SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vdw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_A_ZMRA466_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.48A 1a4gA-2vdwA:
undetectable		 1a4gA-2vdwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4001_1
(SERUM ALBUMIN)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		4 / 4 ARG A 592
LYS A 593
ASP A 588
GLY A 705
 None
 1.41A 1e7bB-2vdwA:
0.0		 1e7bB-2vdwA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 MET A 694
LEU A 697
SER A 698
 None
 0.56A 1ee2A-2vdwA:
6.0		 1ee2A-2vdwA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 LYS A 573
GLY A 600
GLN A 678
PHE A 679
TYR A 683
 SAH  A1846 (-2.9A)
SAH  A1846 (-3.2A)
None
SAH  A1846 (-4.9A)
SAH  A1846 ( 3.7A)
 0.45A 1ri4A-2vdwA:
27.1		 1ri4A-2vdwA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		4 / 4 THR A 756
GLY A 600
ASP A 620
ALA A 680
 None
SAH  A1846 (-3.2A)
SAH  A1846 (-2.6A)
SAH  A1846 (-3.6A)
 1.10A 1sg9A-2vdwA:
11.3		 1sg9A-2vdwA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 SER A 735
SER A 734
HIS A 729
 None
 0.79A 3mzeA-2vdwA:
undetectable		 3mzeA-2vdwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.49A 3ticA-2vdwA:
undetectable		 3ticA-2vdwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.50A 3ticC-2vdwA:
undetectable		 3ticC-2vdwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.50A 3ticD-2vdwA:
undetectable		 3ticD-2vdwA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 SER A 684
ASP A 620
ASP A 624
 None
SAH  A1846 (-2.6A)
None
 0.83A 3uj7A-2vdwA:
16.5		 3uj7A-2vdwA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPN_A_ZMRA700_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.42A 4cpnA-2vdwA:
undetectable		 4cpnA-2vdwA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.45A 4cpzC-2vdwA:
undetectable		 4cpzC-2vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.47A 4cpzE-2vdwA:
undetectable		 4cpzE-2vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.48A 4cpzF-2vdwA:
undetectable		 4cpzF-2vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.47A 4cpzG-2vdwA:
undetectable		 4cpzG-2vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_1
(NEURAMINIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 ARG A 655
ASP A 598
GLU A 652
ALA A 625
ARG A 548
 SAH  A1846 (-3.4A)
SAH  A1846 (-3.1A)
None
SAH  A1846 ( 4.9A)
SAH  A1846 (-3.2A)
 1.47A 4cpzH-2vdwA:
undetectable		 4cpzH-2vdwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		4 / 6 GLY A 563
GLY A 566
ASN A 570
ILE A 728
 None
 0.94A 4fglD-2vdwA:
undetectable		 4fglD-2vdwA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		4 / 4 ILE A 613
VAL A 617
VAL A 594
ARG A 592
 None
 1.25A 4m6tA-2vdwA:
undetectable		 4m6tA-2vdwA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 SER A 684
ASP A 620
ASP A 624
 None
SAH  A1846 (-2.6A)
None
 0.77A 4mwzA-2vdwA:
15.7		 4mwzA-2vdwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 12 GLY A 600
ASN A 601
ASP A 604
ASP A 620
SER A 684
 SAH  A1846 (-3.2A)
SO4  A1845 (-4.1A)
SAH  A1846 ( 4.5A)
SAH  A1846 (-2.6A)
None
 1.05A 4pooB-2vdwA:
11.6		 4pooB-2vdwA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 ASP A 676
ASP A 604
ASN A 601
 SAH  A1846 ( 4.7A)
SAH  A1846 ( 4.5A)
SO4  A1845 (-4.1A)
 0.83A 4q5mA-2vdwA:
undetectable		 4q5mA-2vdwA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		4 / 7 GLY A 704
GLY A 705
ALA A 702
ILE A 674
 None
 0.74A 4yjiA-2vdwA:
undetectable		 4yjiA-2vdwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		3 / 3 PRO A 733
SER A 734
SER A 735
 None
 0.62A 6bpyA-2vdwA:
undetectable		 6bpyA-2vdwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		6 / 11 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
 None
 1.19A 6ebzA-2vdwA:
undetectable		 6ebzA-2vdwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 11 LEU A 700
PHE A 780
PHE A 659
ILE A 654
ILE A 597
 None
 0.95A 6ebzC-2vdwA:
undetectable		 6ebzC-2vdwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		5 / 11 THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
 None
 0.99A 6ebzD-2vdwA:
undetectable		 6ebzD-2vdwA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		6 / 11 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
 None
 1.15A 6gp2A-2vdwA:
undetectable		 6gp2A-2vdwA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT
(Vaccinia
virus) 		6 / 11 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
 None
 1.15A 6gp2B-2vdwA:
undetectable		 6gp2B-2vdwA:
13.06