SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vdv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 277
GLU E 211
GLY E 212
THR E 282
 None
 1.06A 1ykiA-2vdvE:
undetectable
1ykiB-2vdvE:
undetectable		 1ykiA-2vdvE:
19.92
1ykiB-2vdvE:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 THR E 282
PHE E 277
GLU E 211
GLY E 212
 None
 1.06A 1ykiA-2vdvE:
undetectable
1ykiB-2vdvE:
undetectable		 1ykiA-2vdvE:
19.92
1ykiB-2vdvE:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 PHE E 277
GLU E 211
GLY E 212
THR E 282
 None
 1.07A 1ykiC-2vdvE:
undetectable
1ykiD-2vdvE:
undetectable		 1ykiC-2vdvE:
19.92
1ykiD-2vdvE:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 8 THR E 282
PHE E 277
GLU E 211
GLY E 212
 None
 1.05A 1ykiC-2vdvE:
undetectable
1ykiD-2vdvE:
undetectable		 1ykiC-2vdvE:
19.92
1ykiD-2vdvE:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ASP E 101
GLY E 103
GLY E 105
LEU E 109
ILE E 127
 SAM  E1287 ( 4.9A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.8A)
 0.91A 2nxeA-2vdvE:
10.4		 2nxeA-2vdvE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 4 VAL E 131
THR E 132
VAL E 157
GLY E 124
 None
 1.19A 2p2fB-2vdvE:
2.8		 2p2fB-2vdvE:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLN E 153
TYR E  85
TYR E  82
ILE E  99
 None
 1.24A 2ph9A-2vdvE:
undetectable
2ph9B-2vdvE:
undetectable		 2ph9A-2vdvE:
21.76
2ph9B-2vdvE:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		12 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
CYH E 181
PHE E 182
ASP E 184
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
None
SAM  E1287 (-4.6A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.01A 2vdvE-2vdvE:
40.7		 2vdvE-2vdvE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		11 / 11 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
PHE E 182
ASP E 184
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 (-4.6A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.00A 2vdvF-2vdvE:
40.0		 2vdvF-2vdvE:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		7 / 12 GLY E 103
GLU E 126
ILE E 127
ARG E 128
ASN E 161
ALA E 162
MET E 163
 SAM  E1287 (-3.1A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
 1.04A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		7 / 12 GLY E 103
GLU E 126
ILE E 127
ARG E 128
ASN E 161
MET E 163
ASP E 184
 SAM  E1287 (-3.1A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-4.9A)
SAM  E1287 (-3.4A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-4.0A)
 1.22A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		6 / 12 GLY E 103
GLY E 105
ALA E 162
MET E 163
THR E 259
GLU E 261
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-2.8A)
SAM  E1287 (-2.9A)
 0.87A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
ALA E 162
LEU E 109
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
None
SAM  E1287 (-2.8A)
 1.35A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
ALA E 162
MET E 163
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 (-3.9A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-2.8A)
 0.60A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		8 / 12 GLY E 103
GLY E 105
GLU E 126
ILE E 127
ASN E 161
MET E 163
ASP E 184
THR E 259
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.8A)
SAM  E1287 (-3.4A)
SAM  E1287 ( 4.4A)
SAM  E1287 (-4.0A)
SAM  E1287 (-2.8A)
 0.83A 3ckkA-2vdvE:
29.6		 3ckkA-2vdvE:
53.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 GLY E 103
GLY E 105
GLU E 126
ALA E 162
PHE E 182
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.9A)
SAM  E1287 (-4.6A)
 0.47A 3dxyA-2vdvE:
17.8		 3dxyA-2vdvE:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_1
(DIHYDROFOLATE
REDUCTASE)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA E 100
MET E 125
LEU E 166
ARG E 195
LEU E 201
 None
 1.21A 3ia4B-2vdvE:
undetectable		 3ia4B-2vdvE:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR E 216
THR E 217
PHE E 180
LEU E 109
 None
 1.25A 3qelC-2vdvE:
2.3		 3qelC-2vdvE:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.78A 4uciA-2vdvE:
4.8		 4uciA-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.77A 4uciB-2vdvE:
4.7		 4uciB-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 107
ALA E 162
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
SAM  E1287 (-3.9A)
 0.77A 4uckA-2vdvE:
4.9		 4uckA-2vdvE:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 212
PRO E 281
LEU E 280
LYS E 177
LEU E 241
 None
 1.13A 4x61A-2vdvE:
6.2		 4x61A-2vdvE:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 105
GLY E 107
GLY E 108
LEU E 109
GLU E 126
 SAM  E1287 (-3.6A)
None
None
None
SAM  E1287 (-2.6A)
 0.83A 5c0oF-2vdvE:
10.2		 5c0oF-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 103
GLY E 105
GLY E 108
LEU E 109
ARG E 128
 SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
None
SAM  E1287 (-4.9A)
 0.77A 5c0oG-2vdvE:
12.3		 5c0oG-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 THR E 259
GLY E 103
GLY E 105
GLY E 108
LEU E 109
 SAM  E1287 (-2.8A)
SAM  E1287 (-3.1A)
SAM  E1287 (-3.6A)
None
None
 0.95A 5c0oG-2vdvE:
12.3		 5c0oG-2vdvE:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY E 212
PRO E 281
LEU E 280
LYS E 177
LEU E 241
 None
 1.11A 5emlA-2vdvE:
4.0		 5emlA-2vdvE:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 109
ILE E 111
GLY E 105
LEU E 113
SER E 114
 None
None
SAM  E1287 (-3.6A)
None
None
 0.93A 5twjD-2vdvE:
undetectable		 5twjD-2vdvE:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		5 / 5 PHE E 106
THR E 259
ASP E 101
GLU E 126
ASN E 161
 None
SAM  E1287 (-2.8A)
SAM  E1287 ( 4.9A)
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 1.24A 5ybbA-2vdvE:
6.2		 5ybbA-2vdvE:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vdv TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY E 105
GLY E 107
GLU E 126
ASN E 161
 SAM  E1287 (-3.6A)
None
SAM  E1287 (-2.6A)
SAM  E1287 (-3.4A)
 0.65A 5ybbB-2vdvE:
3.7		 5ybbB-2vdvE:
18.38