SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vef'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 8 GLU A  45
GLY A  46
SER A 288
ASP A 263
 None
PO4  A1304 (-3.8A)
None
None
 0.81A 1m4iA-2vefA:
undetectable		 1m4iA-2vefA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  91
ASN A 110
ASP A 201
GLY A 233
SER A 235
 None
 0.70A 1q8jA-2vefA:
20.0		 1q8jA-2vefA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 4 ASP A 219
LEU A 214
LEU A 217
LEU A 215
 None
 1.39A 1u18A-2vefA:
undetectable		 1u18A-2vefA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_B_SAMB302_0
(YCGJ)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 GLY A 192
ALA A 188
ARG A 129
ALA A 126
HIS A 123
 None
 0.94A 2gluB-2vefA:
undetectable		 2gluB-2vefA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 8 ILE A  77
ARG A  81
LEU A 108
ASP A 107
GLY A 105
 None
 1.49A 2qqcH-2vefA:
undetectable
2qqcK-2vefA:
undetectable		 2qqcH-2vefA:
17.09
2qqcK-2vefA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  51
ASN A 110
ASP A 201
GLY A 233
SER A 235
 None
 1.25A 2ycjA-2vefA:
21.1		 2ycjA-2vefA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YCJ_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  91
ASN A 110
ASP A 201
GLY A 233
SER A 235
 None
 0.75A 2ycjA-2vefA:
21.1		 2ycjA-2vefA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  51
ASN A 110
VAL A 133
GLY A 233
SER A 235
 None
 1.20A 3k13B-2vefA:
18.8		 3k13B-2vefA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  91
ASN A 110
VAL A 133
GLY A 233
SER A 235
 None
 0.61A 3k13B-2vefA:
18.8		 3k13B-2vefA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASN A 110
ASP A 201
ARG A 262
 None
 0.58A 3k13C-2vefA:
18.8		 3k13C-2vefA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		6 / 12 ASP A  51
ASP A  91
ASN A 110
ASP A 201
GLY A 233
SER A 235
 None
 0.76A 4djeB-2vefA:
21.2		 4djeB-2vefA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 ASP A  51
ASP A  91
ASN A 110
GLY A 233
SER A 235
 None
 0.67A 4djfB-2vefA:
21.5		 4djfB-2vefA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A  91
LEU A 108
VAL A 124
 None
 0.66A 4jecB-2vefA:
undetectable		 4jecB-2vefA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 108
ASP A  91
ARG A 282
ILE A  15
 None
 1.23A 4mwrA-2vefA:
undetectable		 4mwrA-2vefA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 216
LEU A 208
PHE A 160
LEU A 176
ILE A 173
 None
 1.11A 4x1fA-2vefA:
undetectable		 4x1fA-2vefA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 216
LEU A 208
PHE A 160
LEU A 176
ILE A 173
 None
 1.12A 4x1gA-2vefA:
undetectable		 4x1gA-2vefA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  17
ASP A  91
ASN A 110
ASP A 201
 None
 0.74A 5vooA-2vefA:
6.1		 5vooA-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  17
ASP A  91
ASN A 110
ASP A 201
 None
 0.76A 5vooC-2vefA:
18.6		 5vooC-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 5 ASN A  17
ASP A  91
ASN A 110
ASP A 201
 None
 0.84A 5vooE-2vefA:
18.6		 5vooE-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A  91
ASN A 110
ASP A 201
 None
 0.27A 5vopA-2vefA:
18.6		 5vopA-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		3 / 3 ASP A  91
ASN A 110
ASP A 201
 None
 0.24A 5vopB-2vefA:
8.2		 5vopB-2vefA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		5 / 11 ALA A 130
ASP A  51
SER A  89
ILE A  80
ILE A  43
 None
 1.23A 5y80A-2vefA:
undetectable		 5y80A-2vefA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2vef DIHYDROPTEROATE
SYNTHASE
(Streptococcus
pneumoniae) 		4 / 6 SER A 235
GLY A 233
ILE A 112
PHE A 154
 None
 0.89A 6f8cA-2vefA:
undetectable		 6f8cA-2vefA:
14.43