SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vl7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 4 GLY A  75
ASP A 146
GLY A  47
THR A  40
 None
None
None
PO4  A1541 ( 4.8A)
 0.81A 1hxbB-2vl7A:
undetectable		 1hxbB-2vl7A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 7 LEU A 388
LEU A 456
PRO A  35
ARG A 507
 None
None
PO4  A1541 (-4.4A)
None
 1.00A 2jn3A-2vl7A:
undetectable		 2jn3A-2vl7A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 6 ASP A 519
TYR A 516
PHE A 391
LEU A 376
 None
 1.16A 2w98A-2vl7A:
undetectable
2w98B-2vl7A:
3.4		 2w98A-2vl7A:
20.55
2w98B-2vl7A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 12 ALA A 315
ILE A 179
THR A  28
LEU A 333
PRO A 330
 None
 1.26A 3cl9A-2vl7A:
2.4		 3cl9A-2vl7A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDV_A_CL6A506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 9 LEU A 178
VAL A  43
LEU A 316
ILE A 181
THR A  28
 None
 1.14A 3mdvA-2vl7A:
undetectable		 3mdvA-2vl7A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 12 VAL A  43
LEU A  46
ILE A 341
VAL A 343
LEU A  31
 None
 1.11A 4o1zB-2vl7A:
undetectable		 4o1zB-2vl7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		3 / 3 GLU A 476
TYR A 295
GLU A 246
 None
 0.59A 4ryaA-2vl7A:
undetectable		 4ryaA-2vl7A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 11 LEU A 203
ALA A 206
GLU A 209
LEU A 261
LEU A 281
 None
 1.29A 4zn7B-2vl7A:
undetectable		 4zn7B-2vl7A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 6 ALA A 495
THR A 494
VAL A 497
HIS A 491
 None
 1.05A 5eckA-2vl7A:
2.8		 5eckA-2vl7A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 8 TRP A  11
GLU A 345
PRO A 509
GLY A  36
 None
None
None
PO4  A1541 (-4.0A)
 1.13A 5kf8A-2vl7A:
undetectable		 5kf8A-2vl7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 8 TRP A  11
GLU A 345
PRO A 509
GLY A  36
 None
None
None
PO4  A1541 (-4.0A)
 1.13A 5kgpA-2vl7A:
undetectable		 5kgpA-2vl7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 8 TRP A  11
GLU A 345
PRO A 509
GLY A  36
 None
None
None
PO4  A1541 (-4.0A)
 1.12A 5kgpB-2vl7A:
undetectable		 5kgpB-2vl7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		3 / 3 GLY A  26
THR A  28
ASN A 337
 None
 0.58A 5odiG-2vl7A:
2.2		 5odiG-2vl7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 10 MET A 396
PHE A 391
SER A 399
ILE A 371
LEU A 376
 None
 1.45A 5zjiA-2vl7A:
undetectable
5zjiJ-2vl7A:
undetectable		 5zjiA-2vl7A:
8.66
5zjiJ-2vl7A:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		4 / 6 GLU A 524
ARG A 521
ASP A 528
ASP A 487
 None
 1.23A 5zw4A-2vl7A:
2.2		 5zw4A-2vl7A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_1
(TUBULIN BETA CHAIN)		 2vl7 XPD
(Sulfurisphaera
tokodaii) 		5 / 12 ASP A 307
LEU A 324
ALA A 190
LEU A 333
LEU A 481
 None
 1.23A 6ew0F-2vl7A:
undetectable		 6ew0F-2vl7A:
10.39