SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vif'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens) 		5 / 11 LEU A 420
ILE A 433
HIS A 451
PHE A 442
ASP A 464
 None
 1.14A 1zz1A-2vifA:
undetectable		 1zz1A-2vifA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens) 		4 / 7 LEU A 457
LEU A 398
VAL A 408
LEU A 487
 None
 0.94A 3g8iA-2vifA:
undetectable		 3g8iA-2vifA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens) 		3 / 3 GLU A 395
ARG A 391
HIS A 430
 None
 0.85A 4kf9A-2vifA:
undetectable		 4kf9A-2vifA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens) 		3 / 3 ARG A 415
ASP A 413
TYR A 443
 None
 0.90A 4yo9B-2vifA:
undetectable		 4yo9B-2vifA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 2vif SUPPRESSOR OF
CYTOKINE SIGNALLING
6
(Homo
sapiens) 		3 / 3 ARG A 432
HIS A 430
ARG A 409
 None
 1.06A 6dwdD-2vifA:
undetectable		 6dwdD-2vifA:
14.23