SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		3 / 3 TRP A 121
HIS A 152
MET A 128
 None
 1.41A 1l5qB-2vdjA:
2.5		 1l5qB-2vdjA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		5 / 9 GLU A 171
LEU A 186
HIS A 220
HIS A 191
GLY A 218
 None
 1.42A 1mjlA-2vdjA:
undetectable
1mjlB-2vdjA:
undetectable		 1mjlA-2vdjA:
17.39
1mjlB-2vdjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 6 GLY A 144
GLN A 146
VAL A 110
ALA A 108
 None
 0.95A 1p6kA-2vdjA:
undetectable		 1p6kA-2vdjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		3 / 3 ALA A 145
VAL A 230
TRP A 288
 None
 0.89A 1tkqB-2vdjA:
undetectable		 1tkqB-2vdjA:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 6 LEU A  54
ILE A 141
ILE A 202
LEU A 211
 None
 0.91A 2xkwB-2vdjA:
undetectable		 2xkwB-2vdjA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 7 TYR A 263
CYH A 142
GLU A 237
TYR A 238
 None
HSE  A1298 (-3.3A)
None
None
 1.42A 2xytG-2vdjA:
0.0		 2xytG-2vdjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 7 TYR A 263
CYH A 142
GLU A 237
TYR A 238
 None
HSE  A1298 (-3.3A)
None
None
 1.39A 2xytH-2vdjA:
0.0		 2xytH-2vdjA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		5 / 12 HIS A 140
LEU A 208
ARG A 203
GLY A 224
LEU A 210
 None
 1.25A 3okxA-2vdjA:
undetectable		 3okxA-2vdjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 4 GLY A 227
GLY A 224
THR A 209
LEU A 211
 None
 0.89A 3si7C-2vdjA:
undetectable
3si7D-2vdjA:
undetectable		 3si7C-2vdjA:
23.15
3si7D-2vdjA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 6 GLY A 102
VAL A 293
TRP A 288
ASP A 101
 None
 1.18A 3vqrA-2vdjA:
undetectable		 3vqrA-2vdjA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 6 GLU A 199
ILE A 202
GLU A 226
VAL A 177
 None
 0.83A 4ejwB-2vdjA:
undetectable		 4ejwB-2vdjA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		3 / 3 MET A  44
HIS A 235
GLY A 144
 HSE  A1298 ( 3.8A)
HSE  A1298 (-3.9A)
None
 0.75A 5gwzB-2vdjA:
undetectable		 5gwzB-2vdjA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 7 LEU A  54
HIS A 152
THR A 138
HIS A 151
 None
 1.19A 5w97C-2vdjA:
undetectable
5w97a-2vdjA:
undetectable
5w97c-2vdjA:
undetectable		 5w97C-2vdjA:
20.94
5w97a-2vdjA:
20.08
5w97c-2vdjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 8 HIS A 152
THR A 138
HIS A 151
LEU A  54
 None
 1.15A 5x19A-2vdjA:
undetectable
5x19C-2vdjA:
undetectable
5x19P-2vdjA:
undetectable		 5x19A-2vdjA:
20.08
5x19C-2vdjA:
20.94
5x19P-2vdjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 7 HIS A 152
THR A 138
HIS A 151
LEU A  54
 None
 1.09A 5x1bA-2vdjA:
undetectable
5x1bC-2vdjA:
undetectable
5x1bP-2vdjA:
undetectable		 5x1bA-2vdjA:
20.08
5x1bC-2vdjA:
20.94
5x1bP-2vdjA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E
(Bacillus
cereus) 		4 / 8 LEU A  54
HIS A 152
THR A 138
HIS A 151
 None
 1.11A 6nknC-2vdjA:
undetectable
6nknN-2vdjA:
undetectable
6nknP-2vdjA:
undetectable		 6nknC-2vdjA:
20.94
6nknN-2vdjA:
20.08
6nknP-2vdjA:
20.94