SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vk4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.40A 1c9sB-2vk4A:
undetectable
1c9sC-2vk4A:
undetectable
1c9sB-2vk4A:
8.71
1c9sC-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.92A 1dfoA-2vk4A:
1.9
1dfoA-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.93A 1dfoB-2vk4A:
1.7
1dfoB-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.92A 1dfoC-2vk4A:
undetectable
1dfoC-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.92A 1dfoD-2vk4A:
undetectable
1dfoD-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 PHE A 502
LEU A 535
VAL A 468
VAL A 451
None
1.08A 1e7aB-2vk4A:
undetectable
1e7aB-2vk4A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.94A 1eqbA-2vk4A:
undetectable
1eqbA-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.94A 1eqbB-2vk4A:
1.7
1eqbB-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.94A 1eqbC-2vk4A:
undetectable
1eqbC-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
0.94A 1eqbD-2vk4A:
1.6
1eqbD-2vk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 8 MET A 138
ALA A 145
LEU A   6
LEU A  10
None
0.86A 1ereE-2vk4A:
undetectable
1ereE-2vk4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 8 MET A 138
ALA A 145
LEU A   6
LEU A  10
None
0.85A 1ereF-2vk4A:
undetectable
1ereF-2vk4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 4 ILE A 201
LEU A 281
VAL A 307
ILE A 316
None
0.90A 1fm6D-2vk4A:
undetectable
1fm6D-2vk4A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_H_TRPH81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.40A 1gtfG-2vk4A:
undetectable
1gtfH-2vk4A:
undetectable
1gtfG-2vk4A:
8.71
1gtfH-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 THR A 390
SER A 391
LEU A 365
VAL A 512
VAL A 370
TPP  A 600 (-3.1A)
None
None
None
None
1.14A 1q23C-2vk4A:
undetectable
1q23C-2vk4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 THR A 390
SER A 391
LEU A 365
VAL A 512
VAL A 370
TPP  A 600 (-3.1A)
None
None
None
None
1.13A 1q23I-2vk4A:
undetectable
1q23I-2vk4A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 LEU A 281
ILE A 201
LEU A 333
VAL A 324
THR A 314
None
1.11A 1tw4A-2vk4A:
undetectable
1tw4A-2vk4A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 7 GLY A 250
PHE A 400
PRO A 401
ASP A 382
None
1.19A 2aouB-2vk4A:
2.5
2aouB-2vk4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 ASN A  83
GLY A 416
GLY A  87
VAL A  93
ASP A  59
None
1.47A 2fqyA-2vk4A:
4.4
2fqyA-2vk4A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 ALA A 392
GLY A 413
SER A 446
None
TPP  A 600 (-4.9A)
TPP  A 600 (-2.7A)
0.34A 2ivuA-2vk4A:
undetectable
2ivuA-2vk4A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 HIS A 495
ILE A 454
LEU A 440
None
0.54A 2kceA-2vk4A:
undetectable
2kceA-2vk4A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
1.00A 2vmyB-2vk4A:
undetectable
2vmyB-2vk4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A  82
GLY A  84
LEU A  79
ALA A  55
SER A 130
None
1.01A 2vmyA-2vk4A:
undetectable
2vmyA-2vk4A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 ASP A  59
ARG A  63
MET A 247
HIS A 225
GLY A  87
None
1.44A 2y6rC-2vk4A:
undetectable
2y6rC-2vk4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 7 ILE A 385
LEU A 440
MET A 457
THR A 456
None
0.95A 3ag2N-2vk4A:
undetectable
3ag2W-2vk4A:
undetectable
3ag2N-2vk4A:
22.83
3ag2W-2vk4A:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_B_HNQB255_1
(CATHEPSIN B)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 GLN A 160
GLY A  94
HIS A 225
CYH A 221
None
1.42A 3ai8B-2vk4A:
undetectable
3ai8B-2vk4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 TRP A  45
VAL A  95
ARG A 224
None
0.86A 3b0wA-2vk4A:
undetectable
3b0wA-2vk4A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 PRO A 191
LEU A 189
GLN A 325
None
0.61A 3hznG-2vk4A:
undetectable
3hznH-2vk4A:
0.2
3hznG-2vk4A:
18.15
3hznH-2vk4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 GLN A 397
THR A 398
LEU A 540
None
0.75A 3ondA-2vk4A:
undetectable
3ondA-2vk4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 GLN A 397
THR A 398
LEU A 540
None
0.75A 3ondB-2vk4A:
3.2
3ondB-2vk4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 GLN A 160
GLY A  66
ILE A  85
ALA A  58
ALA A  55
None
1.05A 3sueA-2vk4A:
undetectable
3sueA-2vk4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 GLN A 373
THR A 523
ASN A 519
None
0.71A 3v4tE-2vk4A:
undetectable
3v4tE-2vk4A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 4 PRO A 500
LEU A 499
ILE A 533
ARG A 534
None
1.47A 3w1wA-2vk4A:
2.2
3w1wA-2vk4A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 7 LYS A 436
VAL A 438
TYR A  61
LEU A 462
None
1.10A 4b3qA-2vk4A:
undetectable
4b3qA-2vk4A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A 296
ILE A 476
LEU A 540
GLY A 394
PHE A 393
None
TPP  A 600 (-3.6A)
None
None
None
1.28A 4fogA-2vk4A:
undetectable
4fogA-2vk4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 8 GLY A 420
LEU A 449
TYR A  56
ASN A  53
None
1.26A 4m5mA-2vk4A:
undetectable
4m5mA-2vk4A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 ARG A 224
GLY A  60
ALA A 421
VAL A 383
VAL A 438
None
1.10A 4nkvD-2vk4A:
undetectable
4nkvD-2vk4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 ASP A 236
GLU A 230
VAL A 285
ALA A 218
None
0.97A 4nkxA-2vk4A:
undetectable
4nkxA-2vk4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.12A 4qvpH-2vk4A:
undetectable
4qvpI-2vk4A:
undetectable
4qvpH-2vk4A:
18.75
4qvpI-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.12A 4qvpV-2vk4A:
undetectable
4qvpW-2vk4A:
undetectable
4qvpV-2vk4A:
18.75
4qvpW-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.14A 4qvvH-2vk4A:
undetectable
4qvvH-2vk4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.13A 4qvvV-2vk4A:
undetectable
4qvvV-2vk4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.13A 4qvyH-2vk4A:
undetectable
4qvyH-2vk4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.13A 4qvyV-2vk4A:
undetectable
4qvyW-2vk4A:
undetectable
4qvyV-2vk4A:
18.75
4qvyW-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.12A 4qw0H-2vk4A:
undetectable
4qw0I-2vk4A:
undetectable
4qw0H-2vk4A:
18.75
4qw0I-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.11A 4qw0V-2vk4A:
undetectable
4qw0W-2vk4A:
undetectable
4qw0V-2vk4A:
18.75
4qw0W-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
6 / 12 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
None
1.18A 4v01A-2vk4A:
undetectable
4v01A-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
6 / 12 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
None
1.19A 4v04A-2vk4A:
undetectable
4v04A-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
6 / 12 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
None
1.13A 4v04B-2vk4A:
undetectable
4v04B-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 TYR A 299
GLY A 286
SER A 284
LEU A 217
None
1.18A 5bphD-2vk4A:
undetectable
5bphD-2vk4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 SER A  88
GLN A 160
ALA A 421
GLY A  60
ALA A  58
None
1.14A 5cz7V-2vk4A:
undetectable
5cz7W-2vk4A:
undetectable
5cz7V-2vk4A:
18.75
5cz7W-2vk4A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.40A 5eeuD-2vk4A:
undetectable
5eeuE-2vk4A:
undetectable
5eeuD-2vk4A:
8.71
5eeuE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5eevD-2vk4A:
undetectable
5eevE-2vk4A:
undetectable
5eevD-2vk4A:
8.71
5eevE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.40A 5eewD-2vk4A:
undetectable
5eewE-2vk4A:
undetectable
5eewD-2vk4A:
8.71
5eewE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.36A 5eewH-2vk4A:
undetectable
5eewI-2vk4A:
undetectable
5eewH-2vk4A:
8.71
5eewI-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5eexD-2vk4A:
undetectable
5eexE-2vk4A:
undetectable
5eexD-2vk4A:
8.71
5eexE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_H_TRPH101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5eexH-2vk4A:
undetectable
5eexI-2vk4A:
undetectable
5eexH-2vk4A:
8.71
5eexI-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5eexI-2vk4A:
undetectable
5eexJ-2vk4A:
undetectable
5eexI-2vk4A:
8.71
5eexJ-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5eeyD-2vk4A:
undetectable
5eeyE-2vk4A:
undetectable
5eeyD-2vk4A:
8.71
5eeyE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5eeyI-2vk4A:
undetectable
5eeyJ-2vk4A:
undetectable
5eeyI-2vk4A:
8.71
5eeyJ-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5eezD-2vk4A:
undetectable
5eezE-2vk4A:
undetectable
5eezD-2vk4A:
8.71
5eezE-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5eezI-2vk4A:
undetectable
5eezJ-2vk4A:
undetectable
5eezI-2vk4A:
8.71
5eezJ-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5ef0D-2vk4A:
undetectable
5ef0E-2vk4A:
undetectable
5ef0D-2vk4A:
8.71
5ef0E-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5ef0I-2vk4A:
undetectable
5ef0J-2vk4A:
undetectable
5ef0I-2vk4A:
8.71
5ef0J-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5ef1D-2vk4A:
undetectable
5ef1E-2vk4A:
undetectable
5ef1D-2vk4A:
8.71
5ef1E-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5ef1I-2vk4A:
undetectable
5ef1J-2vk4A:
undetectable
5ef1I-2vk4A:
8.71
5ef1J-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5ef2D-2vk4A:
undetectable
5ef2E-2vk4A:
undetectable
5ef2D-2vk4A:
8.71
5ef2E-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5ef2I-2vk4A:
undetectable
5ef2J-2vk4A:
undetectable
5ef2I-2vk4A:
8.71
5ef2J-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_D_TRPD101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.41A 5ef3D-2vk4A:
undetectable
5ef3E-2vk4A:
undetectable
5ef3D-2vk4A:
8.71
5ef3E-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 11 ARG A 459
THR A  21
GLY A 424
ALA A  54
THR A 456
None
1.37A 5ef3I-2vk4A:
undetectable
5ef3J-2vk4A:
undetectable
5ef3I-2vk4A:
8.71
5ef3J-2vk4A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 ALA A 425
GLY A  84
GLY A 420
GLY A  94
VAL A  95
None
0.94A 5i73A-2vk4A:
undetectable
5i73A-2vk4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 ALA A 287
LEU A 289
TYR A 299
SER A 284
None
1.14A 5phhA-2vk4A:
undetectable
5phhA-2vk4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 GLY A 120
ASN A 119
ARG A 127
None
0.73A 5w7bD-2vk4A:
undetectable
5w7bD-2vk4A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 6 PHE A  11
ARG A  13
LEU A  14
GLN A  16
None
0.82A 6b89B-2vk4A:
undetectable
6b89B-2vk4A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 12 LEU A 549
ILE A 480
HIS A 481
THR A 556
LEU A 555
None
1.11A 6djzB-2vk4A:
undetectable
6djzB-2vk4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
5 / 10 VAL A  98
LEU A  33
LEU A  34
LEU A  14
LEU A  10
None
0.93A 6f5uA-2vk4A:
undetectable
6f5uB-2vk4A:
undetectable
6f5uA-2vk4A:
9.98
6f5uB-2vk4A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 ARG A 532
LYS A 463
TYR A 465
None
1.31A 6gnaA-2vk4A:
undetectable
6gnaA-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
3 / 3 ARG A 532
LYS A 463
TYR A 465
None
1.31A 6gnbA-2vk4A:
undetectable
6gnbA-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis)
4 / 7 GLY A 424
ASN A  53
GLU A  51
GLY A  24
None
0.97A 6n7fA-2vk4A:
3.1
6n7fA-2vk4A:
10.10