SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		4 / 5 GLN A 450
THR A 479
HIS A 483
HIS A 449
 None
 1.35A 3g1uC-2vkiA:
undetectable		 3g1uC-2vkiA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		3 / 3 LYS A 495
TYR A 486
ARG A 474
 SO4  A1550 ( 4.7A)
None
SO4  A1550 (-2.9A)
 1.23A 4gc9A-2vkiA:
undetectable		 4gc9A-2vkiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA502_0
(RNA POLYMERASE
3D-POL)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 537
LYS A 538
LYS A 534
 None
 1.28A 4k50A-2vkiA:
undetectable		 4k50A-2vkiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_E_ACTE502_0
(RNA POLYMERASE
3D-POL)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 537
LYS A 538
LYS A 534
 None
 1.21A 4k50E-2vkiA:
undetectable		 4k50E-2vkiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI506_0
(RNA POLYMERASE
3D-POL)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		3 / 3 ARG A 537
LYS A 538
LYS A 534
 None
 1.23A 4k50I-2vkiA:
undetectable		 4k50I-2vkiA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 2vki 3-PHOPSHOINOSITIDE
DEPENDENT PROTEIN
KINASE 1
(Homo
sapiens) 		4 / 5 ARG A 537
HIS A 533
ALA A 532
PRO A 506
 None
 1.46A 5syiA-2vkiA:
undetectable		 5syiA-2vkiA:
12.07