SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 250
LEU A  31
ALA A  75
ILE A  65
ILE A  35
None
1.10A 1crbA-2vfwA:
undetectable
1crbA-2vfwA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
4 / 5 VAL A 154
ASN A 153
VAL A 141
ILE A 111
None
0.86A 1z2bC-2vfwA:
undetectable
1z2bC-2vfwA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
4 / 7 SER A 226
LEU A 223
GLY A 159
THR A  87
None
1.10A 2bdmA-2vfwA:
undetectable
2bdmA-2vfwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
4 / 7 GLY A 157
ILE A 101
THR A 105
LEU A 126
None
0.88A 2xrhA-2vfwA:
undetectable
2xrhA-2vfwA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
6 / 12 LEU A 222
GLY A 124
GLY A 127
ALA A 155
LEU A 137
ILE A 129
None
1.32A 3ku1A-2vfwA:
3.1
3ku1A-2vfwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
6 / 12 LEU A 222
GLY A 124
GLY A 127
ALA A 155
LEU A 137
ILE A 129
None
1.33A 3ku1C-2vfwA:
3.2
3ku1C-2vfwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
6 / 12 LEU A 222
GLY A 124
GLY A 127
ALA A 155
LEU A 137
ILE A 129
None
1.33A 3ku1H-2vfwA:
3.0
3ku1H-2vfwA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
5 / 12 GLU A  88
ILE A 164
LEU A 198
GLY A 159
SER A  86
None
1.48A 4djfB-2vfwA:
undetectable
4djfB-2vfwA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
6 / 12 CYH A  72
LEU A  69
THR A 212
ILE A  35
ALA A  80
ILE A 210
None
1.42A 4o2bD-2vfwA:
undetectable
4o2bD-2vfwA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
5 / 12 LEU A 250
LEU A  31
ALA A  75
ILE A  65
ILE A  35
None
1.15A 5h8tA-2vfwA:
undetectable
5h8tA-2vfwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
6 / 12 CYH A  72
LEU A  69
THR A 212
ILE A  35
ALA A  80
ILE A 210
None
1.46A 5xiwB-2vfwA:
undetectable
5xiwB-2vfwA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis)
5 / 12 THR A  81
VAL A  82
VAL A  37
VAL A 141
GLU A 142
None
1.24A 6bzoC-2vfwA:
undetectable
6bzoC-2vfwA:
11.25