SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vg9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 6 TYR A  96
GLY A  62
PHE A  61
SER A  63
 None
 1.31A 2a3cA-2vg9A:
undetectable		 2a3cA-2vg9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 6 TYR A  96
GLY A  62
PHE A  61
SER A  63
 None
 1.36A 2a3cB-2vg9A:
undetectable		 2a3cB-2vg9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 8 TYR A 137
ARG A 163
GLU A 116
VAL A 130
 None
 1.10A 2fl5E-2vg9A:
undetectable
2fl5F-2vg9A:
undetectable		 2fl5E-2vg9A:
19.41
2fl5F-2vg9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		5 / 12 LEU A 191
LEU A  75
GLY A  74
VAL A  95
ALA A 195
 None
 1.16A 2kceB-2vg9A:
undetectable		 2kceB-2vg9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 6 THR A 131
ASP A 133
THR A 173
ASP A  76
 None
 1.18A 2okcB-2vg9A:
undetectable		 2okcB-2vg9A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SM2_A_478A126_2
(GAG-PRO-POL
POLYPROTEIN)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		5 / 11 VAL A 214
GLY A  97
LEU A  59
TYR A  77
LEU A  75
 None
 0.95A 3sm2B-2vg9A:
undetectable		 3sm2B-2vg9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 5 GLY A  89
ASP A 120
GLU A 199
VAL A 162
 None
CD  A1218 (-2.1A)
None
None
 1.06A 4nkvD-2vg9A:
undetectable		 4nkvD-2vg9A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		3 / 3 MET A 129
GLN A 141
TYR A 159
 None
 0.98A 4udcA-2vg9A:
undetectable		 4udcA-2vg9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 7 ASN A 190
LYS A  66
LEU A  59
PHE A  19
 None
 1.06A 4yv5A-2vg9A:
undetectable		 4yv5A-2vg9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 7 ASN A 190
LYS A  66
LEU A  59
PHE A  19
 None
 1.12A 4yv5B-2vg9A:
undetectable		 4yv5B-2vg9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		3 / 4 ARG A  56
GLY A  58
GLU A 193
 None
 0.58A 4z2dB-2vg9A:
undetectable
4z2dC-2vg9A:
undetectable		 4z2dB-2vg9A:
17.59
4z2dC-2vg9A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 6 ALA A  79
ARG A  56
GLY A  58
GLU A 193
 None
 0.99A 5btgA-2vg9A:
undetectable
5btgB-2vg9A:
undetectable
5btgC-2vg9A:
undetectable		 5btgA-2vg9A:
18.52
5btgB-2vg9A:
22.99
5btgC-2vg9A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 7 ALA A  47
GLY A  89
SER A  91
GLY A 200
 None
 0.88A 5e26A-2vg9A:
undetectable
5e26B-2vg9A:
undetectable		 5e26A-2vg9A:
19.41
5e26B-2vg9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 7 GLY A  89
SER A  91
GLY A 200
ALA A  47
 None
 0.85A 5e26C-2vg9A:
undetectable
5e26D-2vg9A:
undetectable		 5e26C-2vg9A:
19.41
5e26D-2vg9A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		4 / 7 ILE A 149
TYR A  96
ARG A  56
GLN A  11
 None
 1.29A 5kkzK-2vg9A:
undetectable
5kkzQ-2vg9A:
undetectable		 5kkzK-2vg9A:
18.06
5kkzQ-2vg9A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A
(Neocallimastix
patriciarum) 		5 / 12 GLY A 200
ASN A  90
GLU A 199
ASN A 197
CYH A  94
 None
ACT  A1220 (-3.9A)
None
None
None
 1.28A 5xxgA-2vg9A:
undetectable		 5xxgA-2vg9A:
17.62