SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vhl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 HIS A  63
HIS A  65
ASP A  71
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1397 (-3.3A)
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.85A 1a4lA-2vhlA:
14.5		 1a4lA-2vhlA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 HIS A  63
HIS A  65
ASP A  71
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1397 (-3.3A)
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.81A 1a4lC-2vhlA:
14.5		 1a4lC-2vhlA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 9 LEU A 379
ILE A 381
VAL A  24
GLY A  25
LEU A  55
 None
 1.14A 1e7aB-2vhlA:
undetectable		 1e7aB-2vhlA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 5 HIS A  63
HIS A 202
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1398 ( 3.3A)
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.66A 1e9yB-2vhlA:
19.1		 1e9yB-2vhlA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 4 ILE A 107
LEU A 187
VAL A 175
ILE A 172
 None
 0.73A 1fm6D-2vhlA:
undetectable		 1fm6D-2vhlA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 6 HIS A  63
HIS A  65
HIS A 202
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1397 (-3.3A)
FE  A1398 ( 3.3A)
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.69A 1fweC-2vhlA:
19.9		 1fweC-2vhlA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 GLY A  58
GLY A  91
ALA A 128
ASP A 365
SER A 344
 None
 1.11A 1ri4A-2vhlA:
undetectable		 1ri4A-2vhlA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		3 / 3 LYS A 320
ILE A 253
THR A 343
 None
 0.74A 1rx3A-2vhlA:
undetectable		 1rx3A-2vhlA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 SER A 282
ILE A 277
ILE A 279
THR A  98
 None
 0.93A 1sbrA-2vhlA:
undetectable		 1sbrA-2vhlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 SER A 282
ILE A 277
ILE A 279
THR A  98
 None
 0.92A 1sbrB-2vhlA:
undetectable		 1sbrB-2vhlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.93A 1v7zA-2vhlA:
undetectable		 1v7zA-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.93A 1v7zB-2vhlA:
undetectable		 1v7zB-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 8 GLU A 136
HIS A 134
HIS A 202
HIS A  63
GLU A 251
 FE  A1397 ( 2.6A)
None
FE  A1398 ( 3.3A)
FE  A1397 (-3.3A)
None
 1.16A 1v7zB-2vhlA:
undetectable		 1v7zB-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.93A 1v7zC-2vhlA:
undetectable		 1v7zC-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 8 GLU A 136
HIS A 134
HIS A 202
HIS A  63
GLU A 251
 FE  A1397 ( 2.6A)
None
FE  A1398 ( 3.3A)
FE  A1397 (-3.3A)
None
 1.15A 1v7zC-2vhlA:
undetectable		 1v7zC-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.94A 1v7zD-2vhlA:
undetectable		 1v7zD-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.94A 1v7zE-2vhlA:
undetectable		 1v7zE-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.93A 1v7zF-2vhlA:
undetectable		 1v7zF-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 8 GLU A 136
HIS A 134
HIS A 202
HIS A  63
GLU A 251
 FE  A1397 ( 2.6A)
None
FE  A1398 ( 3.3A)
FE  A1397 (-3.3A)
None
 1.17A 1v7zF-2vhlA:
undetectable		 1v7zF-2vhlA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 6 LEU A  87
TYR A  68
ILE A  64
GLY A 287
 None
 0.93A 2du8A-2vhlA:
undetectable		 2du8A-2vhlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 4 SER A 282
GLY A  67
HIS A 327
ASP A 374
 None
 1.29A 2oxtC-2vhlA:
undetectable		 2oxtC-2vhlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 HIS A  65
ASP A  71
ILE A 100
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
None
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 1.23A 2pgfA-2vhlA:
15.3		 2pgfA-2vhlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		6 / 12 HIS A  63
HIS A  65
ASP A  71
ILE A 100
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1397 (-3.3A)
None
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 1.28A 2pgrA-2vhlA:
15.3		 2pgrA-2vhlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 10 THR A 176
GLY A 137
HIS A  65
THR A 222
HIS A 223
 None
None
FE  A1397 (-3.3A)
None
FE  A1398 (-3.3A)
 1.19A 2y7wB-2vhlA:
undetectable		 2y7wB-2vhlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 THR A  92
LYS A 357
GLU A 129
SER A  84
 None
 0.95A 2zw9A-2vhlA:
undetectable		 2zw9A-2vhlA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 PRO A  39
LEU A   6
ILE A  31
ALA A 366
LEU A  55
 None
 1.07A 3a50D-2vhlA:
undetectable		 3a50D-2vhlA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.92A 3a6jA-2vhlA:
undetectable		 3a6jA-2vhlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.90A 3a6jB-2vhlA:
undetectable		 3a6jB-2vhlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.91A 3a6jC-2vhlA:
undetectable		 3a6jC-2vhlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.92A 3a6jE-2vhlA:
undetectable		 3a6jE-2vhlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLU A 136
HIS A  65
ASP A 281
HIS A 223
 FE  A1397 ( 2.6A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.7A)
FE  A1398 (-3.3A)
 0.90A 3a6jF-2vhlA:
undetectable		 3a6jF-2vhlA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 6 THR A 332
ILE A 342
SER A 273
LEU A 276
 None
 0.92A 3deuB-2vhlA:
undetectable		 3deuB-2vhlA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 6 LEU A 319
GLU A 323
ASN A 322
SER A 317
 None
 1.47A 3i9jB-2vhlA:
undetectable		 3i9jB-2vhlA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 LEU A 276
LEU A 278
SER A 344
ASN A 346
 None
 0.95A 3lm8A-2vhlA:
undetectable
3lm8C-2vhlA:
undetectable		 3lm8A-2vhlA:
20.25
3lm8C-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 LEU A 276
LEU A 278
SER A 344
ASN A 346
 None
 0.94A 3lm8B-2vhlA:
1.9
3lm8D-2vhlA:
undetectable		 3lm8B-2vhlA:
20.25
3lm8D-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 LEU A 276
LEU A 278
SER A 344
ASN A 346
 None
 1.02A 3lm8B-2vhlA:
undetectable
3lm8D-2vhlA:
undetectable		 3lm8B-2vhlA:
20.25
3lm8D-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 6 ALA A 110
ILE A 107
LEU A 111
ALA A  97
 None
 0.90A 3r9sA-2vhlA:
1.0		 3r9sA-2vhlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 THR A 250
HIS A  63
ILE A 279
ILE A 197
HIS A 134
 None
FE  A1397 (-3.3A)
None
None
None
 1.23A 3sp9A-2vhlA:
undetectable		 3sp9A-2vhlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 LEU A 276
ALA A 270
GLY A 240
ILE A 239
 None
 0.81A 3spkB-2vhlA:
undetectable		 3spkB-2vhlA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 VAL A 249
HIS A 220
ILE A 353
ALA A 347
ALA A 348
 None
 0.88A 3sufD-2vhlA:
undetectable		 3sufD-2vhlA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		3 / 3 LYS A 118
ARG A 356
LEU A 131
 None
 1.11A 3v4tE-2vhlA:
undetectable		 3v4tE-2vhlA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 8 GLY A 363
ASP A 365
ASP A 367
THR A  14
 None
 0.72A 4eyrB-2vhlA:
undetectable		 4eyrB-2vhlA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		3 / 3 LYS A 320
ILE A 253
THR A 343
 None
 0.73A 4gh8A-2vhlA:
undetectable		 4gh8A-2vhlA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 5 HIS A  63
HIS A 202
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1398 ( 3.3A)
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.68A 4h9mA-2vhlA:
21.3		 4h9mA-2vhlA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 10 LEU A 131
LEU A  96
ILE A 353
THR A 176
HIS A 220
 None
 1.10A 4mk4A-2vhlA:
undetectable		 4mk4A-2vhlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 9 ALA A 198
ALA A 218
LEU A 210
SER A 156
LEU A 187
 None
 1.17A 4or0A-2vhlA:
undetectable		 4or0A-2vhlA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 6 PHE A 295
HIS A 223
HIS A  63
GLU A 136
 None
FE  A1398 (-3.3A)
FE  A1397 (-3.3A)
FE  A1397 ( 2.6A)
 1.11A 4pahA-2vhlA:
undetectable		 4pahA-2vhlA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 ALA A 347
GLY A 352
ILE A  60
ILE A 353
ILE A 197
 None
 0.99A 4q5mA-2vhlA:
undetectable		 4q5mA-2vhlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 ALA A 178
HIS A  63
GLU A 251
HIS A 223
GLU A 136
 None
FE  A1397 (-3.3A)
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.6A)
 1.08A 4r7lA-2vhlA:
undetectable		 4r7lA-2vhlA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 THR A 176
THR A 250
VAL A 249
ILE A  62
HIS A 134
 None
 1.31A 4s0vA-2vhlA:
undetectable		 4s0vA-2vhlA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 6 HIS A  63
HIS A  65
HIS A 202
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
FE  A1397 (-3.3A)
FE  A1398 ( 3.3A)
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 0.60A 4ubpC-2vhlA:
19.3		 4ubpC-2vhlA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 8 GLU A 251
HIS A 223
GLY A 201
HIS A  63
HIS A 202
 None
FE  A1398 (-3.3A)
None
FE  A1397 (-3.3A)
FE  A1398 ( 3.3A)
 1.46A 5f8yA-2vhlA:
undetectable		 5f8yA-2vhlA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		3 / 3 ALA A 110
GLN A 102
THR A  99
 None
 0.68A 5n0oA-2vhlA:
undetectable		 5n0oA-2vhlA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 SER A  94
LEU A 131
ILE A  60
ALA A 366
GLY A 363
 None
 1.04A 5veuB-2vhlA:
undetectable		 5veuB-2vhlA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 6 ILE A 107
ILE A 188
LEU A 191
PHE A 161
PHE A 248
 None
 1.49A 5vkqB-2vhlA:
undetectable
5vkqC-2vhlA:
undetectable		 5vkqB-2vhlA:
12.48
5vkqC-2vhlA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 6 ILE A 107
ILE A 188
LEU A 191
PHE A 161
PHE A 248
 None
 1.47A 5vkqC-2vhlA:
undetectable
5vkqD-2vhlA:
undetectable		 5vkqC-2vhlA:
12.48
5vkqD-2vhlA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 5 LEU A  87
THR A  92
THR A 380
GLY A  91
 None
 1.19A 6gtqA-2vhlA:
undetectable		 6gtqA-2vhlA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		4 / 7 SER A  76
ALA A  70
ILE A  64
ALA A  97
 None
 0.82A 6ma7A-2vhlA:
undetectable		 6ma7A-2vhlA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 HIS A  65
ASP A  71
ILE A 100
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
None
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 1.23A 6n91A-2vhlA:
14.8		 6n91A-2vhlA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 2vhl N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE
(Bacillus
subtilis) 		5 / 12 HIS A  65
ASP A  71
ILE A 100
HIS A 223
ASP A 281
 FE  A1397 (-3.3A)
None
None
FE  A1398 (-3.3A)
FE  A1397 ( 2.7A)
 1.23A 6n91B-2vhlA:
14.2		 6n91B-2vhlA:
13.44