SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 12 VAL A 473
ARG A 253
LEU A 254
ILE A 403
THR A 489
 None
 1.10A 1d1gB-2vl8A:
undetectable		 1d1gB-2vl8A:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 12 ILE A 107
GLY A 105
LEU A 272
LEU A 259
TYR A 255
 None
 1.06A 1fm6X-2vl8A:
undetectable		 1fm6X-2vl8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L2I_A_CCSA417_0
(ESTROGEN RECEPTOR)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		3 / 3 GLU A 372
LYS A 367
VAL A 368
 None
 0.95A 1l2iA-2vl8A:
undetectable		 1l2iA-2vl8A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 5 LEU A 272
VAL A 252
TYR A 255
ARG A 241
 None
 1.28A 1nw3A-2vl8A:
undetectable		 1nw3A-2vl8A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 LEU A  79
GLU A  82
TYR A  34
ILE A  52
 None
 1.03A 1qvtA-2vl8A:
undetectable		 1qvtA-2vl8A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 VAL A  83
THR A  80
LEU A 481
PHE A 484
 None
 1.10A 1s8fB-2vl8A:
undetectable		 1s8fB-2vl8A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 5 ASP A 203
THR A 140
LEU A 141
LEU A 137
 None
 1.11A 1u18B-2vl8A:
undetectable		 1u18B-2vl8A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		3 / 3 GLN A 117
LYS A 119
VAL A 121
 None
 0.77A 2jfaB-2vl8A:
undetectable		 2jfaB-2vl8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 SER A  66
TYR A  59
THR A  56
LEU A  31
 None
 0.97A 2v0zO-2vl8A:
undetectable		 2v0zO-2vl8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 LEU A 221
ASN A 222
GLU A 226
LEU A 229
 None
 0.46A 2w8yA-2vl8A:
undetectable		 2w8yA-2vl8A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 PHE A 431
MET A 428
TYR A 407
ASN A 452
 None
 1.07A 2wekA-2vl8A:
undetectable		 2wekA-2vl8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 PHE A 431
MET A 428
TYR A 407
ASN A 452
 None
 1.07A 2wekB-2vl8A:
undetectable		 2wekB-2vl8A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 ARG A 499
LEU A 511
ASP A 288
GLU A 502
 None
None
CA  A1545 ( 2.8A)
None
 1.08A 2zw9A-2vl8A:
undetectable		 2zw9A-2vl8A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 ASP A  57
THR A  56
TYR A  59
HIS A  35
 None
 1.37A 3abkA-2vl8A:
2.2
3abkC-2vl8A:
4.9		 3abkA-2vl8A:
21.04
3abkC-2vl8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 ASP A  57
THR A  56
TYR A  59
HIS A  35
 None
 1.37A 3abkN-2vl8A:
undetectable
3abkP-2vl8A:
2.0		 3abkN-2vl8A:
21.04
3abkP-2vl8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 ASP A  57
THR A  56
TYR A  59
HIS A  35
 None
 1.37A 3ag3A-2vl8A:
2.1
3ag3C-2vl8A:
undetectable		 3ag3A-2vl8A:
21.04
3ag3C-2vl8A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_C_SRYC403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 12 ASN A  61
ASP A  57
ASN A  53
SER A 488
ASP A 442
 None
 1.36A 3havC-2vl8A:
0.6		 3havC-2vl8A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 LEU A   9
ALA A  26
LEU A  55
THR A  56
 None
 1.01A 3rozA-2vl8A:
undetectable		 3rozA-2vl8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 ASN A 415
GLU A 261
GLU A 258
TYR A 453
 None
 1.10A 3rqwC-2vl8A:
5.5
3rqwD-2vl8A:
5.5		 3rqwC-2vl8A:
20.07
3rqwD-2vl8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 8 GLU A 261
GLU A 258
TYR A 453
ASN A 415
 None
 1.10A 3rqwF-2vl8A:
undetectable
3rqwJ-2vl8A:
undetectable		 3rqwF-2vl8A:
20.07
3rqwJ-2vl8A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 PHE A 503
GLY A 292
PRO A 291
LEU A 363
 None
 0.95A 4dubB-2vl8A:
undetectable		 4dubB-2vl8A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 TYR A 284
LEU A 277
ASN A 384
TYR A 478
 None
None
CTS  A1544 (-3.9A)
None
 1.37A 4f8yC-2vl8A:
undetectable
4f8yD-2vl8A:
undetectable		 4f8yC-2vl8A:
14.63
4f8yD-2vl8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		3 / 3 ASP A 109
ASN A 116
SER A 228
 None
 0.85A 4obwA-2vl8A:
undetectable		 4obwA-2vl8A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 4 ILE A 375
ASN A 384
ILE A 274
VAL A 399
 None
CTS  A1544 (-3.9A)
None
None
 1.11A 4uy87-2vl8A:
undetectable		 4uy87-2vl8A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.21A 4yv5A-2vl8A:
1.9		 4yv5A-2vl8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 7 ASN A 467
TYR A 474
TYR A 478
LEU A 493
 None
 1.24A 4yv5B-2vl8A:
undetectable		 4yv5B-2vl8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 LYS A 119
ASP A 124
PRO A 291
LEU A 285
 None
 1.35A 5bmvB-2vl8A:
undetectable		 5bmvB-2vl8A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 TYR A 330
GLY A 292
SER A 509
LEU A 290
 None
 1.27A 5bphA-2vl8A:
undetectable		 5bphA-2vl8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_C_ACTC403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 4 TYR A 330
GLY A 292
SER A 509
LEU A 290
 None
 1.20A 5bphC-2vl8A:
undetectable		 5bphC-2vl8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_D_ACTD403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		4 / 6 TYR A 330
GLY A 292
SER A 509
LEU A 290
 None
 1.22A 5bphD-2vl8A:
undetectable		 5bphD-2vl8A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
CTS  A1544 ( 3.7A)
None
 1.20A 5kr2A-2vl8A:
undetectable		 5kr2A-2vl8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 9 ASN A 264
ALA A 267
ILE A 403
GLY A 470
ILE A 466
 None
None
None
CTS  A1544 ( 3.7A)
None
 0.97A 5kr2C-2vl8A:
undetectable		 5kr2C-2vl8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		5 / 12 ILE A  52
LEU A  28
LEU A  49
PHE A  75
LEU A  86
 None
 1.17A 6b54A-2vl8A:
undetectable		 6b54A-2vl8A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		3 / 3 TYR A  24
ALA A  71
LEU A   9
 None
 0.50A 6d9kF-2vl8A:
undetectable		 6d9kF-2vl8A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 2vl8 CYTOTOXIN L
(Paeniclostridium
sordellii) 		3 / 3 LYS A 278
SER A 389
SER A 393
 None
 1.13A 6gbfA-2vl8A:
undetectable		 6gbfA-2vl8A:
21.44