SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vge'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_1
(HIV-1 PROTEASE)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		6 / 10 LEU A 640
ALA A 635
VAL A 676
ILE A 668
GLY A 670
ILE A 675
 None
 1.45A 1hsgA-2vgeA:
undetectable		 1hsgA-2vgeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		5 / 12 TYR A 747
ALA A 762
GLY A 716
GLY A 816
LEU A 697
 None
 1.06A 1x1aA-2vgeA:
undetectable		 1x1aA-2vgeA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		6 / 12 LEU A 640
ALA A 635
VAL A 676
ILE A 668
GLY A 670
ILE A 675
 None
 1.45A 2o4lB-2vgeA:
undetectable		 2o4lB-2vgeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		6 / 12 LEU A 640
ALA A 635
VAL A 676
ILE A 668
GLY A 670
ILE A 675
 None
 1.43A 3tl9B-2vgeA:
undetectable		 3tl9B-2vgeA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		4 / 5 PRO A 696
HIS A 715
LEU A 640
TYR A 673
 None
 1.46A 5igjA-2vgeA:
undetectable		 5igjA-2vgeA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		5 / 12 ILE A 661
GLY A 660
LEU A 712
ASN A 685
LEU A 664
 None
 0.79A 5nfjA-2vgeA:
undetectable		 5nfjA-2vgeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		4 / 7 PHE A 815
ALA A 717
GLY A 816
ASN A 685
 None
 0.81A 5ybbB-2vgeA:
undetectable		 5ybbB-2vgeA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 2vge RELA-ASSOCIATED
INHIBITOR
(Homo
sapiens) 		6 / 12 LEU A 640
ALA A 635
VAL A 676
ILE A 668
GLY A 670
ILE A 675
 None
 1.47A 6dilB-2vgeA:
undetectable		 6dilB-2vgeA:
16.06