SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		4 / 6 TRP A 273
TYR A 258
TYR A 276
GLN A 275
 None
 1.36A 2pgzD-2vlaA:
undetectable
2pgzE-2vlaA:
undetectable		 2pgzD-2vlaA:
21.48
2pgzE-2vlaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		4 / 8 LEU A 232
LEU A 214
PRO A 177
VAL A 164
 None
 0.98A 2po5A-2vlaA:
undetectable		 2po5A-2vlaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RGU_B_356B902_1
(DIPEPTIDYL PEPTIDASE
4)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 11 GLU A 179
SER A 167
TYR A 163
VAL A 164
VAL A 170
 None
 1.39A 2rguB-2vlaA:
undetectable		 2rguB-2vlaA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		4 / 8 ASN A 166
SER A 167
MET A 207
VAL A 196
 None
 1.23A 2wekB-2vlaA:
undetectable		 2wekB-2vlaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		4 / 8 SER A 167
GLN A 137
GLN A 172
ILE A 133
 None
 1.17A 2xz5B-2vlaA:
undetectable
2xz5E-2vlaA:
undetectable		 2xz5B-2vlaA:
19.93
2xz5E-2vlaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		4 / 6 ASN A 117
TYR A 277
TYR A 216
ILE A  14
 None
 1.20A 3q5sA-2vlaA:
undetectable		 3q5sA-2vlaA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 12 SER A 156
VAL A 230
PHE A 138
ILE A 141
HIS A 209
 None
 1.44A 4c49D-2vlaA:
undetectable		 4c49D-2vlaA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 12 TYR A 140
GLN A 213
VAL A 164
ILE A 160
LEU A 145
 None
 1.37A 4k38A-2vlaA:
undetectable
4k38D-2vlaA:
undetectable		 4k38A-2vlaA:
20.48
4k38D-2vlaA:
5.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 12 TYR A 140
GLN A 213
VAL A 164
ILE A 160
LEU A 145
 None
 1.35A 4k38B-2vlaA:
undetectable		 4k38B-2vlaA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 9 VAL A 164
LEU A 146
LEU A 214
LEU A 232
ILE A 223
 None
 1.21A 4ubsA-2vlaA:
undetectable		 4ubsA-2vlaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 2vla RESTRICTION
ENDONUCLEASE R.BPUJI
(Bacillus
pumilus) 		5 / 10 PHE A 115
TYR A 258
PHE A 269
PHE A 260
VAL A 125
 None
 1.46A 6hu9C-2vlaA:
undetectable		 6hu9C-2vlaA:
19.29