SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vj5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		3 / 3 PHE A 188
TRP A 202
GLU A 201
 None
 1.19A 1mogA-2vj5A:
undetectable		 1mogA-2vj5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 7 TYR A 114
ILE A  90
ASP A  92
PHE A  91
 None
 0.93A 1upfB-2vj5A:
undetectable		 1upfB-2vj5A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 5 SER A 306
HIS A 307
LEU A 273
SER A 272
 None
 1.24A 2qhfA-2vj5A:
0.0		 2qhfA-2vj5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 12 LEU A 273
HIS A 307
LEU A 267
SER A 306
ALA A 305
 None
 1.22A 2vmyB-2vj5A:
undetectable		 2vmyB-2vj5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		3 / 3 GLU A 335
HIS A 325
GLU A 331
 None
 0.60A 2x45B-2vj5A:
undetectable		 2x45B-2vj5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		3 / 3 GLU A 335
HIS A 325
GLU A 331
 None
 0.61A 2x45C-2vj5A:
undetectable		 2x45C-2vj5A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 7 GLN A 220
ILE A 214
SER A 221
CYH A 184
 None
 1.37A 2xz5D-2vj5A:
undetectable
2xz5E-2vj5A:
undetectable		 2xz5D-2vj5A:
22.58
2xz5E-2vj5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 7 GLN A 220
ILE A 214
TYR A 185
CYH A 184
 None
 1.36A 2xz5D-2vj5A:
undetectable
2xz5E-2vj5A:
undetectable		 2xz5D-2vj5A:
22.58
2xz5E-2vj5A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 8 LYS A 155
ARG A 126
ASP A 225
GLU A 237
 None
 1.39A 3dh0A-2vj5A:
undetectable		 3dh0A-2vj5A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FGR_B_ACTB21_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2 40 KDA FORM)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 4 ARG A 186
ASP A  80
ASP A 117
PRO A 118
 None
 1.11A 3fgrB-2vj5A:
undetectable		 3fgrB-2vj5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		3 / 3 ILE A 150
VAL A 122
ARG A 126
 None
 0.73A 3p73A-2vj5A:
undetectable		 3p73A-2vj5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 12 SER A 319
VAL A 320
GLN A 287
ILE A 285
PHE A 328
 None
 1.45A 4c49B-2vj5A:
undetectable		 4c49B-2vj5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 7 VAL A 215
ILE A 248
LEU A 282
LEU A 283
 None
 1.00A 4xo7A-2vj5A:
undetectable		 4xo7A-2vj5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 5 SER A 306
ALA A 305
HIS A 307
LEU A 273
 None
 1.50A 5dzkf-2vj5A:
undetectable
5dzkt-2vj5A:
undetectable		 5dzkf-2vj5A:
22.26
5dzkt-2vj5A:
0.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 12 LYS A 155
VAL A 157
ASN A 158
ILE A 161
VAL A 122
 None
 0.82A 5j2tC-2vj5A:
undetectable		 5j2tC-2vj5A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 10 ILE A 149
ILE A 145
LEU A 142
ILE A 161
ASN A 158
 None
 1.39A 5vkqA-2vj5A:
3.8
5vkqD-2vj5A:
4.1		 5vkqA-2vj5A:
10.41
5vkqD-2vj5A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 10 ILE A 161
ASN A 158
ILE A 149
ILE A 145
LEU A 142
 None
 1.39A 5vkqA-2vj5A:
3.8
5vkqB-2vj5A:
3.2		 5vkqA-2vj5A:
10.41
5vkqB-2vj5A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		5 / 10 ILE A 161
ASN A 158
ILE A 149
ILE A 145
LEU A 142
 None
 1.39A 5vkqC-2vj5A:
4.1
5vkqD-2vj5A:
4.1		 5vkqC-2vj5A:
10.41
5vkqD-2vj5A:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 2vj5 PROTEIN MXIC
(Shigella
flexneri) 		4 / 8 GLN A 121
ILE A 145
GLN A 138
ASP A 104
 None
 1.05A 5vlmD-2vj5A:
3.6		 5vlmD-2vj5A:
20.63