SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vjt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 6 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 1.02A 1ictB-2vjtB:
undetectable		 1ictB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 2vjt ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		5 / 10 TYR B  12
LEU B  24
ALA B  22
VAL B   8
ALA B   7
 None
 0.95A 1xp0A-2vjtB:
undetectable		 1xp0A-2vjtB:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2vjt ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		5 / 11 ILE B  52
ALA B  55
ALA B  56
LEU B  60
ALA B 132
 None
None
None
CYC  B1081 (-4.7A)
None
 1.11A 2aclE-2vjtB:
3.2		 2aclE-2vjtB:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2vjt ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		3 / 3 LEU B 112
TYR B 116
GLY B 120
 None
None
MEN  B  71 ( 4.2A)
 0.63A 2ocuA-2vjtB:
undetectable		 2ocuA-2vjtB:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
(Gloeobacter
violaceus) 		4 / 5 ILE A  39
ARG A  36
ARG A  35
ASP A 145
 None
 1.22A 2rhmB-2vjtA:
undetectable		 2rhmB-2vjtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
(Gloeobacter
violaceus) 		3 / 3 ASP A 100
THR A 138
GLU A 148
 None
 0.75A 2zifB-2vjtA:
undetectable		 2zifB-2vjtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2vjt ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 8 LEU B  89
PHE B 153
VAL B 136
ALA B 149
 None
 1.00A 3ax9A-2vjtB:
undetectable		 3ax9A-2vjtB:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 6 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 0.99A 3cfqA-2vjtB:
undetectable		 3cfqA-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 7 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 0.99A 3cfqA-2vjtB:
undetectable
3cfqB-2vjtB:
undetectable		 3cfqA-2vjtB:
22.78
3cfqB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
(Gloeobacter
violaceus) 		3 / 3 TYR A  88
TYR A 155
GLY A 108
 CYC  A1081 (-4.1A)
None
CYC  A1081 ( 4.0A)
 0.73A 3eteB-2vjtA:
undetectable
3eteD-2vjtA:
undetectable
3eteF-2vjtA:
undetectable		 3eteB-2vjtA:
14.62
3eteD-2vjtA:
14.62
3eteF-2vjtA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 6 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 0.99A 4ikiB-2vjtB:
undetectable		 4ikiB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 8 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 0.98A 4ikkA-2vjtB:
undetectable
4ikkB-2vjtB:
undetectable		 4ikkA-2vjtB:
22.78
4ikkB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		4 / 7 LEU B  97
ALA A   7
LEU A   4
SER A   2
 None
 1.04A 4ikkA-2vjtB:
undetectable
4ikkB-2vjtB:
undetectable		 4ikkA-2vjtB:
22.78
4ikkB-2vjtB:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vjt ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus) 		5 / 11 GLY B 138
ALA B  55
MET B  85
LEU B  89
MET B  96
 None
None
CYC  B1081 ( 4.0A)
None
None
 1.14A 4xumB-2vjtB:
undetectable		 4xumB-2vjtB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZXI_A_GLYA1402_0
(TYROCIDINE
SYNTHETASE 3)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		4 / 7 ASP B   3
ILE B   5
GLY A  99
THR A   5
 None
 0.90A 4zxiA-2vjtB:
undetectable		 4zxiA-2vjtB:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		5 / 10 ALA B  35
VAL A  30
PHE B  31
ILE B   5
ALA B   4
 None
 1.49A 6h1lA-2vjtB:
undetectable		 6h1lA-2vjtB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT
(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		4 / 6 TYR B  94
ILE A   8
ALA A  13
ASP B  86
 None
 1.16A 6hu9m-2vjtB:
undetectable
6hu9q-2vjtB:
undetectable		 6hu9m-2vjtB:
14.79
6hu9q-2vjtB:
20.61