SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 ALA A 547
LEU A 543
LEU A 321
ALA A 364
THR A 548
 None
 1.09A 1bzfA-2vktA:
undetectable		 1bzfA-2vktA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 ALA A 410
ILE A 375
THR A 378
PHE A 409
LEU A 379
 None
 1.22A 1eiiA-2vktA:
undetectable		 1eiiA-2vktA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QFI_B_DVAB8_0
(ACTINOMYCIN X2)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		3 / 3 THR A 348
THR A 346
PRO A 351
 None
 0.86A 1qfiB-2vktA:
undetectable		 1qfiB-2vktA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		3 / 3 ARG A 311
TYR A 307
LYS A 306
 None
 0.88A 1uujB-2vktA:
undetectable		 1uujB-2vktA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DR2_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 11 GLY A 401
GLY A 371
GLN A 403
GLN A 524
ILE A 512
 None
 1.42A 2dr2A-2vktA:
undetectable		 2dr2A-2vktA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		3 / 3 PRO A 370
GLY A 305
TYR A 314
 None
 0.69A 2vouB-2vktA:
undetectable		 2vouB-2vktA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		3 / 3 PRO A 370
GLY A 305
TYR A 314
 None
 0.69A 2vouC-2vktA:
undetectable		 2vouC-2vktA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		3 / 3 GLU A 510
ARG A 449
HIS A 480
 None
 0.78A 4kf9A-2vktA:
undetectable		 4kf9A-2vktA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 ASP A 365
LEU A 543
HIS A 330
LEU A 332
ILE A 301
 None
 1.09A 4x1fA-2vktA:
undetectable		 4x1fA-2vktA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 12 ASP A 365
LEU A 543
HIS A 330
LEU A 332
ILE A 301
 None
 1.09A 4x1gA-2vktA:
undetectable		 4x1gA-2vktA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2vkt CTP SYNTHASE 2
(Homo
sapiens) 		5 / 9 ILE A 337
ILE A 393
PHE A 395
VAL A 521
GLU A 408
 None
 1.48A 5igzA-2vktA:
undetectable		 5igzA-2vktA:
21.66