SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ve7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		3 / 3 VAL A 186
ALA A 183
HIS A 180
 None
 0.76A 1q23C-2ve7A:
undetectable		 1q23C-2ve7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		3 / 3 VAL A 186
ALA A 183
HIS A 180
 None
 0.78A 1q23L-2ve7A:
undetectable		 1q23L-2ve7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		3 / 3 LYS A 115
ILE A  96
THR A 104
 None
 0.83A 1rx3A-2ve7A:
undetectable		 1rx3A-2ve7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
KINETOCHORE PROTEIN
NUF2, KINETOCHORE
PROTEIN SPC24
(Homo
sapiens;
Homo
sapiens) 		4 / 5 LEU C 155
LYS A 264
LEU A 268
GLU A 269
 None
 1.14A 3h5gA-2ve7C:
undetectable
3h5gB-2ve7C:
undetectable		 3h5gA-2ve7C:
9.55
3h5gB-2ve7C:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
KINETOCHORE PROTEIN
NUF2, KINETOCHORE
PROTEIN SPC24
(Homo
sapiens;
Homo
sapiens) 		5 / 6 LYS C 151
LEU C 155
LYS A 264
LEU A 268
GLU A 269
 None
 1.35A 3h5gB-2ve7C:
undetectable
3h5gC-2ve7C:
undetectable		 3h5gB-2ve7C:
9.55
3h5gC-2ve7C:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
KINETOCHORE PROTEIN
NUF2, KINETOCHORE
PROTEIN SPC24
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG C 131
GLU A 216
THR A 215
 None
 0.89A 3v4tA-2ve7C:
undetectable		 3v4tA-2ve7C:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		3 / 3 LYS A 115
ILE A  96
THR A 104
 None
 0.82A 4gh8A-2ve7A:
undetectable		 4gh8A-2ve7A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		5 / 12 MET A 169
LEU A 164
ALA A 183
LEU A 185
LEU A 188
 None
 1.19A 4m11C-2ve7A:
undetectable		 4m11C-2ve7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		4 / 6 PHE A 129
SER A 113
VAL A 112
ASP A 124
 None
 1.29A 5hesA-2ve7A:
undetectable		 5hesA-2ve7A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		4 / 5 LEU A 224
PHE A 225
LEU A 254
PHE A 258
 None
 1.23A 5iy5P-2ve7A:
undetectable
5iy5W-2ve7A:
undetectable		 5iy5P-2ve7A:
20.62
5iy5W-2ve7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		5 / 12 LEU A 185
LEU A 188
ILE A 189
ILE A 192
LEU A 103
 None
 0.76A 5uanB-2ve7A:
undetectable		 5uanB-2ve7A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		4 / 5 LEU A 224
PHE A 225
LEU A 254
PHE A 258
 None
 1.19A 5x1fC-2ve7A:
undetectable
5x1fJ-2ve7A:
undetectable		 5x1fC-2ve7A:
20.06
5x1fJ-2ve7A:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 2ve7 KINETOCHORE PROTEIN
HEC1, KINETOCHORE
PROTEIN SPC25
(Homo
sapiens) 		4 / 5 LEU A 224
PHE A 225
LEU A 254
PHE A 258
 None
 1.24A 5xdxC-2ve7A:
undetectable
5xdxJ-2ve7A:
undetectable		 5xdxC-2ve7A:
19.14
5xdxJ-2ve7A:
11.86