SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vg2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 196
GLY A 197
ASN A 253
ALA A 204
LEU A 231
 None
 0.96A 1bx4A-2vg2A:
undetectable		 1bx4A-2vg2A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_1
(NEURAMINIDASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 127
ARG A 250
ARG A  89
 DPO  A1297 ( 3.0A)
IPE  A1298 (-3.7A)
DPO  A1297 (-2.7A)
 1.02A 1l7fA-2vg2A:
undetectable		 1l7fA-2vg2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_1
(NEURAMINIDASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 127
ARG A 250
ARG A  89
 DPO  A1297 ( 3.0A)
IPE  A1298 (-3.7A)
DPO  A1297 (-2.7A)
 1.03A 1l7hA-2vg2A:
undetectable		 1l7hA-2vg2A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_A_CLWA906_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  68
VAL A 239
TYR A 286
GLU A 263
 None
 1.44A 1m8dA-2vg2A:
0.0		 1m8dA-2vg2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  68
VAL A 239
TYR A 286
GLU A 263
 None
 1.47A 1m8dB-2vg2A:
0.0		 1m8dB-2vg2A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_A_CLWA906_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  68
VAL A 239
TYR A 286
GLU A 263
 None
 1.36A 1m9jA-2vg2A:
0.0		 1m9jA-2vg2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A  68
VAL A 239
TYR A 286
GLU A 263
 None
 1.40A 1m9jB-2vg2A:
0.0		 1m9jB-2vg2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.14A 1p7lC-2vg2A:
undetectable		 1p7lC-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.13A 1p7lD-2vg2A:
undetectable		 1p7lD-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.10A 1rg9A-2vg2A:
undetectable		 1rg9A-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.10A 1rg9B-2vg2A:
undetectable		 1rg9B-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.14A 1rg9C-2vg2A:
undetectable		 1rg9C-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 8 HIS A  53
PRO A  27
ASP A 102
THR A 245
 None
 1.13A 1rg9D-2vg2A:
undetectable		 1rg9D-2vg2A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  27
HIS A  53
LEU A 279
ILE A 103
 None
 1.09A 1sbrA-2vg2A:
undetectable
1sbrB-2vg2A:
undetectable		 1sbrA-2vg2A:
21.40
1sbrB-2vg2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 153
GLY A 154
LEU A 150
ILE A 189
ILE A 108
 None
 1.11A 2f8dB-2vg2A:
undetectable		 2f8dB-2vg2A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A  26
ALA A  98
THR A 149
ARG A 145
LEU A  39
 None
GOL  A1302 (-3.1A)
None
None
None
 1.36A 2rctA-2vg2A:
undetectable		 2rctA-2vg2A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 ARG A 244
PHE A 254
SER A 252
VAL A 170
LEU A 174
 IPE  A1298 (-3.4A)
None
IPE  A1298 (-2.5A)
None
None
 1.23A 3a9eB-2vg2A:
undetectable		 3a9eB-2vg2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 12 PRO A  50
GLY A 111
ILE A  62
ARG A 276
LEU A 110
 None
 1.27A 3iv6C-2vg2A:
undetectable		 3iv6C-2vg2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 THR A  90
GLY A  92
ARG A 145
LEU A  87
 None
 0.99A 4acbC-2vg2A:
undetectable		 4acbC-2vg2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 7 TRP A 159
GLY A 196
GLY A 197
GLU A 123
 None
 1.11A 4fgkB-2vg2A:
undetectable		 4fgkB-2vg2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 10 CYH A 283
LEU A 279
LEU A 110
ALA A 107
LEU A 115
 None
 1.21A 4p65A-2vg2A:
undetectable
4p65B-2vg2A:
undetectable
4p65F-2vg2A:
undetectable
4p65H-2vg2A:
undetectable		 4p65A-2vg2A:
10.00
4p65B-2vg2A:
9.33
4p65F-2vg2A:
9.33
4p65H-2vg2A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 115
CYH A 283
LEU A 279
LEU A 110
ALA A 107
 None
 1.14A 4p65B-2vg2A:
undetectable
4p65D-2vg2A:
undetectable
4p65G-2vg2A:
undetectable
4p65H-2vg2A:
undetectable		 4p65B-2vg2A:
9.33
4p65D-2vg2A:
9.33
4p65G-2vg2A:
10.00
4p65H-2vg2A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQD_A_GAIA1005_0
(THIOSULFATE
DEHYDROGENASE)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A  89
ARG A 127
GLY A  77
ARG A  80
 DPO  A1297 (-2.7A)
DPO  A1297 ( 3.0A)
DPO  A1297 (-3.0A)
DPO  A1297 (-3.8A)
 0.90A 4wqdA-2vg2A:
0.0		 4wqdA-2vg2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 173
ARG A 147
ALA A 175
LEU A 174
 None
 1.11A 5phhA-2vg2A:
undetectable		 5phhA-2vg2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Mycobacterium
tuberculosis) 		4 / 6 PRO A  20
TYR A  44
PRO A  40
LEU A  39
 None
 0.93A 5tl8A-2vg2A:
undetectable		 5tl8A-2vg2A:
21.23