SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vf8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA8_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.83A 1a7yA-2vf8A:
undetectable		 1a7yA-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 762
PRO A 760
THR A 761
 None
 0.86A 1a7yB-2vf8A:
undetectable		 1a7yB-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_F_DVAF8_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.83A 1i3wF-2vf8A:
undetectable		 1i3wF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I3W_G_DVAG8_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.84A 1i3wG-2vf8A:
undetectable		 1i3wG-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 7 VAL A 320
ILE A 309
ARG A 351
LEU A 317
 None
 0.91A 1iepB-2vf8A:
undetectable		 1iepB-2vf8A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 ILE A  29
VAL A 404
LEU A  52
LEU A  91
ILE A  88
 None
 1.14A 1kqwA-2vf8A:
undetectable		 1kqwA-2vf8A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD2_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 762
PRO A 760
THR A 761
 None
 0.86A 1mnvD-2vf8A:
undetectable		 1mnvD-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MNV_D_DVAD8_0
(ACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.80A 1mnvD-2vf8A:
undetectable		 1mnvD-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 548
VAL A 528
LEU A 505
LEU A 539
LEU A 503
 None
 1.35A 1mx1B-2vf8A:
undetectable		 1mx1B-2vf8A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_A_DVAA8_0
(ACTINOMYCIN X2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.82A 1qfiA-2vf8A:
undetectable		 1qfiA-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 TRP A 449
VAL A  33
PRO A  34
 None
 0.96A 1rg1A-2vf8A:
undetectable		 1rg1A-2vf8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 TRP A 449
VAL A  33
PRO A  34
 None
 0.95A 1rh0A-2vf8A:
undetectable		 1rh0A-2vf8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF2_0
(7-AMINO-ACTINOMYCIN
D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 762
PRO A 760
THR A 761
 None
 0.86A 1unjF-2vf8A:
undetectable		 1unjF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_F_DVAF8_0
(7-AMINO-ACTINOMYCIN
D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.82A 1unjF-2vf8A:
undetectable		 1unjF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR8_0
(7-AMINO-ACTINOMYCIN
D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.83A 1unjR-2vf8A:
undetectable		 1unjR-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF2_0
(7-AMINOACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 762
PRO A 760
THR A 761
 None
 0.86A 1unmF-2vf8A:
undetectable		 1unmF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 THR A 761
THR A 762
PRO A 760
 None
 0.82A 1unmF-2vf8A:
undetectable		 1unmF-2vf8A:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 7 ALA A 710
ILE A 707
ASP A 610
PHE A 609
 None
 0.91A 1upfB-2vf8A:
undetectable		 1upfB-2vf8A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLY A 482
GLN A 483
HIS A 439
THR A  42
ILE A 444
 None
 1.49A 1z95A-2vf8A:
undetectable		 1z95A-2vf8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 4 VAL A 508
LEU A 522
ILE A 583
LEU A 580
 None
 1.05A 2byoA-2vf8A:
undetectable		 2byoA-2vf8A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 8 TYR A 721
ARG A 738
GLY A  43
GLY A  48
ALA A 457
 ADP  A1843 ( 4.8A)
None
None
ADP  A1843 (-3.2A)
None
 1.35A 2ej3C-2vf8A:
undetectable		 2ej3C-2vf8A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_C_SC2C1289_1
(FICOLIN-2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 6 SER A 381
SER A 532
LEU A 412
GLY A 411
 None
ADP  A1844 ( 4.4A)
None
None
 0.98A 2j2pA-2vf8A:
undetectable
2j2pC-2vf8A:
undetectable		 2j2pA-2vf8A:
13.68
2j2pC-2vf8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1289_1
(FICOLIN-2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 6 SER A 381
SER A 532
LEU A 412
GLY A 411
 None
ADP  A1844 ( 4.4A)
None
None
 1.00A 2j2pD-2vf8A:
undetectable
2j2pF-2vf8A:
undetectable		 2j2pD-2vf8A:
13.68
2j2pF-2vf8A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		6 / 12 LEU A 539
GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 None
ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 1.04A 2nxeA-2vf8A:
undetectable		 2nxeA-2vf8A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 1.02A 2nxeB-2vf8A:
undetectable		 2nxeB-2vf8A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ASP A 688
THR A 619
PRO A 620
 None
 0.56A 2pynB-2vf8A:
undetectable		 2pynB-2vf8A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ASP A 688
THR A 619
PRO A 620
 None
 0.54A 2q64B-2vf8A:
undetectable		 2q64B-2vf8A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ASP A 688
THR A 619
PRO A 620
 None
 0.56A 2qakB-2vf8A:
undetectable		 2qakB-2vf8A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 7 ILE A 464
LEU A 465
GLY A  43
GLY A  48
 None
None
None
ADP  A1843 (-3.2A)
 0.63A 2wd9A-2vf8A:
2.4		 2wd9A-2vf8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 8 ILE A 464
LEU A 465
GLY A  43
GLY A  48
 None
None
None
ADP  A1843 (-3.2A)
 0.64A 2wd9B-2vf8A:
2.3		 2wd9B-2vf8A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 SER A 537
ARG A 510
GLN A 542
 ADP  A1844 (-2.2A)
None
ADP  A1844 ( 4.1A)
 1.01A 2xnrA-2vf8A:
undetectable		 2xnrA-2vf8A:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 SER A 433
ALA A  37
LEU A  38
ALA A  96
VAL A 437
 None
 1.26A 2yvlC-2vf8A:
undetectable		 2yvlC-2vf8A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 0.98A 2zbpA-2vf8A:
undetectable		 2zbpA-2vf8A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 8 VAL A 802
GLY A 530
THR A 529
GLY A 535
 None
None
None
ADP  A1844 (-3.2A)
 0.68A 3aruA-2vf8A:
undetectable		 3aruA-2vf8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 8 VAL A 802
GLY A 530
THR A 529
GLY A 806
 None
 0.74A 3aruA-2vf8A:
undetectable		 3aruA-2vf8A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 0.98A 3cjtG-2vf8A:
undetectable		 3cjtG-2vf8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		6 / 12 LEU A 539
GLY A 535
GLY A 533
ASN A 511
LEU A 513
LEU A 516
 None
ADP  A1844 (-3.2A)
ADP  A1844 (-3.3A)
ADP  A1844 (-3.6A)
None
None
 1.04A 3cjtO-2vf8A:
undetectable		 3cjtO-2vf8A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 8 LEU A 450
ARG A 445
SER A  47
PRO A 766
 None
None
ADP  A1843 (-3.6A)
None
 1.00A 3hcrA-2vf8A:
undetectable		 3hcrA-2vf8A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 ALA A 788
MET A 525
GLU A 790
GLN A 794
ARG A 774
 None
 1.13A 3ia4A-2vf8A:
undetectable		 3ia4A-2vf8A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 4 PRO A 236
THR A 239
GLY A 253
THR A 254
 None
 1.04A 3ib1A-2vf8A:
undetectable		 3ib1A-2vf8A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ASP A 688
THR A 619
PRO A 620
 None
 0.53A 3tkgD-2vf8A:
undetectable		 3tkgD-2vf8A:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 8 ASP A  28
ILE A  29
GLY A  20
VAL A 453
ARG A 101
 None
None
None
None
ADP  A1843 (-3.1A)
 1.28A 4acbB-2vf8A:
undetectable
4acbC-2vf8A:
undetectable		 4acbB-2vf8A:
20.30
4acbC-2vf8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 8 ASP A 804
ILE A 805
GLY A 530
ARG A 588
 None
 0.85A 4acbB-2vf8A:
undetectable
4acbC-2vf8A:
undetectable		 4acbB-2vf8A:
20.30
4acbC-2vf8A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 PHE A  54
VAL A  16
ILE A  88
 None
 0.65A 4emaA-2vf8A:
undetectable		 4emaA-2vf8A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 366
LEU A 390
GLU A 418
LEU A 420
LEU A 424
 None
 1.15A 4wg0B-2vf8A:
undetectable
4wg0C-2vf8A:
undetectable
4wg0D-2vf8A:
undetectable		 4wg0B-2vf8A:
2.38
4wg0C-2vf8A:
2.38
4wg0D-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 366
LEU A 390
GLU A 418
LEU A 420
LEU A 424
 None
 1.13A 4wg0D-2vf8A:
undetectable
4wg0E-2vf8A:
undetectable
4wg0F-2vf8A:
undetectable		 4wg0D-2vf8A:
2.38
4wg0E-2vf8A:
2.38
4wg0F-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 366
LEU A 390
GLU A 418
LEU A 420
LEU A 424
 None
 1.12A 4wg0F-2vf8A:
undetectable
4wg0G-2vf8A:
undetectable
4wg0H-2vf8A:
undetectable		 4wg0F-2vf8A:
2.38
4wg0G-2vf8A:
2.38
4wg0H-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 424
GLU A 418
LEU A 420
LEU A 366
LEU A 390
 None
 1.18A 4wg0G-2vf8A:
undetectable
4wg0H-2vf8A:
undetectable
4wg0I-2vf8A:
undetectable		 4wg0G-2vf8A:
2.38
4wg0H-2vf8A:
2.38
4wg0I-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 366
LEU A 390
GLU A 418
LEU A 420
LEU A 424
 None
 1.14A 4wg0J-2vf8A:
undetectable
4wg0K-2vf8A:
undetectable
4wg0L-2vf8A:
undetectable		 4wg0J-2vf8A:
2.38
4wg0K-2vf8A:
2.38
4wg0L-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 LEU A 424
GLU A 418
LEU A 420
LEU A 366
LEU A 390
 None
 1.13A 4wg0I-2vf8A:
undetectable
4wg0J-2vf8A:
undetectable
4wg0K-2vf8A:
undetectable		 4wg0I-2vf8A:
2.38
4wg0J-2vf8A:
2.38
4wg0K-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_L_CHDL103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 7 LEU A 434
LEU A 405
LYS A 428
LEU A 427
 None
 0.82A 4wg0L-2vf8A:
undetectable
4wg0M-2vf8A:
undetectable		 4wg0L-2vf8A:
2.38
4wg0M-2vf8A:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_1
(ESTROGEN RECEPTOR)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 THR A 743
LEU A 745
ALA A 742
LEU A 772
GLY A 733
 None
 1.04A 4xi3C-2vf8A:
undetectable		 4xi3C-2vf8A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 11 ASP A 440
VAL A 769
ASP A 768
GLY A 411
GLY A 763
 None
 1.25A 4xp4A-2vf8A:
undetectable		 4xp4A-2vf8A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 6 ASP A 688
THR A 619
PRO A 620
VAL A 679
 None
 1.14A 4yoaA-2vf8A:
undetectable		 4yoaA-2vf8A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		6 / 12 GLU A  60
SER A  51
GLN A  23
VAL A  18
VAL A  31
VAL A  33
 None
ADP  A1843 (-3.3A)
None
None
None
None
 1.32A 5dpdA-2vf8A:
2.1		 5dpdA-2vf8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 THR A 310
LEU A 312
LEU A 123
GLY A 141
LEU A 295
 None
 1.08A 5gs4A-2vf8A:
undetectable		 5gs4A-2vf8A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ALA A 423
ASN A 426
LEU A 427
 None
 0.47A 5i1nC-2vf8A:
undetectable		 5i1nC-2vf8A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ALA A 423
ASN A 426
LEU A 427
 None
 0.38A 5i1oC-2vf8A:
undetectable		 5i1oC-2vf8A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 ALA A 423
ASN A 426
LEU A 427
 None
 0.46A 5i1pD-2vf8A:
undetectable		 5i1pD-2vf8A:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 SER A 534
THR A 538
GLY A 806
VAL A 817
LEU A 513
 ADP  A1844 (-3.9A)
ADP  A1844 (-3.2A)
None
None
None
 1.40A 5jo9A-2vf8A:
undetectable		 5jo9A-2vf8A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 VAL A 524
VAL A 528
ALA A 500
LEU A 505
LEU A 544
 None
 1.11A 5tudA-2vf8A:
2.2		 5tudA-2vf8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 4 GLY A 806
PRO A 807
VAL A 817
ARG A 815
 None
 1.24A 5uunA-2vf8A:
0.0
5uunB-2vf8A:
0.0		 5uunA-2vf8A:
17.79
5uunB-2vf8A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLN A 134
ILE A 309
LEU A 295
GLY A 149
GLY A 141
 None
 0.98A 5wyqB-2vf8A:
undetectable		 5wyqB-2vf8A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		4 / 6 LEU A  97
GLN A 393
LEU A 394
LEU A 427
 None
 1.21A 5yvnA-2vf8A:
undetectable		 5yvnA-2vf8A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 GLY A 733
THR A 762
LEU A 764
HIS A 765
THR A  42
 None
 1.20A 6e8qA-2vf8A:
undetectable		 6e8qA-2vf8A:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 LEU A 424
LEU A 434
SER A 381
LEU A 420
LEU A 368
 None
 0.97A 6ew0B-2vf8A:
undetectable		 6ew0B-2vf8A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 LEU A 424
LEU A 434
SER A 381
LEU A 420
LEU A 368
 None
 0.97A 6ew0D-2vf8A:
undetectable		 6ew0D-2vf8A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 LEU A 424
LEU A 434
SER A 381
LEU A 420
LEU A 368
 None
 0.97A 6ew0H-2vf8A:
undetectable		 6ew0H-2vf8A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 LEU A 424
LEU A 434
SER A 381
LEU A 420
LEU A 368
 None
 0.97A 6ew0I-2vf8A:
undetectable		 6ew0I-2vf8A:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 VAL A 694
LEU A 714
GLU A 696
ALA A 697
LEU A 608
 None
 1.09A 6f6iA-2vf8A:
undetectable
6f6iB-2vf8A:
undetectable		 6f6iA-2vf8A:
7.39
6f6iB-2vf8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		3 / 3 TRP A 208
ILE A 219
GLU A 214
 None
 0.61A 6hcxA-2vf8A:
undetectable		 6hcxA-2vf8A:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 2vf8 EXCINUCLEASE ABC
SUBUNIT A
(Deinococcus
radiodurans) 		5 / 12 LEU A 548
THR A 526
ILE A 787
ALA A 574
LEU A 803
 None
 1.23A 6ie8A-2vf8A:
undetectable		 6ie8A-2vf8A:
12.09