SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 9 ALA A 252
GLU A  20
LEU A  89
ARG A  17
ILE A  62
 None
None
None
GZL  A1298 (-3.9A)
None
 1.48A 1ereA-2vk2A:
undetectable		 1ereA-2vk2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 9 ALA A 252
GLU A  20
LEU A  89
ARG A  17
ILE A  62
 None
None
None
GZL  A1298 (-3.9A)
None
 1.48A 1ereB-2vk2A:
undetectable		 1ereB-2vk2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 9 ALA A 252
GLU A  20
LEU A  89
ARG A  17
ILE A  62
 None
None
None
GZL  A1298 (-3.9A)
None
 1.49A 1ereC-2vk2A:
undetectable		 1ereC-2vk2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 8 LEU A 134
ARG A 146
PHE A 150
GLY A 113
 None
GZL  A1298 (-2.7A)
None
None
 0.89A 1fapB-2vk2A:
undetectable		 1fapB-2vk2A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 8 LEU A 279
GLY A 228
TRP A 119
LEU A 281
 None
 0.83A 1jlbA-2vk2A:
2.0		 1jlbA-2vk2A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 10 ALA A 252
GLU A  20
LEU A  89
ARG A  17
ILE A  62
 None
None
None
GZL  A1298 (-3.9A)
None
 1.44A 1qkuB-2vk2A:
undetectable		 1qkuB-2vk2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		3 / 3 ARG A 146
VAL A 229
TRP A  16
 GZL  A1298 (-2.7A)
None
None
 1.09A 1qw6A-2vk2A:
undetectable		 1qw6A-2vk2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		3 / 3 ARG A 146
VAL A 229
TRP A  16
 GZL  A1298 (-2.7A)
None
None
 1.07A 1vagA-2vk2A:
undetectable		 1vagA-2vk2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		3 / 3 ARG A 146
VAL A 229
TRP A  16
 GZL  A1298 (-2.7A)
None
None
 1.05A 1zviA-2vk2A:
undetectable		 1zviA-2vk2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 8 ARG A  17
GLY A 136
THR A 137
ALA A 140
ALA A 143
 GZL  A1298 (-3.9A)
None
None
None
None
 1.14A 2ej3C-2vk2A:
undetectable		 2ej3C-2vk2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 6 LEU A  89
SER A  14
ASP A 201
GLU A  20
 None
GZL  A1298 (-2.7A)
None
None
 1.10A 2vn1B-2vk2A:
undetectable		 2vn1B-2vk2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 8 ILE A  62
GLY A   6
VAL A  75
GLN A  47
 None
 0.88A 4acbB-2vk2A:
5.5
4acbC-2vk2A:
4.6		 4acbB-2vk2A:
22.92
4acbC-2vk2A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 8 SER A 244
LEU A 134
SER A 225
THR A 223
 None
 0.73A 4ikjA-2vk2A:
undetectable
4ikjB-2vk2A:
undetectable		 4ikjA-2vk2A:
18.82
4ikjB-2vk2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 8 LEU A 134
SER A 225
THR A 223
SER A 244
 None
 0.79A 4ikkA-2vk2A:
undetectable
4ikkB-2vk2A:
undetectable		 4ikkA-2vk2A:
18.82
4ikkB-2vk2A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 9 ALA A 252
ALA A 255
LEU A  88
LEU A  35
VAL A   5
 None
 1.38A 4or0A-2vk2A:
undetectable		 4or0A-2vk2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 12 LEU A  35
PRO A  85
ILE A  84
PHE A  63
VAL A  23
 None
 1.24A 5dlvB-2vk2A:
1.0		 5dlvB-2vk2A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		5 / 12 VAL A  55
LEU A  88
LEU A  76
ALA A  79
THR A 103
 None
 1.20A 5nd3B-2vk2A:
2.5		 5nd3B-2vk2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UMD_A_YMZA3801_1
(60S RIBOSOMAL
PROTEIN L28
28S RIBOSOMAL RNA
60S RIBOSOMAL
PROTEIN L4)		 2vk2 ABC TRANSPORTER
PERIPLASMIC-BINDING
PROTEIN YTFQ
(Escherichia
coli) 		4 / 6 ASN A  22
ALA A  19
VAL A  23
TYR A 297
 None
 1.23A 5umd2-2vk2A:
undetectable
5umdF-2vk2A:
undetectable		 5umd2-2vk2A:
14.05
5umdF-2vk2A:
16.14