SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ve3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 403
LEU A 399
MET A 301
LEU A 289
PHE A 266
 None
 1.16A 1a28A-2ve3A:
2.3		 1a28A-2ve3A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 403
LEU A 399
MET A 301
LEU A 289
PHE A 266
 None
 1.21A 1zucB-2ve3A:
2.3		 1zucB-2ve3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.29A 2vdyA-2ve3A:
undetectable		 2vdyA-2ve3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDY_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.08A 2vdyB-2ve3A:
undetectable		 2vdyB-2ve3A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 7 THR A 116
GLN A 110
ILE A 227
SER A 119
 None
 1.23A 2xytI-2ve3A:
undetectable		 2xytI-2ve3A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 11 ILE A 315
LEU A 263
MET A 401
LEU A 269
PRO A 430
 None
None
HEM  A1444 ( 4.3A)
None
None
 1.18A 3a50B-2ve3A:
32.7		 3a50B-2ve3A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 8 PHE A 384
GLY A 385
ASN A  65
ILE A 346
 HEM  A1444 (-4.5A)
HEM  A1444 (-4.0A)
None
None
 0.93A 3aodA-2ve3A:
2.8		 3aodA-2ve3A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A  88
GLN A  96
THR A  95
LEU A 204
 None
 1.19A 3ce6D-2ve3A:
undetectable		 3ce6D-2ve3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 254
THR A 258
CYH A 391
 HEM  A1444 (-3.3A)
HEM  A1444 ( 3.3A)
HEM  A1444 (-2.5A)
 0.63A 3e4eA-2ve3A:
30.0		 3e4eA-2ve3A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 254
THR A 258
CYH A 391
 HEM  A1444 (-3.3A)
HEM  A1444 ( 3.3A)
HEM  A1444 (-2.5A)
 0.53A 3e4eB-2ve3A:
35.0		 3e4eB-2ve3A:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.29A 4c49B-2ve3A:
undetectable		 4c49B-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.35A 4c49C-2ve3A:
undetectable		 4c49C-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 SER A 429
THR A  26
PHE A  52
SER A  83
PHE A  29
 REA  A1445 ( 4.3A)
None
None
None
REA  A1445 (-4.6A)
 1.27A 4c49D-2ve3A:
undetectable		 4c49D-2ve3A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.05A 4d7hA-2ve3A:
undetectable		 4d7hA-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A  69
PHE A 336
ILE A  46
GLY A 320
ALA A  64
 None
None
None
REA  A1445 (-4.5A)
None
 1.11A 4enhA-2ve3A:
41.4		 4enhA-2ve3A:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 422
ASP A 434
ARG A 437
ILE A 142
 None
 1.15A 4mwrA-2ve3A:
undetectable		 4mwrA-2ve3A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A  94
ALA A 254
GLU A 257
THR A 258
 REA  A1445 ( 3.7A)
HEM  A1444 (-3.3A)
None
HEM  A1444 ( 3.3A)
 0.79A 4r1zB-2ve3A:
36.4		 4r1zB-2ve3A:
27.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.12A 4ug5A-2ve3A:
undetectable		 4ug5A-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.05A 4uglA-2ve3A:
undetectable		 4uglA-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 323
THR A  95
TRP A  80
 HEM  A1444 (-2.7A)
None
REA  A1445 ( 3.9A)
 1.07A 5g6cA-2ve3A:
undetectable		 5g6cA-2ve3A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 6 CYH A 267
LEU A 408
HIS A 441
LEU A 440
 None
 1.04A 5hpuC-2ve3A:
undetectable
5hpuD-2ve3A:
undetectable		 5hpuC-2ve3A:
4.84
5hpuD-2ve3A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		4 / 6 LEU A 121
THR A 157
LEU A 403
GLU A 395
 None
 0.93A 5tudD-2ve3A:
1.4		 5tudD-2ve3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 403
VAL A 154
TYR A 120
PHE A 396
LEU A 399
 None
None
None
HEM  A1444 (-4.7A)
None
 1.49A 6eliA-2ve3A:
undetectable		 6eliA-2ve3A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 11 PHE A 174
ILE A 178
LEU A 170
ILE A 248
MET A 160
 None
 1.45A 6fgcA-2ve3A:
undetectable		 6fgcA-2ve3A:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		 2ve3 PUTATIVE CYTOCHROME
P450 120
(Synechocystis
sp.
PCC
6803) 		5 / 11 PHE A 174
ILE A 178
LEU A 170
ILE A 248
MET A 160
 None
 1.47A 6fgdA-2ve3A:
undetectable		 6fgdA-2ve3A:
10.64