SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vea'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASP A 171
VAL A 173
HIS A 291
GLY A 169
 None
 1.00A 1ekjA-2veaA:
undetectable
1ekjB-2veaA:
undetectable		 1ekjA-2veaA:
19.11
1ekjB-2veaA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 6 TYR A 137
VAL A 159
ILE A 160
LEU A 301
 None
 1.32A 1j96A-2veaA:
undetectable		 1j96A-2veaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		3 / 3 TRP A  95
ARG A  97
PHE A 103
 None
 1.32A 1zeaH-2veaA:
undetectable
1zeaL-2veaA:
undetectable		 1zeaH-2veaA:
18.00
1zeaL-2veaA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 7 ILE A 429
TRP A 439
LEU A 352
ILE A 370
 None
 0.85A 2q83A-2veaA:
undetectable		 2q83A-2veaA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 8 ASP A 207
TYR A 176
GLY A 184
PRO A 204
 CYC  A1521 (-3.9A)
None
None
None
 0.93A 2ys6A-2veaA:
undetectable		 2ys6A-2veaA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 208
ALA A 212
ALA A 256
LEU A 264
ILE A 224
 CYC  A1521 (-4.0A)
CYC  A1521 ( 3.8A)
CYC  A1521 (-3.9A)
None
None
 0.70A 3uvvA-2veaA:
undetectable		 3uvvA-2veaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		3 / 3 PHE A 136
VAL A 173
ILE A 287
 None
 0.63A 4emaA-2veaA:
undetectable		 4emaA-2veaA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 8 ARG A 165
GLY A 270
ALA A 271
ASP A 226
THR A 168
 None
 1.10A 4eyrB-2veaA:
undetectable		 4eyrB-2veaA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 11 ARG A 165
GLY A 270
ALA A 271
ASP A 226
THR A 168
 None
 1.11A 4l1aA-2veaA:
undetectable		 4l1aA-2veaA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A 177
TRP A 284
ILE A 187
 None
 0.77A 4mwxA-2veaA:
undetectable		 4mwxA-2veaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 5 LEU A 286
GLU A 306
LEU A 215
HIS A 260
 CYC  A1521 ( 4.9A)
None
None
CYC  A1521 (-3.4A)
 1.12A 4xi3B-2veaA:
undetectable		 4xi3B-2veaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A  89
LEU A  35
GLY A  66
SER A  71
LEU A  94
 None
 1.41A 4zbrA-2veaA:
undetectable		 4zbrA-2veaA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 7 ARG A 472
ARG A 172
TYR A 203
TYR A 263
 None
None
CYC  A1521 (-3.9A)
CYC  A1521 (-3.9A)
 1.46A 5a06A-2veaA:
undetectable		 5a06A-2veaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 7 ARG A 472
ARG A 172
TYR A 203
TYR A 263
 None
None
CYC  A1521 (-3.9A)
CYC  A1521 (-3.9A)
 1.48A 5a06C-2veaA:
undetectable		 5a06C-2veaA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 8 SER A 272
ALA A 271
LEU A 264
LEU A 261
 CYC  A1521 ( 3.7A)
None
None
None
 1.05A 5dzkd-2veaA:
undetectable
5dzkr-2veaA:
undetectable		 5dzkd-2veaA:
18.41
5dzkr-2veaA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 6 ALA A 271
VAL A 227
TYR A 228
HIS A 291
 None
 0.90A 5eckA-2veaA:
2.1		 5eckA-2veaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 6 ALA A 271
VAL A 227
TYR A 228
HIS A 291
 None
 0.88A 5eckD-2veaA:
2.0		 5eckD-2veaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 6 ALA A 271
VAL A 227
TYR A 228
HIS A 291
 None
 0.89A 5eclA-2veaA:
undetectable		 5eclA-2veaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 503
ASN A 506
LEU A 507
 None
 0.39A 5i1nB-2veaA:
undetectable		 5i1nB-2veaA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		3 / 3 ALA A 503
ASN A 506
LEU A 507
 None
 0.46A 5i1oA-2veaA:
undetectable		 5i1oA-2veaA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 5 GLY A 184
ARG A 213
ASP A 185
GLN A 446
 None
 1.39A 5ubbA-2veaA:
undetectable		 5ubbA-2veaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 387
ILE A 377
PHE A 440
LEU A 378
 None
 0.88A 6b5vA-2veaA:
undetectable
6b5vB-2veaA:
1.2		 6b5vA-2veaA:
12.07
6b5vB-2veaA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 9 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.25A 6czmA-2veaA:
undetectable
6czmB-2veaA:
undetectable		 6czmA-2veaA:
22.68
6czmB-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 9 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.23A 6czmB-2veaA:
undetectable
6czmC-2veaA:
undetectable		 6czmB-2veaA:
22.68
6czmC-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 9 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.23A 6czmD-2veaA:
undetectable
6czmE-2veaA:
undetectable		 6czmD-2veaA:
22.68
6czmE-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		5 / 10 VAL A 388
VAL A 422
LEU A 391
GLY A 425
LEU A 409
 None
 1.24A 6czmE-2veaA:
undetectable
6czmF-2veaA:
undetectable		 6czmE-2veaA:
22.68
6czmF-2veaA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 2vea PHYTOCHROME-LIKE
PROTEIN CPH1
(Synechocystis
sp.
PCC
6803) 		4 / 4 HIS A 260
VAL A 227
LEU A 264
ALA A 256
 CYC  A1521 (-3.4A)
None
None
CYC  A1521 (-3.9A)
 1.29A 6d8pB-2veaA:
undetectable		 6d8pB-2veaA:
22.02