SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vec'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_B_RALB600_1 (ESTROGEN RECEPTOR)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 12	LEU A 91 LEU A 92 ILE A 143 LEU A 112 LEU A 48	None	1.19A	1errB-2vecA: undetectable	1errB-2vecA: 23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KW0_A_H4BA429_1 (PHENYLALANINE-4-HYDR OXYLASE)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 12	VAL A 42 LEU A 93 THR A 23 TYR A 75 GLU A 103	None	1.06A	1kw0A-2vecA: undetectable	1kw0A-2vecA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MMT_A_H4BA1426_1 (PHENYLALANINE-4-HYDR OXYLASE)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 11	VAL A 42 LEU A 93 THR A 23 TYR A 75 GLU A 103	None	1.06A	1mmtA-2vecA: undetectable	1mmtA-2vecA: 21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OT7_B_IU5B1002_1 (BILE ACID RECEPTOR)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 12	LEU A 69 MET A 137 ILE A 143 ILE A 186 TRP A 17	None	1.19A	1ot7B-2vecA: undetectable	1ot7B-2vecA: 21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_B_STRB2001_1 (MINERALOCORTICOID RECEPTOR)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 12	LEU A 135 GLN A 131 SER A 145 LEU A 155 LEU A 142	None	1.19A	1ya3B-2vecA: undetectable	1ya3B-2vecA: 21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DR2_A_TRPA479_0 (TRYPTOPHANYL-TRNA SYNTHETASE)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	5 / 11	TYR A 22 GLY A 205 GLY A 188 GLN A 184 PHE A 24	None	1.50A	2dr2A-2vecA: undetectable	2dr2A-2vecA: 20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WQ5_A_MIYA1120_1 (PHOSPHOLIPASE A2, ACIDIC)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	4 / 7	LEU A 43 GLY A 205 ARG A 8 PHE A 24	None	0.68A	2wq5A-2vecA: undetectable	2wq5A-2vecA: 20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TE8_C_08JC602_1 (CYTOCHROME P450 3A4)	2vec	PIRIN-LIKE PROTEIN YHAK (Escherichia coli)	4 / 7	LEU A 202 ALA A 192 ILE A 164 LEU A 224	None	0.96A	5te8C-2vecA: undetectable	5te8C-2vecA: 19.92

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1ERR_B_RALB600_1","ESTROGEN RECEPTOR","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"LEU A  91;LEU A  92;ILE A 143;LEU A 112;LEU A  48","None","1.19A","1errB-2vecA:undetectable","1errB-2vecA:23.65"],["1KW0_A_H4BA429_1","PHENYLALANINE-4-HYDROXYLASE","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"VAL A  42;LEU A  93;THR A  23;TYR A  75;GLU A 103","None","1.06A","1kw0A-2vecA:undetectable","1kw0A-2vecA:21.05"],["1MMT_A_H4BA1426_1","PHENYLALANINE-4-HYDROXYLASE","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"VAL A  42;LEU A  93;THR A  23;TYR A  75;GLU A 103","None","1.06A","1mmtA-2vecA:undetectable","1mmtA-2vecA:21.05"],["1OT7_B_IU5B1002_1","BILE ACID RECEPTOR","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"LEU A  69;MET A 137;ILE A 143;ILE A 186;TRP A  17","None","1.19A","1ot7B-2vecA:undetectable","1ot7B-2vecA:21.19"],["1YA3_B_STRB2001_1","MINERALOCORTICOID RECEPTOR","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"LEU A 135;GLN A 131;SER A 145;LEU A 155;LEU A 142","None","1.19A","1ya3B-2vecA:undetectable","1ya3B-2vecA:21.38"],["2DR2_A_TRPA479_0","TRYPTOPHANYL-TRNA SYNTHETASE","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",5,"TYR A  22;GLY A 205;GLY A 188;GLN A 184;PHE A  24","None","1.50A","2dr2A-2vecA:undetectable","2dr2A-2vecA:20.21"],["2WQ5_A_MIYA1120_1","PHOSPHOLIPASE A2, ACIDIC","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",4,"LEU A  43;GLY A 205;ARG A   8;PHE A  24","None","0.68A","2wq5A-2vecA:undetectable","2wq5A-2vecA:20.25"],["5TE8_C_08JC602_1","CYTOCHROME P450 3A4","2vec","PIRIN-LIKE PROTEIN YHAK","Escherichia coli",4,"LEU A 202;ALA A 192;ILE A 164;LEU A 224","None","0.96A","5te8C-2vecA:undetectable","5te8C-2vecA:19.92"]]