SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vfa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 12 ALA A  58
MET A 103
ALA A  72
VAL A 141
ALA A 169
 None
 1.20A 1sa1C-2vfaA:
undetectable
1sa1D-2vfaA:
undetectable		 1sa1C-2vfaA:
19.08
1sa1D-2vfaA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens;
Plasmodium
falciparum) 		4 / 8 LEU A 130
VAL A  71
LEU A 157
TYR A 161
 None
 1.10A 3v81A-2vfaA:
undetectable		 3v81A-2vfaA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens;
Plasmodium
falciparum) 		4 / 8 LEU A 130
VAL A  71
LEU A 157
TYR A 161
 None
 1.08A 3v81C-2vfaA:
undetectable		 3v81C-2vfaA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum;
Homo
sapiens) 		3 / 3 SER A 200
ASP A  60
ASP A  85
 None
 0.80A 4uckA-2vfaA:
2.3		 4uckA-2vfaA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Homo
sapiens;
Plasmodium
falciparum) 		5 / 10 VAL A  61
ASP A  60
LEU A  87
GLY A 188
LEU A 171
 None
 1.15A 5m5cE-2vfaA:
2.7		 5m5cE-2vfaA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2vfa HYPOXANTHINE-GUANINE
-XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE,
HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE
(Plasmodium
falciparum;
Homo
sapiens) 		5 / 12 ALA A  84
TYR A  80
ILE A 140
PHE A 107
ALA A  72
 None
 1.14A 5n5dB-2vfaA:
3.1		 5n5dB-2vfaA:
21.54