SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vhq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.08A 1dfoA-2vhqA:
undetectable		 1dfoA-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.09A 1dfoB-2vhqA:
undetectable		 1dfoB-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.08A 1dfoC-2vhqA:
undetectable		 1dfoC-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.09A 1dfoD-2vhqA:
undetectable		 1dfoD-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.08A 1eqbA-2vhqA:
undetectable		 1eqbA-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.08A 1eqbB-2vhqA:
undetectable		 1eqbB-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.08A 1eqbC-2vhqA:
undetectable		 1eqbC-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 GLY A 219
LEU A 214
VAL A 194
ALA A 222
SER A 232
 None
 1.09A 1eqbD-2vhqA:
undetectable		 1eqbD-2vhqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 11 PHE A  30
ALA A 114
LEU A 147
ALA A 146
VAL A 185
 None
 1.08A 2bxeB-2vhqA:
undetectable		 2bxeB-2vhqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 LEU A  99
VAL A  46
SER A 208
PHE A 169
ASN A 170
 None
 1.41A 2y00B-2vhqA:
undetectable		 2y00B-2vhqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 LEU A  99
VAL A  46
SER A 208
PHE A 169
ASN A 170
 None
 1.41A 2y01B-2vhqA:
undetectable		 2y01B-2vhqA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		4 / 8 MET A 221
ALA A 222
GLY A 219
ILE A 218
 None
 0.58A 2zm9A-2vhqA:
undetectable		 2zm9A-2vhqA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 12 ASN A 166
PHE A 158
SER A 190
ILE A 176
LEU A 214
 None
 1.18A 3iv6A-2vhqA:
undetectable		 3iv6A-2vhqA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		4 / 6 ALA A  48
ASP A 217
LEU A  99
SER A  82
 None
 0.99A 4ot2A-2vhqA:
undetectable		 4ot2A-2vhqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 10 ASP A 213
GLY A  97
SER A 216
GLY A 219
MET A 125
 None
 1.25A 4xpbA-2vhqA:
undetectable		 4xpbA-2vhqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		4 / 5 ALA A 154
TYR A 153
GLY A 132
LEU A 294
 None
 1.01A 5eslA-2vhqA:
undetectable		 5eslA-2vhqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2vhq NTPASE P4
(Pseudomonas
phage
phi12) 		5 / 11 ASP A 189
VAL A 128
VAL A 126
MET A 125
LEU A 191
 MG  A1328 ( 4.5A)
None
None
None
None
 1.25A 5jkwA-2vhqA:
undetectable		 5jkwA-2vhqA:
21.14