SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vhs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 2vhs CATHSILICATEIN
(Homo
sapiens) 		6 / 10 GLN A  19
GLY A  23
PHE A  28
SER A  29
HIS A 163
ALA A 164
 SO4  A1221 (-3.2A)
SO4  A1221 (-3.5A)
None
None
SO4  A1221 (-3.8A)
None
 0.34A 1stfE-2vhsA:
34.5
1stfI-2vhsA:
undetectable		 1stfE-2vhsA:
38.74
1stfI-2vhsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		5 / 10 SER A  57
ALA A  73
ASN A  62
ALA A  27
TYR A  76
 None
 1.46A 2r2vC-2vhsA:
undetectable
2r2vF-2vhsA:
undetectable
2r2vG-2vhsA:
undetectable		 2r2vC-2vhsA:
10.91
2r2vF-2vhsA:
10.91
2r2vG-2vhsA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 163
TRP A 189
 SO4  A1221 (-3.2A)
SO4  A1221 (-3.5A)
SO4  A1221 (-3.8A)
None
 0.38A 3ai8A-2vhsA:
28.2		 3ai8A-2vhsA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 8 ASP A 109
LEU A  53
LEU A  34
SER A 105
 None
 0.88A 3lm8A-2vhsA:
undetectable
3lm8C-2vhsA:
undetectable		 3lm8A-2vhsA:
18.30
3lm8C-2vhsA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		3 / 3 LEU A  69
ASP A  71
TYR A  72
 None
 0.63A 4qc6B-2vhsA:
undetectable		 4qc6B-2vhsA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 4 LYS A  17
ASP A  55
GLU A  86
THR A  31
 None
 1.37A 5d4uA-2vhsA:
0.0		 5d4uA-2vhsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 4 LYS A  17
ASP A  55
GLU A  86
THR A  31
 None
 1.39A 5d4uB-2vhsA:
0.0		 5d4uB-2vhsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 4 LYS A  17
ASP A  55
GLU A  86
THR A  31
 None
 1.37A 5d4uC-2vhsA:
undetectable		 5d4uC-2vhsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 4 LYS A  17
ASP A  55
GLU A  86
THR A  31
 None
 1.36A 5d4uD-2vhsA:
undetectable		 5d4uD-2vhsA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2vhs CATHSILICATEIN
(Homo
sapiens) 		4 / 7 LEU A 144
ASN A 187
VAL A 199
GLU A 192
 None
 1.12A 5tudA-2vhsA:
undetectable		 5tudA-2vhsA:
17.90