SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vk9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		6 / 12 ILE A 299
LEU A 293
VAL A 348
ALA A 317
ILE A 318
ILE A 357
 None
 1.31A 1epbB-2vk9A:
undetectable		 1epbB-2vk9A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 12 GLY A 107
SER A 137
LEU A 270
LEU A 257
TYR A 253
 None
 1.20A 1fm6D-2vk9A:
undetectable		 1fm6D-2vk9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 7 ASP A 268
LEU A 526
SER A 470
ASN A 469
 None
 1.21A 1ig3A-2vk9A:
undetectable
1ig3B-2vk9A:
undetectable		 1ig3A-2vk9A:
19.03
1ig3B-2vk9A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 8 SER A  78
ILE A  11
VAL A  56
SER A  66
 None
 1.06A 1kb9A-2vk9A:
undetectable
1kb9C-2vk9A:
2.2
1kb9D-2vk9A:
undetectable
1kb9E-2vk9A:
undetectable		 1kb9A-2vk9A:
22.39
1kb9C-2vk9A:
20.46
1kb9D-2vk9A:
18.15
1kb9E-2vk9A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T03_P_TFOP822_1
(POL POLYPROTEIN
SYNTHETIC
OLIGONUCLEOTIDE
PRIMER)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 7 ASP A 496
MET A 447
ASP A 448
HIS A 489
 None
 1.30A 1t03A-2vk9A:
undetectable		 1t03A-2vk9A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 11 LEU A 139
ASP A 202
GLY A 106
ILE A 205
VAL A 201
 None
 1.45A 1tmxA-2vk9A:
undetectable		 1tmxA-2vk9A:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 5 ASP A 202
THR A 142
LEU A 143
LEU A 139
 None
 1.14A 1u18B-2vk9A:
undetectable		 1u18B-2vk9A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 8 ILE A 340
ILE A 299
VAL A 336
ILE A 314
 None
 0.87A 3p4wC-2vk9A:
3.7		 3p4wC-2vk9A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 9 ASP A 284
GLY A 476
ILE A 479
ILE A 370
ILE A 389
 None
 0.89A 3s45A-2vk9A:
undetectable		 3s45A-2vk9A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		3 / 3 TYR A 133
LEU A 249
LYS A 250
 None
 0.70A 3sueD-2vk9A:
undetectable		 3sueD-2vk9A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 12 LEU A 295
ILE A 344
ILE A 314
ILE A 353
HIS A 351
 None
 1.03A 3uj7A-2vk9A:
undetectable		 3uj7A-2vk9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 8 SER A 461
ILE A 456
LEU A 412
ILE A 416
 None
 0.87A 4dtaB-2vk9A:
undetectable		 4dtaB-2vk9A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 12 GLY A 107
SER A 137
LEU A 270
LEU A 257
TYR A 253
 None
 1.22A 4emaA-2vk9A:
undetectable		 4emaA-2vk9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_B_VK3B202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 6 ASN A 136
TYR A 253
TYR A 254
LEU A 257
 None
 1.29A 4f8yA-2vk9A:
undetectable
4f8yB-2vk9A:
undetectable		 4f8yA-2vk9A:
14.56
4f8yB-2vk9A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 7 TYR A 253
TYR A 254
LEU A 257
ASN A 136
 None
 1.29A 4f8yC-2vk9A:
undetectable
4f8yD-2vk9A:
undetectable		 4f8yC-2vk9A:
14.56
4f8yD-2vk9A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 9 GLY A 458
VAL A 433
SER A 434
VAL A 437
LEU A 438
 None
 0.71A 4qd3A-2vk9A:
undetectable		 4qd3A-2vk9A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		3 / 3 ASP A 202
ASN A 207
PHE A 213
 None
 0.77A 5dsgB-2vk9A:
2.8		 5dsgB-2vk9A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 7 LEU A 412
LYS A 185
ILE A 181
MET A 178
 None
 1.11A 5ljcA-2vk9A:
undetectable		 5ljcA-2vk9A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		5 / 12 LEU A 263
LEU A 257
ALA A 266
TYR A 133
LEU A 285
 None
 1.10A 5ljeA-2vk9A:
undetectable		 5ljeA-2vk9A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 7 TYR A 459
ILE A 416
ILE A 456
ILE A 411
 None
 0.92A 5murB-2vk9A:
4.5		 5murB-2vk9A:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 2vk9 ALPHA-TOXIN
(Clostridium
novyi) 		4 / 6 VAL A 281
ILE A 363
LYS A  98
TYR A 127
 None
 1.42A 5q1sA-2vk9A:
undetectable		 5q1sA-2vk9A:
21.62