SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vhh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 8 ILE A 163
LEU A 155
GLU A 110
ALA A 108
VAL A 116
 None
 1.19A 1a29A-2vhhA:
undetectable		 1a29A-2vhhA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 10 ILE A 105
ALA A 108
ALA A 109
ASN A 160
ILE A 185
 None
 1.08A 2aclC-2vhhA:
undetectable		 2aclC-2vhhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 11 ILE A 105
ALA A 108
ALA A 109
ASN A 160
ILE A 185
 None
 1.10A 2aclE-2vhhA:
undetectable		 2aclE-2vhhA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 8 TYR A 319
GLY A  31
GLY A 325
ALA A 321
ALA A 322
 None
 1.46A 2ej3C-2vhhA:
undetectable		 2ej3C-2vhhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		3 / 3 SER A 317
ASP A  54
ASP A 334
 None
 0.75A 2plwA-2vhhA:
2.2		 2plwA-2vhhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 LEU A 268
GLU A 272
SER A 265
THR A 260
 None
 1.12A 3dzgB-2vhhA:
undetectable		 3dzgB-2vhhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3006_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 6 ASN A 187
MET A 161
ILE A 115
GLU A 225
 None
 1.46A 3kp6A-2vhhA:
undetectable
3kp6B-2vhhA:
undetectable		 3kp6A-2vhhA:
15.66
3kp6B-2vhhA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		3 / 3 ARG A  59
LEU A  38
THR A 328
 None
 0.89A 3oxcA-2vhhA:
undetectable		 3oxcA-2vhhA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 9 LEU A 155
TYR A 159
ILE A 164
MET A 104
VAL A 340
 None
 1.44A 3oxzA-2vhhA:
undetectable		 3oxzA-2vhhA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 6 LEU A 268
GLU A 272
SER A 265
THR A 260
 None
 1.12A 3ropA-2vhhA:
undetectable		 3ropA-2vhhA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 VAL A 116
ILE A 105
THR A 148
THR A 149
 None
 1.00A 3tneB-2vhhA:
undetectable		 3tneB-2vhhA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_A_NCAA1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 THR A 284
TRP A 243
ASN A 275
TYR A 319
 None
 1.28A 4a3uA-2vhhA:
2.7		 4a3uA-2vhhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_NCAB1359_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 THR A 284
TRP A 243
ASN A 275
TYR A 319
 None
 1.26A 4a3uB-2vhhA:
2.1		 4a3uB-2vhhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 6 GLY A 227
ASN A 187
GLU A 252
ILE A 253
 None
 0.95A 4fglD-2vhhA:
undetectable		 4fglD-2vhhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_K_KANK301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 8 ASP A  54
ASP A  35
ASN A   8
GLU A  14
 None
 1.15A 4gkhC-2vhhA:
undetectable
4gkhK-2vhhA:
undetectable		 4gkhC-2vhhA:
20.59
4gkhK-2vhhA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 ILE A  82
THR A  86
VAL A 101
PHE A 139
 None
 1.13A 4iarA-2vhhA:
undetectable		 4iarA-2vhhA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 6 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.05A 4mi4A-2vhhA:
undetectable		 4mi4A-2vhhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.07A 4mi4B-2vhhA:
undetectable
4mi4C-2vhhA:
undetectable		 4mi4B-2vhhA:
18.47
4mi4C-2vhhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 7 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.09A 4mi4A-2vhhA:
undetectable
4mi4C-2vhhA:
undetectable		 4mi4A-2vhhA:
18.47
4mi4C-2vhhA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 8 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.04A 4mj8A-2vhhA:
undetectable
4mj8C-2vhhA:
undetectable		 4mj8A-2vhhA:
17.49
4mj8C-2vhhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 8 ASN A 145
GLU A 173
GLU A 169
GLU A 144
 None
 1.07A 4mj8B-2vhhA:
undetectable
4mj8C-2vhhA:
undetectable		 4mj8B-2vhhA:
17.49
4mj8C-2vhhA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 5 SER A 317
GLY A 316
ARG A 333
GLU A 266
 None
 1.22A 4r82A-2vhhA:
undetectable
4r82B-2vhhA:
undetectable		 4r82A-2vhhA:
17.96
4r82B-2vhhA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 9 CYH A 113
ALA A  44
LEU A 338
ILE A 105
 None
 0.94A 4xtaA-2vhhA:
undetectable		 4xtaA-2vhhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 12 LEU A 229
ALA A 251
LEU A 345
ARG A  71
LEU A 343
 None
 1.01A 5toaA-2vhhA:
undetectable		 5toaA-2vhhA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		5 / 10 LYS A  56
ASP A  54
SER A 330
ASN A  10
ASN A   8
 None
 1.18A 5x6yB-2vhhA:
undetectable		 5x6yB-2vhhA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2vhh CG3027-PA
(Drosophila
melanogaster) 		4 / 8 ARG A 196
HIS A 195
GLU A 169
ASP A 171
 None
 0.99A 6mn4D-2vhhA:
undetectable		 6mn4D-2vhhA:
19.15