SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2vli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 HIS A 107
ILE A 165
LEU A  29
 None
 0.50A 2kceA-2vliA:
undetectable		 2kceA-2vliA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ILE A  81
ILE A 165
ALA A 162
PRO A  79
LEU A 171
 None
 1.22A 3a51E-2vliA:
undetectable		 3a51E-2vliA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 12 VAL A  34
SER A  32
ILE A  10
ILE A   8
LEU A 171
 None
 0.98A 3w67D-2vliA:
undetectable		 3w67D-2vliA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		5 / 12 ILE A   8
ALA A 162
ILE A 151
PHE A 109
THR A  21
 None
 1.28A 4cd2A-2vliA:
undetectable		 4cd2A-2vliA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 ILE A  86
MET A  96
ARG A  93
 None
 0.88A 4lnwA-2vliA:
undetectable		 4lnwA-2vliA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 2vli ANTIBIOTIC
RESISTANCE PROTEIN
(Deinococcus
radiodurans) 		3 / 3 ILE A  86
MET A  96
ARG A  93
 None
 0.89A 4lnxA-2vliA:
undetectable		 4lnxA-2vliA:
21.72