SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vhf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		3 / 3 ASP A 604
HIS A 871
ASP A 889
 None
 0.87A 1nw5A-2vhfA:
undetectable		 1nw5A-2vhfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		5 / 10 TYR A 878
PHE A 875
ALA A 612
ASP A 889
VAL A 873
 None
 1.35A 3ay0A-2vhfA:
undetectable		 3ay0A-2vhfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		4 / 7 LEU A 752
TYR A 715
LEU A 734
TYR A 947
 None
 1.02A 4b3qA-2vhfA:
undetectable		 4b3qA-2vhfA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		3 / 3 LEU A 733
GLU A 735
SER A 737
 None
 0.78A 4ccqA-2vhfA:
undetectable		 4ccqA-2vhfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		5 / 11 LEU A 662
ILE A 659
LEU A 607
LEU A 686
ILE A 688
 None
 1.15A 4dm8A-2vhfA:
undetectable		 4dm8A-2vhfA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		4 / 7 ASP A 889
SER A 605
HIS A 871
SER A 890
 None
 1.24A 4k7gB-2vhfA:
undetectable		 4k7gB-2vhfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		5 / 12 CYH A 609
LEU A 610
LEU A 865
ALA A 874
ILE A 594
 None
 1.09A 4x1kD-2vhfA:
undetectable		 4x1kD-2vhfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		4 / 6 VAL A 696
LEU A 752
ILE A 777
PHE A 745
 None
 0.83A 5jw1A-2vhfA:
undetectable		 5jw1A-2vhfA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD
(Homo
sapiens) 		4 / 6 TYR A 955
VAL A 616
GLU A 860
ALA A 884
 None
 1.16A 6djzB-2vhfA:
undetectable		 6djzB-2vhfA:
20.16