SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vdt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 6 ASP A 339
ASN A 242
ASP A 241
TYR A 271
 CA  A1473 (-2.4A)
None
CA  A1473 (-2.6A)
None
 1.07A 1hpkA-2vdtA:
undetectable		 1hpkA-2vdtA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 SER A 359
SER A 334
ASN A 335
ASP A 339
 None
None
None
CA  A1473 (-2.4A)
 1.20A 1hwiB-2vdtA:
undetectable		 1hwiB-2vdtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 SER A 359
SER A 334
ASN A 335
ASP A 339
 None
None
None
CA  A1473 (-2.4A)
 1.14A 1hwkA-2vdtA:
undetectable		 1hwkA-2vdtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 SER A 359
SER A 334
ASN A 335
ASP A 339
 None
None
None
CA  A1473 (-2.4A)
 1.17A 1hwkC-2vdtA:
undetectable		 1hwkC-2vdtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 SER A 359
SER A 334
ASN A 335
ASP A 339
 None
None
None
CA  A1473 (-2.4A)
 1.16A 1hwkD-2vdtA:
undetectable		 1hwkD-2vdtA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 7 TYR A  37
ASN A 335
TYR A 271
GLY A 311
 None
 1.25A 1mxgA-2vdtA:
undetectable		 1mxgA-2vdtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 PHE A 107
ALA A 167
ARG A 176
LEU A  90
 None
 0.79A 2bxkA-2vdtA:
undetectable		 2bxkA-2vdtA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		5 / 12 ILE A 374
GLY A 361
VAL A 337
ASP A 358
GLN A  58
 None
 1.05A 3bwcA-2vdtA:
undetectable		 3bwcA-2vdtA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 6 PHE A 347
TYR A 354
THR A 456
PHE A 356
 None
 1.33A 3ltwA-2vdtA:
undetectable		 3ltwA-2vdtA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA206_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 4 ASP A 247
ARG A 246
THR A 180
ALA A 164
 None
 1.27A 3mbgA-2vdtA:
undetectable		 3mbgA-2vdtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 7 ASP A 247
ARG A 246
THR A 180
ALA A 164
 None
 1.26A 3mbgA-2vdtA:
undetectable
3mbgB-2vdtA:
undetectable		 3mbgA-2vdtA:
15.59
3mbgB-2vdtA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 4 LYS A 137
PHE A 124
PHE A 107
VAL A 197
 None
 1.13A 3rv5A-2vdtA:
undetectable
3rv5B-2vdtA:
undetectable		 3rv5A-2vdtA:
12.59
3rv5B-2vdtA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		3 / 3 THR A 244
ASN A 264
GLU A 262
 None
CA  A1473 (-3.8A)
None
 0.75A 3v4tA-2vdtA:
undetectable
3v4tC-2vdtA:
undetectable		 3v4tA-2vdtA:
20.52
3v4tC-2vdtA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 8 ASP A 339
ASP A 269
ASN A 264
GLU A 262
 CA  A1473 (-2.4A)
None
CA  A1473 (-3.8A)
None
 1.16A 4gkiC-2vdtA:
undetectable		 4gkiC-2vdtA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		3 / 3 PRO A 417
ASN A 345
HIS A 249
 None
 0.82A 4ma3H-2vdtA:
undetectable
4ma3L-2vdtA:
undetectable		 4ma3H-2vdtA:
21.28
4ma3L-2vdtA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		3 / 3 THR A 194
THR A 193
PHE A 218
 None
 0.88A 5cxvA-2vdtA:
undetectable		 5cxvA-2vdtA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		4 / 7 TYR A 187
TYR A 237
GLN A 229
ASP A 233
 None
 1.39A 5ov9B-2vdtA:
undetectable		 5ov9B-2vdtA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		3 / 3 GLY A 222
THR A 267
GLU A 268
 None
 0.62A 6b58A-2vdtA:
undetectable		 6b58A-2vdtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		3 / 3 TYR A 283
ALA A 306
LEU A 297
 None
 0.75A 6d9kF-2vdtA:
undetectable		 6d9kF-2vdtA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 2vdt LEVANSUCRASE
(Bacillus
subtilis) 		5 / 11 THR A 456
ASN A 450
VAL A 380
PHE A 347
VAL A 424
 None
 1.41A 6hcoA-2vdtA:
undetectable
6hcoB-2vdtA:
undetectable		 6hcoA-2vdtA:
22.53
6hcoB-2vdtA:
22.53