SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 8 PHE A 323
GLY A 319
ARG A 322
VAL A 294
 None
 0.91A 1gsfC-2vgiA:
undetectable		 1gsfC-2vgiA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 9 ASP A 331
VAL A 283
GLY A 305
VAL A 294
ILE A 310
 None
 1.12A 1hpvB-2vgiA:
undetectable		 1hpvB-2vgiA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 4 LEU A 340
VAL A 335
CYH A 369
ALA A 394
 None
 1.04A 1mz9E-2vgiA:
undetectable		 1mz9E-2vgiA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 4 LEU A 340
VAL A 335
CYH A 369
ALA A 399
 None
 1.20A 1mz9E-2vgiA:
undetectable		 1mz9E-2vgiA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 12 LEU A 546
GLY A 549
ILE A 472
VAL A 570
LEU A 571
 None
 0.91A 1uakA-2vgiA:
undetectable		 1uakA-2vgiA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 8 SER A 225
ARG A 216
GLN A 229
ASN A 242
 None
 1.20A 1zzuA-2vgiA:
1.2		 1zzuA-2vgiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 6 PRO A  96
HIS A 121
ASP A 271
TYR A 126
 None
 1.34A 2lh8A-2vgiA:
undetectable		 2lh8A-2vgiA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 THR A 164
ASP A 339
SER A 286
 None
MN  A1577 ( 2.6A)
K  A1576 (-3.1A)
 0.81A 2nxeB-2vgiA:
5.5		 2nxeB-2vgiA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 ALA A 346
TYR A 218
ILE A 344
ILE A 342
 None
 1.07A 2zm7A-2vgiA:
undetectable		 2zm7A-2vgiA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 9 ALA A 346
TYR A 218
ILE A 344
GLY A 341
ILE A 342
 None
 1.06A 2zm9A-2vgiA:
0.0		 2zm9A-2vgiA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 VAL A 101
LYS A 105
ILE A 108
GLY A 111
 None
 0.88A 3bjwB-2vgiA:
undetectable		 3bjwB-2vgiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 VAL A 101
LYS A 105
ILE A 108
GLY A 111
 None
 0.88A 3bjwF-2vgiA:
undetectable		 3bjwF-2vgiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 VAL A 101
LYS A 105
ILE A 108
GLY A 111
 None
 0.90A 3bjwH-2vgiA:
undetectable		 3bjwH-2vgiA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 THR A  88
SER A  87
ARG A 510
 None
 0.74A 3phnA-2vgiA:
undetectable		 3phnA-2vgiA:
11.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		7 / 10 THR A  93
ARG A 116
ASN A 118
HIS A 121
GLY A 406
ALA A 409
LYS A 410
 None
PGA  A1575 (-3.7A)
K  A1576 (-4.0A)
None
None
None
None
 0.77A 3pp7B-2vgiA:
58.5		 3pp7B-2vgiA:
47.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		9 / 10 THR A  93
PRO A  96
ARG A 116
ASN A 118
HIS A 121
GLY A 122
TYR A 126
GLY A 406
ALA A 409
 None
None
PGA  A1575 (-3.7A)
K  A1576 (-4.0A)
None
None
None
None
None
 0.54A 3pp7B-2vgiA:
58.5		 3pp7B-2vgiA:
47.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 ARG A  99
GLU A 129
ASN A 133
 None
 0.76A 4imaD-2vgiA:
62.6		 4imaD-2vgiA:
99.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 ARG A  99
GLU A 129
ASN A 133
 None
 0.80A 4ip7D-2vgiA:
57.1		 4ip7D-2vgiA:
99.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 LEU A  61
PRO A  62
ARG A 426
 None
 0.74A 4klrB-2vgiA:
2.2		 4klrB-2vgiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 6 ASP A 339
GLU A 161
ASN A 118
ARG A 116
 MN  A1577 ( 2.6A)
K  A1576 ( 4.8A)
K  A1576 (-4.0A)
PGA  A1575 (-3.7A)
 1.16A 4ntxA-2vgiA:
undetectable
4ntxC-2vgiA:
undetectable		 4ntxA-2vgiA:
21.55
4ntxC-2vgiA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 SER A 389
ASP A 390
GLN A 353
 None
 0.92A 4oltA-2vgiA:
undetectable
4oltB-2vgiA:
undetectable		 4oltA-2vgiA:
20.20
4oltB-2vgiA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 12 ALA A 481
GLN A 482
GLY A 511
CYH A 509
ALA A  85
 None
 1.09A 4pclA-2vgiA:
4.3		 4pclA-2vgiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 8 LEU A 236
VAL A 185
ILE A 162
LEU A 254
 None
 0.86A 4qrcA-2vgiA:
undetectable		 4qrcA-2vgiA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 12 ARG A 216
GLY A 256
GLU A 347
ALA A 346
TYR A 218
 None
 1.23A 4r29B-2vgiA:
undetectable		 4r29B-2vgiA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		5 / 12 ALA A 370
SER A 376
THR A 384
GLU A 407
SER A 405
 PGA  A1575 ( 4.9A)
None
None
None
PGA  A1575 ( 4.9A)
 1.20A 5hfjE-2vgiA:
undetectable		 5hfjE-2vgiA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 5 ARG A 518
PRO A 145
GLY A 143
TYR A 148
 None
 0.91A 5x80A-2vgiA:
undetectable
5x80B-2vgiA:
undetectable		 5x80A-2vgiA:
16.63
5x80B-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 6 PRO A 145
GLY A 143
TYR A 148
ARG A 518
 None
 0.91A 5x80A-2vgiA:
undetectable
5x80B-2vgiA:
undetectable		 5x80A-2vgiA:
16.63
5x80B-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 ARG A 518
PRO A 145
GLY A 143
TYR A 148
 None
 0.94A 5x80C-2vgiA:
undetectable
5x80D-2vgiA:
undetectable		 5x80C-2vgiA:
16.63
5x80D-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 5 PRO A 145
GLY A 143
TYR A 148
ARG A 518
 None
 0.88A 5x80C-2vgiA:
undetectable
5x80D-2vgiA:
undetectable		 5x80C-2vgiA:
16.63
5x80D-2vgiA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		3 / 3 LYS A 365
PRO A 366
LYS A 309
 None
 1.27A 5y9yA-2vgiA:
undetectable		 5y9yA-2vgiA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2vgi PYRUVATE KINASE
ISOZYMES R/L
(Homo
sapiens) 		4 / 7 GLN A 168
GLY A 195
VAL A 185
SER A 248
 None
 0.92A 6hu9S-2vgiA:
undetectable
6hu9q-2vgiA:
undetectable		 6hu9S-2vgiA:
10.65
6hu9q-2vgiA:
11.74