SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vfk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 12 GLU A 260
LEU A 171
ILE A 200
LEU A 164
ILE A 288
 None
 1.03A 1draA-2vfkA:
undetectable		 1draA-2vfkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 12 LEU A 171
ILE A 200
LEU A 164
ILE A 288
THR A  99
 None
 1.01A 1drbB-2vfkA:
undetectable		 1drbB-2vfkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 9 GLY A 289
ILE A 286
THR A 207
VAL A 160
ILE A 200
 None
 1.26A 2nnhB-2vfkA:
undetectable		 2nnhB-2vfkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 8 ILE A  98
ILE A 133
ILE A 265
ALA A 201
 None
 0.72A 2nniA-2vfkA:
undetectable		 2nniA-2vfkA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_K_ASDK1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 6 LEU A 171
ALA A 196
LEU A 198
ALA A 201
 None
 0.89A 2vcvK-2vfkA:
undetectable		 2vcvK-2vfkA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 6 LEU A 267
PHE A 208
LEU A 156
ASP A 151
 None
 0.99A 2wm3A-2vfkA:
undetectable		 2wm3A-2vfkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.23A 2xz5A-2vfkA:
undetectable
2xz5C-2vfkA:
undetectable		 2xz5A-2vfkA:
17.83
2xz5C-2vfkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.22A 2xz5C-2vfkA:
undetectable
2xz5D-2vfkA:
undetectable		 2xz5C-2vfkA:
17.83
2xz5D-2vfkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 12 GLU A 260
LEU A 171
ILE A 200
LEU A 164
THR A  99
 None
 1.27A 2zzaA-2vfkA:
undetectable		 2zzaA-2vfkA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 12 ALA A 204
LEU A  94
VAL A 160
ILE A  96
LEU A 262
 None
 1.13A 3fl9B-2vfkA:
undetectable		 3fl9B-2vfkA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 10 ALA A 204
LEU A  94
VAL A 160
ILE A  96
LEU A 262
 None
 1.07A 3fl9F-2vfkA:
undetectable		 3fl9F-2vfkA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 7 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.27A 3peoF-2vfkA:
0.0		 3peoF-2vfkA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 8 TYR A 280
CYH A 268
CYH A 282
TYR A 279
 None
 1.17A 4bqtC-2vfkA:
undetectable
4bqtD-2vfkA:
undetectable		 4bqtC-2vfkA:
17.83
4bqtD-2vfkA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 9 ALA A 204
THR A 203
ALA A 201
ILE A 213
ALA A 215
 None
 1.18A 4qvqK-2vfkA:
undetectable
4qvqL-2vfkA:
undetectable		 4qvqK-2vfkA:
20.55
4qvqL-2vfkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 9 ALA A 204
THR A 203
ALA A 201
ILE A 213
ALA A 215
 None
 1.18A 4qvqY-2vfkA:
undetectable
4qvqZ-2vfkA:
undetectable		 4qvqY-2vfkA:
20.55
4qvqZ-2vfkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		5 / 12 THR A 150
ALA A 152
GLU A 155
LEU A 156
LEU A 140
 None
 1.20A 4xi3A-2vfkA:
undetectable		 4xi3A-2vfkA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		3 / 3 THR A  99
PRO A  97
ASP A 266
 None
 0.79A 5l8dB-2vfkA:
undetectable		 5l8dB-2vfkA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		3 / 3 THR A  99
PRO A  97
ASP A 266
 None
 0.79A 5mwuB-2vfkA:
undetectable		 5mwuB-2vfkA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 4 LEU A 248
MET A 125
ILE A 253
LEU A 110
 None
 1.40A 5nfpA-2vfkA:
undetectable		 5nfpA-2vfkA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2vfk AKAP18 DELTA
(Homo
sapiens) 		4 / 4 ASP A 118
ILE A 244
PRO A 246
LEU A 248
 None
 1.27A 6mkeA-2vfkA:
undetectable		 6mkeA-2vfkA:
18.01