SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vld'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 2vld UPF0286 PROTEIN
PYRAB01260
(Pyrococcus
abyssi) 		4 / 6 LEU A 207
ALA A 216
SER A 211
THR A 213
 None
 1.22A 4d7bB-2vldA:
undetectable		 4d7bB-2vldA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 2vld UPF0286 PROTEIN
PYRAB01260
(Pyrococcus
abyssi) 		4 / 4 ILE A 134
VAL A 172
VAL A 161
ARG A 150
 None
 1.29A 4m6tA-2vldA:
undetectable		 4m6tA-2vldA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2vld UPF0286 PROTEIN
PYRAB01260
(Pyrococcus
abyssi) 		4 / 9 ALA A 184
LEU A 220
LEU A 225
ILE A 206
 None
 0.84A 4xtaA-2vldA:
undetectable		 4xtaA-2vldA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2vld UPF0286 PROTEIN
PYRAB01260
(Pyrococcus
abyssi) 		4 / 6 LEU A 207
ALA A 216
SER A 211
THR A 213
 None
 1.18A 5l4iB-2vldA:
undetectable		 5l4iB-2vldA:
16.87