SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ver'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		4 / 5 GLY A 136
LEU A 116
THR A 117
VAL A  28
 None
 1.04A 1ekjF-2verA:
undetectable
1ekjG-2verA:
undetectable		 1ekjF-2verA:
21.43
1ekjG-2verA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		3 / 3 ASN A  87
ALA A  76
ASN N  42
 None
 0.81A 1n4fA-2verA:
undetectable		 1n4fA-2verA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		4 / 5 TYR N  34
SER N  32
THR A  95
ASN A  74
 None
None
MTN  N1111 ( 4.7A)
None
 1.40A 1yvpA-2verN:
undetectable		 1yvpA-2verN:
12.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		4 / 6 GLY A  26
PRO A  27
GLY A  97
TYR A  99
 None
 0.87A 2jkjC-2verA:
11.0		 2jkjC-2verA:
96.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 2ver ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Homo
sapiens) 		5 / 12 LEU N  73
GLY N  63
ASN N  77
ILE N  79
ILE N  75
 None
 0.93A 2q64A-2verN:
undetectable		 2q64A-2verN:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		4 / 8 ASN N  97
ASN A  74
MET A  72
ILE A  96
 MTN  N1111 (-3.5A)
None
MTN  N1111 (-2.4A)
None
 1.35A 3kp6A-2verN:
undetectable
3kp6B-2verN:
undetectable		 3kp6A-2verN:
20.53
3kp6B-2verN:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 2ver AFIMBRIAL ADHESIN
AFA-III
ARCINOEMBRYONIC
ANTIGEN-RELATED CELL
ADHESION MOLECULE 5
(Escherichia
coli;
Homo
sapiens) 		5 / 12 THR A  95
GLY A   8
ALA N  55
GLY N  47
GLN N  53
 MTN  N1111 ( 4.7A)
None
None
None
None
 1.25A 3v3oA-2verA:
undetectable		 3v3oA-2verA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		3 / 3 TRP A  92
VAL A  89
TRP A  77
 None
 1.24A 3zq8A-2verA:
undetectable
3zq8B-2verA:
undetectable		 3zq8A-2verA:
9.48
3zq8B-2verA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		4 / 7 GLY A  94
THR A  95
ILE A  96
THR A 134
 None
MTN  N1111 ( 4.7A)
None
None
 0.86A 4acaC-2verA:
undetectable		 4acaC-2verA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		3 / 3 ASP A  80
VAL A  40
ASN A 125
 None
 0.77A 4lmnA-2verA:
undetectable		 4lmnA-2verA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		3 / 3 ASP A 101
ASN A  68
ASP A  80
 None
 0.84A 5vopA-2verA:
undetectable		 5vopA-2verA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2ver AFIMBRIAL ADHESIN
AFA-III
(Escherichia
coli) 		3 / 3 ALA A  44
PHE A 129
GLN A 127
 None
 0.82A 6eceA-2verA:
undetectable		 6eceA-2verA:
18.64