351
GLY A 366
VAL A   3
GLU A 978
HIS A  30
None
None
None
OMT  A2473 ( 4.9A)
None
1.44A 1vhwC-2vdcA:
undetectable
1vhwE-2vdcA:
undetectable
1vhwC-2vdcA:
10.85
1vhwE-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_D_ADND252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.45A 1vhwA-2vdcA:
undetectable
1vhwD-2vdcA:
undetectable
1vhwA-2vdcA:
10.85
1vhwD-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.43A 1vhwC-2vdcA:
undetectable
1vhwE-2vdcA:
undetectable
1vhwC-2vdcA:
10.85
1vhwE-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_F_ADNF252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 HIS A  30
ARG A 351
GLY A 366
VAL A   3
GLU A 978
None
None
None
None
OMT  A2473 ( 4.9A)
1.44A 1vhwB-2vdcA:
undetectable
1vhwF-2vdcA:
undetectable
1vhwB-2vdcA:
10.85
1vhwF-2vdcA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 480
GLY A1029
GLY A1031
PHE A 778
SER A1027
None
FMN  A2474 (-3.3A)
AKG  A2475 ( 3.9A)
None
FMN  A2474 ( 4.9A)
1.20A 1wg8A-2vdcA:
undetectable
1wg8A-2vdcA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 THR A1244
GLY A1277
GLY A1297
GLY A1299
ASP A 986
None
1.09A 1wg8B-2vdcA:
undetectable
1wg8B-2vdcA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 PHE A 498
PHE A 739
LEU A 586
PHE A 499
None
1.06A 1wrlE-2vdcA:
undetectable
1wrlE-2vdcA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 GLY A 869
ALA A 867
LEU A 871
PHE A1128
LEU A1097
None
1.44A 1y7iA-2vdcA:
undetectable
1y7iA-2vdcA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 LYS A 431
VAL A 430
THR A 424
LEU A 545
None
0.99A 1z2bB-2vdcA:
2.3
1z2bB-2vdcA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 5 LEU G 262
ASP G 263
GLY G 252
ALA G 245
None
0.97A 2aohA-2vdcG:
undetectable
2aohA-2vdcG:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 GLY A1273
ALA A1272
ASP A1291
VAL A1307
ILE A1322
GLY A1324
None
1.26A 2avoB-2vdcA:
undetectable
2avoB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1286
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
0.81A 2avsA-2vdcA:
undetectable
2avsA-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1286
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
0.76A 2avvD-2vdcA:
undetectable
2avvD-2vdcA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 LEU A 606
LEU A 642
SER A 634
LEU A 631
ARG A 590
None
1.09A 2ceoA-2vdcA:
undetectable
2ceoA-2vdcA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 LEU A 606
LEU A 642
SER A 634
LEU A 631
ARG A 590
None
1.10A 2ceoB-2vdcA:
undetectable
2ceoB-2vdcA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 SER A1247
SER A1248
THR A1251
ASN A 923
None
1.01A 2i91A-2vdcA:
undetectable
2i91A-2vdcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 SER A1247
SER A1248
THR A1251
ASN A 923
None
1.02A 2i91B-2vdcA:
undetectable
2i91B-2vdcA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
ILE A1322
GLY A1324
None
1.44A 2nmzA-2vdcA:
undetectable
2nmzA-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
ILE A1322
GLY A1324
None
1.44A 2nmzB-2vdcA:
undetectable
2nmzB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLY G 184
ALA G 155
GLY G 154
ALA G 239
LEU G 195
FAD  G 484 (-3.4A)
FAD  G 484 ( 4.4A)
FAD  G 484 (-3.0A)
FAD  G 484 (-4.8A)
None
0.94A 2nyuA-2vdcG:
4.1
2nyuA-2vdcG:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 GLY A 649
ASP A 608
VAL A 666
LEU A 658
None
0.84A 2oa1B-2vdcA:
undetectable
2oa1B-2vdcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIV_A_T3A933_1
(ANDROGEN RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 ILE A 974
GLY A1012
TYR A 211
GLU A 978
ARG A 351
None
None
None
OMT  A2473 ( 4.9A)
None
1.18A 2pivA-2vdcA:
0.0
2pivA-2vdcA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A933_1
(ANDROGEN RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ILE A 974
GLY A1012
TYR A 211
GLU A 978
ARG A 351
None
None
None
OMT  A2473 ( 4.9A)
None
1.28A 2piwA-2vdcA:
undetectable
2piwA-2vdcA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ASP A 993
ASN A 991
THR A1244
None
0.77A 2q63B-2vdcA:
undetectable
2q63B-2vdcA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
VAL A1307
ILE A1322
GLY A1324
None
1.48A 2q64B-2vdcA:
undetectable
2q64B-2vdcA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 LEU A1286
ILE A1284
GLY A1303
GLY A1334
SER A1275
None
1.12A 2qmmA-2vdcA:
undetectable
2qmmA-2vdcA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 VAL A 657
GLY A 662
ALA A 727
PHE A 499
GLY A 660
ILE A 632
None
1.40A 2v0zO-2vdcA:
undetectable
2v0zO-2vdcA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ARG A 914
GLY A 916
SER A 905
None
0.65A 2xctB-2vdcA:
2.3
2xctB-2vdcA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 4 ARG A1125
GLY A1116
GLU A 866
SER A 478
None
1.18A 2xctS-2vdcA:
2.7
2xctU-2vdcA:
undetectable
2xctS-2vdcA:
19.48
2xctU-2vdcA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ALA A 616
LEU A 495
LEU A 622
LEU A 582
LEU A 734
None
1.00A 2xn5A-2vdcA:
undetectable
2xn5A-2vdcA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 ILE G  65
TRP G  68
VAL G 123
CYH G 104
SF4  G 483 (-4.7A)
None
None
SF4  G 482 (-2.4A)
0.95A 2xz5A-2vdcG:
undetectable
2xz5C-2vdcG:
undetectable
2xz5A-2vdcG:
18.74
2xz5C-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 ILE G  65
TRP G  68
VAL G 123
CYH G 104
SF4  G 483 (-4.7A)
None
None
SF4  G 482 (-2.4A)
0.94A 2xz5C-2vdcG:
undetectable
2xz5D-2vdcG:
undetectable
2xz5C-2vdcG:
18.74
2xz5D-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 GLU A 927
ARG A 926
ARG A1068
GLU A1089
None
1.04A 2zt7A-2vdcA:
undetectable
2zt7A-2vdcA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 ILE A1405
ARG A 515
MET A1387
THR A1388
None
1.10A 3abkN-2vdcA:
undetectable
3abkW-2vdcA:
undetectable
3abkN-2vdcA:
16.62
3abkW-2vdcA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 LYS A1074
THR A1094
VAL A 817
GLY A 789
ILE A1098
None
FMN  A2474 (-3.7A)
None
None
None
1.48A 3bexC-2vdcA:
undetectable
3bexD-2vdcA:
undetectable
3bexC-2vdcA:
10.12
3bexD-2vdcA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 LYS A1074
THR A1094
VAL A 817
GLY A 789
ILE A1098
None
FMN  A2474 (-3.7A)
None
None
None
1.41A 3bexE-2vdcA:
undetectable
3bexF-2vdcA:
undetectable
3bexE-2vdcA:
10.12
3bexF-2vdcA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 LYS A1074
THR A1094
VAL A 817
GLY A 789
ILE A1098
None
FMN  A2474 (-3.7A)
None
None
None
1.41A 3bf1C-2vdcA:
undetectable
3bf1D-2vdcA:
undetectable
3bf1C-2vdcA:
10.12
3bf1D-2vdcA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 VAL A  17
VAL A  18
GLY A  21
ARG A  15
None
0.85A 3bjwC-2vdcA:
undetectable
3bjwC-2vdcA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 VAL A  17
VAL A  18
GLY A  21
ARG A  15
None
0.89A 3bjwA-2vdcA:
undetectable
3bjwA-2vdcA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 6 PRO A 352
GLY A 365
GLY A   4
GLY A 366
GLY A   2
None
1.15A 3bogA-2vdcA:
undetectable
3bogC-2vdcA:
0.0
3bogA-2vdcA:
undetectable
3bogC-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 GLY A1277
GLY A1299
GLY A1297
None
0.40A 3bogC-2vdcA:
undetectable
3bogC-2vdcA:
4.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_2
(PROTEASE
(RETROPEPSIN))
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.46A 3bvbB-2vdcA:
undetectable
3bvbB-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 LEU A 829
ALA A1082
LEU A1085
GLN A 824
None
0.91A 3cldB-2vdcA:
undetectable
3cldB-2vdcA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 THR G 314
VAL G 395
ALA G 308
VAL G 358
THR G 357
None
0.96A 3czhA-2vdcG:
undetectable
3czhA-2vdcG:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 GLY A 370
ILE A   6
GLY A 365
THR A 358
VAL A 379
ILE A 374
None
1.13A 3d1xA-2vdcA:
undetectable
3d1xA-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 GLY A 370
ILE A   6
GLY A 365
THR A 358
VAL A 379
ILE A 374
None
1.06A 3d1yA-2vdcA:
undetectable
3d1yA-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 THR A1036
SER A1037
PHE A 725
None
0.90A 3d4sA-2vdcA:
undetectable
3d4sA-2vdcA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A1243
THR A1251
LEU A1286
ALA A1280
SER A1301
None
1.29A 3d91B-2vdcA:
undetectable
3d91B-2vdcA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.38A 3ekvA-2vdcA:
undetectable
3ekvA-2vdcA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
ALA A1272
ASP A1291
VAL A1307
ILE A1322
GLY A1324
None
1.45A 3el5A-2vdcA:
undetectable
3el5A-2vdcA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.66A 3el9A-2vdcA:
undetectable
3el9A-2vdcA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ILE A 177
ILE A 178
GLY A 181
PRO A 126
LEU A 195
None
1.25A 3elzB-2vdcA:
undetectable
3elzB-2vdcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ILE A 177
ILE A 178
GLY A 181
PRO A 126
LEU A 195
None
1.26A 3elzC-2vdcA:
2.0
3elzC-2vdcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 GLY A  74
VAL A  76
ILE A  97
VAL A 133
None
0.89A 3fi0E-2vdcA:
undetectable
3fi0E-2vdcA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 GLY A1007
ILE A1021
VAL A1013
GLN A 505
None
0.85A 3fi0E-2vdcA:
undetectable
3fi0E-2vdcA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 GLY A  74
VAL A  76
ILE A 151
VAL A 133
None
0.79A 3fi0I-2vdcA:
undetectable
3fi0I-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 GLY A1007
ILE A1021
VAL A1013
GLN A 505
None
0.81A 3fi0I-2vdcA:
undetectable
3fi0I-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A1005
LEU A 980
SER A1024
VAL A1013
ILE A 930
None
None
FMN  A2474 ( 4.2A)
None
None
0.97A 3frqB-2vdcA:
undetectable
3frqB-2vdcA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 LEU G 295
GLY G 296
LEU G 399
ALA G 245
ASP G 263
None
1.00A 3gwwA-2vdcG:
undetectable
3gwwA-2vdcG:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 TYR A 696
ILE A 659
ALA A 668
ALA A 620
ILE A 700
None
1.09A 3jayA-2vdcA:
undetectable
3jayA-2vdcA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 TYR A 179
TYR A 192
PHE A 191
GLY A  43
ALA A 222
None
1.32A 3jusB-2vdcA:
undetectable
3jusB-2vdcA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
ILE A1322
GLY A1324
None
1.43A 3k4vA-2vdcA:
undetectable
3k4vA-2vdcA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
7 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
ILE A1322
GLY A1324
None
1.49A 3k4vB-2vdcA:
undetectable
3k4vB-2vdcA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 ARG A 384
ARG A1345
GLY A1364
GLU A1366
None
1.32A 3k9fA-2vdcA:
2.8
3k9fB-2vdcA:
2.8
3k9fC-2vdcA:
undetectable
3k9fA-2vdcA:
16.01
3k9fB-2vdcA:
16.01
3k9fC-2vdcA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 4 PHE A1279
TYR A1295
VAL A1216
LEU A1246
None
1.35A 3keeD-2vdcA:
0.0
3keeD-2vdcA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 PRO A 969
SER A 513
MET A 711
SER A 709
ASP A 328
None
1.36A 3lsfB-2vdcA:
0.0
3lsfE-2vdcA:
0.3
3lsfB-2vdcA:
10.64
3lsfE-2vdcA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 VAL A 644
LEU A 586
ILE A 618
ALA A 620
ALA A 626
None
0.77A 3mdvA-2vdcA:
undetectable
3mdvA-2vdcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_B_CL6B506_1
(CHOLESTEROL
24-HYDROXYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 644
LEU A 586
ILE A 618
ALA A 620
ALA A 626
None
0.78A 3mdvB-2vdcA:
undetectable
3mdvB-2vdcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
ILE A1322
GLY A1324
None
1.46A 3ndtA-2vdcA:
undetectable
3ndtA-2vdcA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 370
ILE A   6
GLY A 365
VAL A 379
ILE A 374
None
0.96A 3nduC-2vdcA:
undetectable
3nduC-2vdcA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 LEU A1268
LEU A1286
GLY A1277
LEU A1211
LEU A1246
None
1.30A 3ndvA-2vdcA:
undetectable
3ndvB-2vdcA:
undetectable
3ndvA-2vdcA:
13.97
3ndvB-2vdcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 GLY A1277
LEU A1211
LEU A1246
LEU A1268
LEU A1286
None
1.31A 3ndvC-2vdcA:
undetectable
3ndvD-2vdcA:
undetectable
3ndvC-2vdcA:
13.97
3ndvD-2vdcA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_B_SAMB770_0
(23S RRNA
METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1259
PHE A1254
GLY A1255
ILE A1264
LEU A1246
None
0.93A 3nk7B-2vdcA:
undetectable
3nk7B-2vdcA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 11 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.44A 3nu3B-2vdcA:
undetectable
3nu3B-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 9 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.42A 3nujB-2vdcA:
undetectable
3nujB-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 9 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.45A 3nuoB-2vdcA:
undetectable
3nuoB-2vdcA:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A1273
ALA A1272
VAL A1307
ILE A1322
GLY A1324
None
0.91A 3oxcA-2vdcA:
undetectable
3oxcA-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 370
ILE A   6
GLY A 365
VAL A 379
ILE A 374
None
0.90A 3oxcB-2vdcA:
undetectable
3oxcB-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 9 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.41A 3oxvC-2vdcA:
undetectable
3oxvC-2vdcA:
5.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.35A 3oy4B-2vdcA:
undetectable
3oy4B-2vdcA:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1142
ALA A1095
ALA A1099
LEU A 798
LEU A1073
None
1.14A 3p5nA-2vdcA:
undetectable
3p5nA-2vdcA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1142
ALA A1095
ALA A1099
LEU A 798
LEU A1073
None
1.12A 3p5nB-2vdcA:
undetectable
3p5nB-2vdcA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 HIS A 971
ARG A 914
GLU A 886
None
None
AKG  A2475 (-4.2A)
1.15A 3qf1A-2vdcA:
undetectable
3qf1A-2vdcA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 ARG A 210
ALA A 332
GLY A 329
ILE A 234
OMT  A2473 (-3.9A)
None
None
None
0.71A 3spkB-2vdcA:
undetectable
3spkB-2vdcA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 PHE A1279
TYR A1295
LEU A1246
None
0.76A 3sueB-2vdcA:
undetectable
3sueB-2vdcA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ASN A 876
ALA A 906
ARG A 926
None
0.85A 3tj7C-2vdcA:
undetectable
3tj7D-2vdcA:
undetectable
3tj7C-2vdcA:
9.07
3tj7D-2vdcA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_B_ROCB801_2
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 370
ILE A   6
GLY A 365
VAL A 379
ILE A 374
None
0.97A 3tkgB-2vdcA:
undetectable
3tkgB-2vdcA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 GLY A 370
ILE A   6
GLY A 365
THR A 358
VAL A 379
ILE A 374
None
1.04A 3tkgC-2vdcA:
undetectable
3tkgC-2vdcA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 LEU A1286
GLY A1273
ALA A1272
ASP A1291
ILE A1322
GLY A1324
None
1.49A 3tl9A-2vdcA:
undetectable
3tl9A-2vdcA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.36A 3u9fI-2vdcA:
undetectable
3u9fI-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.31A 3u9fJ-2vdcA:
undetectable
3u9fK-2vdcA:
undetectable
3u9fJ-2vdcA:
9.58
3u9fK-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 PHE A1254
LEU A1246
VAL A1216
PHE A1223
VAL A1250
None
1.33A 3u9fR-2vdcA:
undetectable
3u9fR-2vdcA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 LEU A1022
ARG A 826
LEU A1073
GLU A1046
VAL A1001
None
1.31A 3ua5A-2vdcA:
0.0
3ua5A-2vdcA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 PRO G 157
ALA G 161
GLY G 159
GLU G 165
ASN G  89
FAD  G 484 (-3.6A)
None
None
None
None
1.24A 3v3oB-2vdcG:
5.5
3v3oB-2vdcG:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 ILE A 131
GLY A  74
PHE A 144
LEU A 148
None
0.84A 3v7pA-2vdcA:
2.7
3v7pA-2vdcA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 4 LEU A 586
ALA A 581
PHE A 573
ASN A 752
None
1.23A 3vasA-2vdcA:
undetectable
3vasA-2vdcA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ALA A  44
LEU A 333
VAL A  28
LEU A  25
GLY A   4
None
1.15A 3zosA-2vdcA:
undetectable
3zosB-2vdcA:
undetectable
3zosA-2vdcA:
12.59
3zosB-2vdcA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 11 PRO G 157
ALA G 161
GLY G 159
GLU G 165
ASN G  89
FAD  G 484 (-3.6A)
None
None
None
None
1.22A 4a6nA-2vdcG:
5.4
4a6nA-2vdcG:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
0.98A 4afgD-2vdcG:
undetectable
4afgE-2vdcG:
undetectable
4afgD-2vdcG:
17.60
4afgE-2vdcG:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
1.04A 4aftD-2vdcG:
undetectable
4aftE-2vdcG:
undetectable
4aftD-2vdcG:
18.74
4aftE-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
3 / 3 ARG G  46
ASP G 101
GLN G 331
None
0.68A 4azsA-2vdcG:
4.1
4azsA-2vdcG:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ASP A 346
GLU A 516
ARG A1345
ASN A1363
TYR A 975
None
1.48A 4b7nA-2vdcA:
undetectable
4b7nA-2vdcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ASP A 346
GLU A 516
ARG A1345
ASN A1363
TYR A 975
None
1.45A 4b7qA-2vdcA:
undetectable
4b7qA-2vdcA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ASP A 346
GLU A 516
ARG A1345
ASN A1363
TYR A 975
None
1.46A 4b7qD-2vdcA:
undetectable
4b7qD-2vdcA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 4 ASN A1350
ALA A1353
GLY A1371
THR A1372
None
1.18A 4bboC-2vdcA:
undetectable
4bboC-2vdcA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 MET A 860
GLY A 861
ARG A 893
GLU A 866
None
AKG  A2475 ( 4.8A)
None
None
1.34A 4bqfA-2vdcA:
undetectable
4bqfA-2vdcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 TRP G  68
VAL G 123
CYH G 104
ILE G  65
None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.7A)
1.08A 4bqtC-2vdcG:
undetectable
4bqtD-2vdcG:
undetectable
4bqtC-2vdcG:
18.74
4bqtD-2vdcG:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ASP A 278
LEU A 271
GLU A 156
ARG A 152
TYR A 149
None
1.43A 4cpzE-2vdcA:
undetectable
4cpzE-2vdcA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 PHE A1346
ALA A1338
GLY A1324
GLY A1343
ILE A1322
None
1.07A 4dcmA-2vdcA:
undetectable
4dcmA-2vdcA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1021
LEU A1000
GLY A1012
SER A 212
ARG A 210
None
None
None
None
OMT  A2473 (-3.9A)
1.13A 4djfB-2vdcA:
8.6
4djfB-2vdcA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.38A 4dqbB-2vdcA:
undetectable
4dqbB-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.41A 4dqeB-2vdcA:
undetectable
4dqeB-2vdcA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 10 LEU A1286
GLY A1273
ALA A1272
ASP A1291
VAL A1307
GLY A1324
None
1.38A 4dqhB-2vdcA:
undetectable
4dqhB-2vdcA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 GLY A1277
ALA A1280
ILE A1284
ILE A1215
ASP A1212
None
0.97A 4dt8A-2vdcA:
undetectable
4dt8A-2vdcA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 GLY A1277
ALA A1280
ILE A1284
ILE A1215
ASP A1212
None
1.01A 4dt8B-2vdcA:
undetectable
4dt8B-2vdcA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ILE A 974
ILE A 977
ILE A 930
ALA A1016
VAL A 932
None
1.15A 4h1nA-2vdcA:
undetectable
4h1nA-2vdcA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 HIS A  58
GLY A 106
ILE A 132
None
0.60A 4k50A-2vdcA:
undetectable
4k50A-2vdcA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 HIS A  58
GLY A 106
ILE A 132
None
0.59A 4k50I-2vdcA:
undetectable
4k50I-2vdcA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A1370
ASN A1350
SER A 959
PHE A 915
LEU A 965
None
1.30A 4kowA-2vdcA:
undetectable
4kowA-2vdcA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A1052
LEU A1056
LEU A1049
LEU A1022
LEU A1000
None
0.90A 4m11B-2vdcA:
undetectable
4m11B-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1023
VAL A1052
LEU A1056
LEU A1049
LEU A1000
None
1.33A 4m11C-2vdcA:
undetectable
4m11C-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A1052
LEU A1056
LEU A1049
LEU A1022
LEU A1000
None
0.87A 4m11C-2vdcA:
undetectable
4m11C-2vdcA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 VAL A 430
ASP A 427
SER A 547
ALA A 557
None
0.85A 4m48A-2vdcA:
undetectable
4m48A-2vdcA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 ASP G 356
VAL G 365
ALA G 392
VAL G 390
THR G 360
None
1.27A 4mm4B-2vdcG:
undetectable
4mm4B-2vdcG:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_0
(NEURAMINIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLU G 196
ARG G 203
SER G 198
ARG G 202
ALA G 131
None
1.30A 4mx0A-2vdcG:
undetectable
4mx0A-2vdcG:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A 831
ILE A1149
ARG A1077
ALA A1082
VAL A1161
None
1.01A 4nkvA-2vdcA:
undetectable
4nkvA-2vdcA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A 831
ILE A1149
ARG A1077
ALA A1082
VAL A1161
None
0.97A 4nkvD-2vdcA:
undetectable
4nkvD-2vdcA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ALA A 571
ILE A 754
ALA A 620
ALA A 626
ILE A 589
None
0.92A 4nkxB-2vdcA:
undetectable
4nkxB-2vdcA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 PRO A 326
GLU A 325
ASN A 528
GLY A 527
LEU A 526
None
1.46A 4oadA-2vdcA:
undetectable
4oadA-2vdcA:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 LEU A1000
GLY A1012
ALA A  33
ALA A1016
ASN A1017
None
1.40A 4pclB-2vdcA:
2.1
4pclB-2vdcA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 ASP G 442
VAL G 242
GLY G 441
PHE G  90
GLY G 184
FAD  G 484 (-3.1A)
None
FAD  G 484 (-3.4A)
None
FAD  G 484 (-3.4A)
1.42A 4pevB-2vdcG:
5.4
4pevB-2vdcG:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLU G 201
ASP G 275
LEU G 195
LEU G 186
GLY G 183
None
1.48A 4pfjB-2vdcG:
3.8
4pfjB-2vdcG:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 LEU G 148
GLY G 147
GLU G 145
ALA G 163
None
0.88A 4rjdA-2vdcG:
undetectable
4rjdB-2vdcG:
undetectable
4rjdA-2vdcG:
11.46
4rjdB-2vdcG:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 GLU A 886
SER A1033
GLU A 940
ASP A 651
AKG  A2475 (-4.2A)
None
None
None
1.32A 4uacA-2vdcA:
undetectable
4uacA-2vdcA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ALA A 392
TRP A 340
VAL A 341
None
0.36A 4w9nC-2vdcA:
undetectable
4w9nC-2vdcA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 GLY A 494
LEU A 658
ALA A 620
ASP A 608
ALA A 617
None
1.06A 4wnuD-2vdcA:
undetectable
4wnuD-2vdcA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ALA A1342
VAL A1394
ASP A1396
GLY A1364
PHE A1383
None
1.16A 4xp4A-2vdcA:
undetectable
4xp4A-2vdcA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 299
LEU A 410
LEU A 406
VAL A 342
MET A 335
None
0.99A 4y0sA-2vdcA:
undetectable
4y0sA-2vdcA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 THR A1332
GLY A1302
GLY A1303
ILE A1284
None
0.65A 4yjiA-2vdcA:
undetectable
4yjiA-2vdcA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 ARG A1003
GLY A1042
GLU A 726
SER A1033
None
1.29A 4z3oA-2vdcA:
2.9
4z3oB-2vdcA:
3.1
4z3oA-2vdcA:
19.61
4z3oB-2vdcA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 VAL A 758
PHE A 498
LEU A 730
GLY A 494
LEU A 622
None
1.31A 4zbqA-2vdcA:
undetectable
4zbqA-2vdcA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 8 ALA G 440
GLY G 457
ALA G 162
GLY G 159
None
0.68A 4zjzA-2vdcG:
undetectable
4zjzA-2vdcG:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 ILE A 605
PHE A 555
ARG A 559
GLU A 609
None
1.38A 4zzcB-2vdcA:
undetectable
4zzcC-2vdcA:
undetectable
4zzcB-2vdcA:
12.29
4zzcC-2vdcA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 THR A1317
HIS A1426
LEU A1444
None
0.82A 5axdC-2vdcA:
undetectable
5axdC-2vdcA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 SER A 478
ARG A1125
GLY A1116
GLU A 866
None
1.02A 5cdqA-2vdcA:
3.1
5cdqB-2vdcA:
undetectable
5cdqC-2vdcA:
2.9
5cdqA-2vdcA:
15.83
5cdqB-2vdcA:
8.49
5cdqC-2vdcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 SER A 478
ARG A1125
GLY A1116
GLU A 866
None
1.01A 5cdqR-2vdcA:
undetectable
5cdqS-2vdcA:
undetectable
5cdqT-2vdcA:
3.3
5cdqR-2vdcA:
15.83
5cdqS-2vdcA:
8.49
5cdqT-2vdcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 PHE A 498
ILE A 754
GLY A 494
ILE A 749
None
0.82A 5dzkB-2vdcA:
1.9
5dzkI-2vdcA:
undetectable
5dzkW-2vdcA:
undetectable
5dzkB-2vdcA:
9.76
5dzkI-2vdcA:
8.34
5dzkW-2vdcA:
0.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 PHE A 498
ILE A 754
GLY A 494
ILE A 749
None
0.86A 5dzkd-2vdcA:
2.3
5dzkk-2vdcA:
1.0
5dzky-2vdcA:
undetectable
5dzkd-2vdcA:
9.76
5dzkk-2vdcA:
8.34
5dzky-2vdcA:
0.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 7 GLY G 370
SER G 386
GLY G 385
ALA G 372
None
0.99A 5e26A-2vdcG:
undetectable
5e26B-2vdcG:
undetectable
5e26A-2vdcG:
21.69
5e26B-2vdcG:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 PRO A 969
ILE A 977
SER A 513
None
0.74A 5fsaA-2vdcA:
undetectable
5fsaA-2vdcA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ARG A 957
GLY A 942
GLY A 939
GLY A 913
HIS A 971
AKG  A2475 (-2.8A)
AKG  A2475 (-3.0A)
None
None
None
1.14A 5hikA-2vdcA:
undetectable
5hikA-2vdcA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 942
GLY A 939
GLY A 913
SER A 912
HIS A 971
AKG  A2475 (-3.0A)
None
None
None
None
1.26A 5hikA-2vdcA:
undetectable
5hikA-2vdcA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 7 CYH G  98
ILE G  93
LEU G 449
ALA G 453
SF4  G 482 (-2.5A)
None
FAD  G 484 (-3.9A)
FAD  G 484 (-3.6A)
0.94A 5hrqE-2vdcG:
undetectable
5hrqF-2vdcG:
undetectable
5hrqJ-2vdcG:
undetectable
5hrqE-2vdcG:
5.84
5hrqF-2vdcG:
5.63
5hrqJ-2vdcG:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_A_51GA600_1
(BIFUNCTIONAL AAC/APH)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ASP A 701
SER A 547
ASP A 702
GLU A 554
GLU A 438
None
1.27A 5iqgA-2vdcA:
0.0
5iqgA-2vdcA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_B_51GB600_1
(BIFUNCTIONAL AAC/APH)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ASP A 701
SER A 547
ASP A 702
GLU A 554
GLU A 438
None
1.29A 5iqgB-2vdcA:
1.0
5iqgB-2vdcA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQG_D_51GD600_1
(BIFUNCTIONAL AAC/APH)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 10 ASP A 701
SER A 547
ASP A 702
GLU A 554
GLU A 438
None
1.25A 5iqgD-2vdcA:
0.3
5iqgD-2vdcA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 7 LEU A1061
GLU A1088
ASN A1017
ILE A 984
None
1.17A 5jh7C-2vdcA:
2.3
5jh7C-2vdcA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 8 SER A 641
THR A 640
THR A 602
ARG A 559
ILE A 605
None
1.40A 5jhdE-2vdcA:
undetectable
5jhdG-2vdcA:
undetectable
5jhdE-2vdcA:
10.50
5jhdG-2vdcA:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
6 / 12 GLY A 370
ILE A   6
GLY A 365
THR A 358
VAL A 379
ILE A 374
None
1.07A 5kqxA-2vdcA:
undetectable
5kqxA-2vdcA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ALA A 567
VAL A 604
GLY A 600
GLY A 599
ALA A 596
None
0.95A 5lf7K-2vdcA:
undetectable
5lf7L-2vdcA:
2.8
5lf7K-2vdcA:
10.05
5lf7L-2vdcA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 11 ALA A 567
VAL A 604
GLY A 600
GLY A 599
ALA A 596
None
0.95A 5lf7Y-2vdcA:
undetectable
5lf7Z-2vdcA:
undetectable
5lf7Y-2vdcA:
10.05
5lf7Z-2vdcA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 HIS A 208
LEU A 228
GLY A 275
SER A 272
None
None
None
OMT  A2473 ( 3.8A)
0.91A 5m8rC-2vdcA:
undetectable
5m8rC-2vdcA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1149
LEU A 831
SER A 814
GLY A1076
ASP A1078
None
1.15A 5nnaA-2vdcA:
undetectable
5nnaA-2vdcA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1149
LEU A 831
SER A 814
GLY A1076
ASP A1078
None
1.12A 5nnaB-2vdcA:
undetectable
5nnaB-2vdcA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1149
LEU A 831
SER A 814
GLY A1076
ASP A1078
None
1.10A 5nnaC-2vdcA:
undetectable
5nnaC-2vdcA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 ILE A1149
LEU A 831
SER A 814
GLY A1076
ASP A1078
None
1.14A 5nnaD-2vdcA:
undetectable
5nnaD-2vdcA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_D_D16D402_1
(THYMIDYLATE SYNTHASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 ARG A 450
ILE A 675
ASP A 651
LEU A 650
None
0.88A 5nooD-2vdcA:
undetectable
5nooD-2vdcA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O87_A_NCTA601_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 10 TRP G  68
VAL G 123
CYH G 104
VAL G 118
ILE G  65
None
None
SF4  G 482 (-2.4A)
SF4  G 483 (-4.1A)
SF4  G 483 (-4.7A)
1.35A 5o87A-2vdcG:
0.0
5o87B-2vdcG:
0.0
5o87A-2vdcG:
10.04
5o87B-2vdcG:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 HIS A 653
HIS A 496
HIS A 497
None
0.95A 5oexA-2vdcA:
undetectable
5oexA-2vdcA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 GLY A1283
LEU A1259
HIS A1263
None
0.71A 5u63A-2vdcA:
undetectable
5u63A-2vdcA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 GLY A 477
THR A 950
PRO A 945
None
0.62A 5v5zA-2vdcA:
undetectable
5v5zA-2vdcA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ARG A 590
PHE A 639
LEU A 642
None
0.81A 5veuA-2vdcA:
undetectable
5veuA-2vdcA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 GLU G 219
ASN G 408
ASP G 411
VAL G 236
LEU G 237
FAD  G 484 (-2.9A)
FAD  G 484 (-4.2A)
None
None
None
1.20A 5vooF-2vdcG:
2.3
5vooF-2vdcG:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 8 VAL A   3
HIS A 230
GLN A 209
GLY A  43
None
0.76A 5w3jB-2vdcA:
undetectable
5w3jB-2vdcA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_2
(RIBOFLAVIN LYASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 5 ASN A 235
ASP A 328
SER A 714
ARG A 347
None
1.27A 5w4zA-2vdcA:
7.0
5w4zA-2vdcA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 372
GLY A   4
GLY A 365
ALA A 229
GLN A 223
None
None
None
None
OMT  A2473 (-4.3A)
0.97A 5x7fA-2vdcA:
undetectable
5x7fA-2vdcA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 VAL A 372
GLY A   4
GLY A 366
ALA A 229
GLN A 223
None
None
None
None
OMT  A2473 (-4.3A)
0.72A 5x7fA-2vdcA:
undetectable
5x7fA-2vdcA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 GLU A1450
TYR A1395
GLY A1377
GLY A1359
None
0.91A 5x7pB-2vdcA:
undetectable
5x7pB-2vdcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ASP A 408
ARG A 404
ASP A 311
None
0.77A 5zvgA-2vdcA:
undetectable
5zvgA-2vdcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 ASP A 408
ARG A 404
ASP A 311
None
0.75A 5zvgB-2vdcA:
undetectable
5zvgB-2vdcA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
5 / 12 VAL G  83
LEU G 449
ARG G 203
VAL G 450
GLY G 121
None
FAD  G 484 (-3.9A)
None
FAD  G 484 (-3.7A)
SF4  G 482 ( 4.0A)
1.25A 6brdA-2vdcG:
6.4
6brdA-2vdcG:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
3 / 3 GLY A1028
ASP A1070
ILE A1092
FMN  A2474 (-3.5A)
FMN  A2474 (-3.1A)
None
0.61A 6dgxB-2vdcA:
undetectable
6dgxB-2vdcA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 12 GLY A 370
ILE A   6
GLY A 365
VAL A 379
ILE A 374
None
0.95A 6dh6A-2vdcA:
undetectable
6dh6A-2vdcA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
5 / 9 LEU A 362
THR A 358
ILE A 374
VAL A 372
ILE A 364
None
1.20A 6ef6A-2vdcA:
undetectable
6ef6A-2vdcA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense)
4 / 6 ILE A 177
TYR A 179
VAL A  73
SER A 171
None
1.27A 6f6jA-2vdcA:
undetectable
6f6jA-2vdcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MVX_A_K4DA1304_0
(ION TRANSPORT
PROTEIN)
2vdc GLUTAMATE SYNTHASE
[NADPH] SMALL CHAIN

(Azospirillum
brasilense)
4 / 6 THR G 266
LEU G 265
THR G 276
LEU G 285
None
FAD  G 484 (-4.7A)
None
None
1.03A 6mvxA-2vdcG:
undetectable
6mvxB-2vdcG:
undetectable
6mvxC-2vdcG:
undetectable
6mvxA-2vdcG:
20.54
6mvxB-2vdcG:
20.54
6mvxC-2vdcG:
20.54