SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.20A 1fk9A-2vkpA:
undetectable		 1fk9A-2vkpA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 11 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.11A 1fkpA-2vkpA:
undetectable		 1fkpA-2vkpA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.21A 1ikwA-2vkpA:
undetectable		 1ikwA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		4 / 8 LEU A  66
TYR A  91
GLY A  33
TYR A  70
 None
 1.01A 1jlfA-2vkpA:
undetectable
1jlfB-2vkpA:
undetectable		 1jlfA-2vkpA:
11.61
1jlfB-2vkpA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.15A 1lw0A-2vkpA:
undetectable		 1lw0A-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 9 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.17A 1lwfA-2vkpA:
undetectable		 1lwfA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 9 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.19A 1vrtA-2vkpA:
undetectable		 1vrtA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HND_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.22A 2hndA-2vkpA:
undetectable		 2hndA-2vkpA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.26A 2hnyA-2vkpA:
undetectable		 2hnyA-2vkpA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		3 / 3 LYS A  90
GLY A  15
PRO A  16
 None
 0.71A 2hreB-2vkpA:
undetectable		 2hreB-2vkpA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 9 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.27A 3lp0A-2vkpA:
undetectable		 3lp0A-2vkpA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.18A 3mecA-2vkpA:
undetectable		 3mecA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 12 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.18A 3medA-2vkpA:
undetectable
3medB-2vkpA:
undetectable		 3medA-2vkpA:
11.61
3medB-2vkpA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.26A 3qipA-2vkpA:
undetectable		 3qipA-2vkpA:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		4 / 5 THR A  20
GLY A  15
VAL A  57
PRO A  55
 None
 1.11A 4grkA-2vkpA:
undetectable		 4grkA-2vkpA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 11 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.23A 5hbmA-2vkpA:
undetectable		 5hbmA-2vkpA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.17A 6bsgA-2vkpA:
undetectable		 6bsgA-2vkpA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6
(Homo
sapiens) 		5 / 10 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.12A 6bsjA-2vkpA:
undetectable		 6bsjA-2vkpA:
25.27